Browsing Library by Author "MacDonnell, Frederick M."
Now showing items 1-20 of 24
-
Assemblies Of Assemblies: Supramolecular Ordering Of Nanoscopic Ruthenium Polypyridyl Building Blocks
Wouters, Kelly Lyle (Chemistry & Biochemistry, 2008-04-22)Biological systems have long since perfected the development of nanoengineering. Cellular structure and machinery is based, to a significant extent, on the formation of nanometer to micron-sized assemblies of proteins. ... -
Catalytic Hydro-liquefaction Of Lignite Coals Under Mild Conditions
Alrashdan, Mahir (Chemistry & Biochemistry, 12-4-2012)A low-cost thermo-chemical process for the liquefaction of lignite coals is being developed at the University of Texas at Arlington (UTA). The coal-toliquids (CTL) project has focused of developing a liquefaction process ... -
CELL-FREE STUDIES OF CATALYTIC DNA CLEAVAGE BY RUTHENIUM POLYPYRIDYL COMPLEXES (RPCS) CONTAINING REDOX-ACTIVE INTERCALATING LIGANDS, ENANTIOMERIC SEPARATION AND SEMI-PREP SCALE PURIFICATION OF RPCS
Griffith, Cynthia Ann; 0000-0002-3851-0810 (2018-08-28)Herein, we report the ruthenium (II) polypyridyl complexes (RPCs), [(phen)₂Ru(tatpp)] ²⁺ (3²⁺) and [(phen)₂Ru(tatpp)Ru(phen)₂] ⁴⁺ (4⁴⁺) are shown to cleave DNA in cell-free studies in the presence of a mild reducing agent, ... -
Coupling Photodriven Multielectron Reduction Of Ruthenium Polypyridyl Complexes With Hydrogen Evolving Co-catalysts
McAlister, Cale (Chemistry & Biochemistry, 2007-09-17)With energy demands continuing to increase, the importance of finding a means of converting solar energy into a usable form of chemical energy continues to escalate. Photocatalysis provides a viable approach to harnessing ... -
Cytotoxicty, Cellular Localization And Fluorescent Microscopy Of Malignant Cells Treated With Ruthenium (II) Complexes Of The Tetraazatetrapyridopentacene Ligand
Dayoub, Adam S.The ruthenium (II) polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]4+, (P) and [(phen)2Ru(tatpp)]2+, (MP) are promising anticancer activity candidates due to their observed cytotoxic effect against multiple cancer cell ... -
Design And Synthesis Of A High Potential Ruthenium (II) Tetraazatetrapyridopentaphene Complex Capable Of Two-electron Reduction
Diaz, Nancy Ruth G. (Chemistry & Biochemistry, 2010-03-03)We report the synthesis of a complex, [(phen)₂Ru(tatpph)Ru(phen)₂]⁴⁺ (Ph⁴⁺), which like its predecessor compound, [(phen)₂Ru(tatppc)Ru(phen)₂]⁴⁺ (Pc ⁴⁺), can undergo two sequential 1-electron photoreductions in MeCN in ... -
Effect Of Structure And Stereochemistry On Cytotoxicity Of Ruthenium Polypyridyl Complexes
Krishnan, Arthi (Chemistry & Biochemistry, 2007-08-23)Efforts to develop novel non-platinum, metal-based antitumor drugs have been pursued by many groups and ruthenium complexes have drawn a lot of attention as prospective transition metal-based antineoplastic agents. Recently, ... -
ENANTIOSELECTIVE SYNTHESIS OF AN ANTICANCER RUTHENIUM POLYPYRIDYL COMPLEX (RPC) AND INFLUENCE OF CHIRAL SELECTIVITY ON DNA PHOTOCLEAVAGE
Ferdous, Shomita (2017-12-08)Ruthenium polypyridyl complexes (RPCs) represent a promising therapeiutic class of drugs for transition-metal based anticancer drug development. The complex [(phen)2Ru(tatpp)Ru(phen)2] (44+) is a RPC which has shown success ... -
Examining Ruthenium Chromophores For The Photochemical Reduction Of CO₂To Methanol
Boston, David J. (Chemistry & Biochemistry, 2014-03-12)Our consumption of energy for transportation and electricity has been growing as quickly as our population. As this demand for energy increases we increase our production of carbon dioxide by the burning of fossil fuels ... -
Increasing Lipophilicity Of Redox Active Ruthenium Complexes As A Means To Enhance Cytotoxicity And Reduce Animal Toxicity
Alatrash, Nagham (Chemistry & Biochemistry, 2013-03-20)The dinuclear and monomeric ruthenium(II) polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]Cl4 (P) and monomer [(phen)2Ru(tatpp)]Cl2 (MP) are promising candidates for anticancer drug development in terms of the observed ... -
INTRACELLULAR BIOCHEMICAL TARGETS OF RUTHENIUM POLYPYRIDYL COMPLEXES IN MULTIPLE CANCER CELL MODELS
Dayoub, Adam S. (2016-12-16)The ruthenium (II) polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]4+, RPC4 and [(phen)2Ru(tatpp)]2+, RPC3 are promising anticancer candidates due to their observed cytotoxic effect against multiple cancer cell lines. ... -
Investigation Of Redox-active Ruthenium(II) Polypyridyl Complexes As Potential Anti-cancer Drugs
Yadav, Abhishek (Chemistry & Biochemistry, 2009-09-16)Stereospecific binding of ruthenium metallointercalators with DNA is of particular interest because of the potential for improved targeting of specific sites in DNA. The present studies are focused on new metallointercalator, ... -
Investigation Of Ruthenium (II) Polypyridyl Dimers As Potential Chemotherapeutic Agents
Janaratne, Thamara K (Chemistry & Biochemistry, 2007-08-23)The exploration of transition metal complexes as chemotherapeutic agents is still a relatively unexplored but promising area of research. Chapter 1 highlights the most successful anticancer drugs and potential drugs based ... -
Investigation Of The Suitability Of The Biscatecholborate Anion As A Reductive Quencher For Photoexcited Ruthenium Polyphyridyl Complexes
Yarasik, Alper (Chemistry & Biochemistry, 2007-08-23)Ruthenium polypyridyl complexes [Ru(L-L)3]2+, (L-L = 1,10 - phenanthroline or 2,2'- bipyridine) which covalently linked to electron donor or acceptor units are frequently used in artificial photosystems because of their ... -
Investigations Of The Mechanism Of DNA Cleavage Using Ruthenium Polypyridyl Complexes
Ongeri, Fiona (Chemistry & Biochemistry, 2007-08-23)We have synthesized a ruthenium complex, [(phen)2Ru(tatpp)Ru(phen)2]4+ (P4+), which has been shown to undergo various redox and protonation steps to form different species that can be monitored by UV-Vis spectroscopy. In ... -
Light Driven Reduction Of Carbon Dioxide Via Ruthenium Polypyridyl Complexes In The Presence Of A Pyridinium Cocatalyst
West, MatthewThe rapid increase in atmospheric carbon dioxide since the industrial revolution is now beginning to cause global climate changes which could adversely affect our planets ecosystem. Nonetheless, our ability to sustain the ... -
Photo-driven One And Two-electron Processes Of Tetraazatetrapyridopentacene And Substituted Dipyridophenazine Ligands In The Presence Or Absence Of Zinc And Ruthenium Complexation
Aslan, Joseph M.Herein, we report the interaction of light with Zn(II) and Ru(II) adducts of the polypyridal ligands tetraazatetrapyridopentacene (tatpp) and dipyridophenazine (dppz). For examples where Zn(II) is coordinated to tatpp and ... -
Redox Active Lipophilic Ruthenium Complexes As Potential Anti-cancer Drugs
Alatrash, NaghamThe dinuclear ruthenium(II) polypyridyl complexes (RPCs) [(phen)2Ru(tatpp)Ru(phen)2][PF6]4 (P4+) and the monomeric [(phen)2Ru(tatpp)]Cl2 (MP2+) are promising candidates for anti-cancer drug development in terms of the ... -
RHENIUM(I) COMPLEXES OF TETRAAZATETRAPYRIDOPENTACENE (TATPP): SYNTHESIS, CHARACTERIZATION, REACTIVITY, ANTICANCER POTENTIAL AND LUMINESCENT PROBE TO DETERMINE CELLULAR LOCALIZATION
Ahuja, Pooja (2016-05-19)The ruthenium polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]4+ ([P]4+) and [(phen)2Ru(tatpp)]2+ ([MP]2+) are promising anti-tumor agents that arrest H358 NSCLC tumor growth in mouse tumor models and show cytotoxicity ... -
Ruthenium(II) Polypyridyl Complexes As Potential Anticancer Drugs: Synthesis, Characterization, Cell Permeability And Localization
Chen, Yanling (Chemistry & Biochemistry, 2013-07-22)Research on biological activities of ruthenium polypyridyl complexes (RPCs) continues to attract interest as these complexes have shown promising anticancer activity both in vitro and in vivo.¹⁻³ The mononuclear ...