Browsing Dissertations & Theses by Title
Now showing items 1-20 of 246
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3,5-Bis(3,5-bis(trifluoromethyl)phenyl)pyrazolyl complexes of Coinage Metals
(2018-05-16)Pyrazoles are an important class of five membered heterocyclic compounds consisting of two nitrogen atoms. Pyrazolate anions serve as useful ligands in coordination chemistry. When fluorinated substituents are attached to ... -
A Continuously Renewed Copper Electrode for Constant-Potential Amperometry
(2022-12-09)Pulsed amperometric detection (PAD) is a well-established technique used for the detection of electroactive compounds following Ion Chromatography (IC). Target analytes, such as carbohydrates and amino acids, typically ... -
ADVANCES IN LIQUID CHROMATOGRAPHY AND LIQUID CHROMATOGRAPHY MASS SPECTROMETRY FOR THE ANALYSIS OF BIOLOGICALLY IMPORTANT PHARMACEUTICALS, GLYCOSAMINOGLYCANS AND AMINO ACIDS
(2019-05-14)The use of high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) is now commonplace among pharmaceutical laboratories. They are major analytical tools in the drug discovery ... -
ADVANCES IN LIQUID CHROMATOGRAPHY AND LIQUID CHROMATOGRAPHY- MASS SPECTROMETRY FOR THE CHIRAL ANALYSIS OF AMINO ACIDS AND DIFFERENTIATION OF ISOMERIC AMINO ACID RESIDUES IN PEPTIDES/PROTEINS FROM COMPLEX MATRICES
(2019-11-20)Amino acids are essential building blocks in all living organisms. Initially it was believed that only L-amino acids were relevant in higher organisms, and D-amino acids were laboratory artifacts. Today, various D-amino ... -
ADVANCES IN SEPARATION AND DETECTION IN OPEN TUBULAR CHROMATOGRAPHY
Ion chromatography is an important method of analysis in the field of analytical chemistry with applications in a wide variety of applications from pharmaceutical analysis to purity assurance in semiconductor raw materials. ... -
Advances in Separation Methodologies: Fatty Acid, Fatty Amine, Water, and Ethanol Determination by Ionic Liquid Gas Chromatography and D-Amino Acid Evaluation in Mammalian Brain by Liquid Chromatography
(2016-08-15)This dissertation focuses on two chromatographic techniques, gas chromatography (GC) and high performance liquid chromatography (HPLC). The goal of the GC work is to describe advances in separation methodologies focusing ... -
An Investigation of Peak Shape Models in Chiral Separations
(2023-05-04)The use of superficially porous particles in chromatography has led to significant improvements in separation efficiency. However, peak asymmetry in enantiomeric separations causes performance comparisons across particle ... -
ANALYSIS OF ISOTOPIC ISOMERS BY GAS CHROMATOGRAPHY AND MOLECULAR ROTATIONAL RESONANCE SPECTROSCOPY AND ENANTIOSELECTIVE METHOD DEVELOPMENT BY LIQUID CHROMATOGRAPHY
(2023-05-22)**Please note that the full text is embargoed until 05/14/2024** ABSTRACT: This dissertation focuses on developing improved methods and a better understanding of gas and liquid chromatographic separation of isotopic isomers ... -
Analytical Characterization Of Anthocyanins From Natural Products By Reverse-phase Liquid Chromatography-photodiode Array-electrospray Ionization-ion Trap-time Of Flight Mass Spectrometry
(Chemistry & Biochemistry, 2011-03-03)Anthocyanins are known to be one of the most powerful phytochemical antioxidant and believed to have a positive influence on a variety of health conditions. Numerous studies continue on these compounds that are readily ... -
ANALYTICAL METHODS FOR SOLVING COMPLEX PROBLEMS IN FOOD AND ENVIRONMENTAL SCIENCE
(2019-08-28)Complex samples can be challenging for analysis in a number of different ways. Food and environmental samples can be particularly difficult due to their non-uniformity from sample to sample, possible unknown contents, and ... -
Anion Detection In The Positive Ion Mode Electrospray Ionization Mass Spectrometry By Use Of Cationic Ion Pairing Agents: Behavior And Applications
(Chemistry & Biochemistry, 2013-07-22)Anion detection and quantitation has long been of great interest to many scientific areas of research in academic and industrial settings. Their importance extends to areas such as water and environmental analysis, biological ... -
ANTIBACTERIAL DRUG DESIGN AND DISCOVERY VIA VITAMIN B1 BIOSYNTHETIC PATHWAY
(2016-08-15)Antibiotics play a vital role in fighting infectious disease caused by bacterial species. Antimicrobial resistance has been shown for every current antibiotic and poses a major health risk. To combat these growing threats ... -
APPLICATION OF DFT-DERIVED RELATIONSHIPS BETWEEN CHEMICAL ENVIRONMENT AND ²⁹Si NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY TO DETERMINE STRUCTURE IN SILICON OXYCARBIDE CERAMICS
(2017-05-15)Silicon oxycarbide (SiCO) is an amorphous ceramic material widely used in industrial applications, for its useful electronic and biologically-compatible properties.1-3 SiCO is resistant to crystallization, remaining amorphous ... -
APPLICATION OF NOVEL HETEROSUBSTITUTED VINYLIMIDAZOLES: AN APPROACH EN ROUTE TO THE TOTAL SYNTHESIS OF AXINELLAMINE A
(2016-05-11)Our group is primarily interested in the total synthesis of oroidin-based pyrrole-imidazole-containing marine sponge-derived alkaloids. These pyrrole-imidazole natural products are a growing class of alkaloids with exotic ... -
Application Of Pd-catalyzed Reactions In The Total Synthesis Of Oroidin-derived Alkaloids
(Chemistry & Biochemistry, 2014-03-17)The oroidin family of marine natural products is a growing group of sponge-derived alkaloids which contain 2-aminoimidazole and pyrrolecarboxamide fragments as their signature features. Due to their structural diversity ... -
Applications Of Circular Dichroism (CD) Spectroscopy As An Educational Tool For Undergraduate Students And Monitoring Protein Conformational Changes Induced By Ligand Binding
(Chemistry & Biochemistry, 2013-03-20)The work reported here provides an overview on the applications of circular dichroism (CD) spectroscopy for the study of protein secondary structure. This project has two specific goals. First, to develop and validate an ... -
Approaches Toward the Total Synthesis of Oroidin Alkaloids:Nagelamide A, C and Ageliferin
(2018-05-25)Nagelamides and ageliferin are oroidin-derived alkaloids which have gained the attention of the scientific community, because of their significant biological activity as well as the unprecedented structural diversity. Our ... -
AQUEOUS-BASED ASSOCIATED SOLVENTS FOR PROTEIN AND PEPTIDE FRACTIONATION AND PROTEIN PURIFICATION
(2022-01-03)The focus of this dissertation is studying capabilities of a novel two-phase system in enhancing protein identification in the whole-cell proteomics studies. In this document, two types of biphasic systems have been used ... -
Assemblies Of Assemblies: Supramolecular Ordering Of Nanoscopic Ruthenium Polypyridyl Building Blocks
(Chemistry & Biochemistry, 2008-04-22)Biological systems have long since perfected the development of nanoengineering. Cellular structure and machinery is based, to a significant extent, on the formation of nanometer to micron-sized assemblies of proteins. ... -
BAND GAP ENGINEERING IN TERNARY OXIDES AND SULFIDES: A ROUTE TO NEW PHOTOELECTRODES FOR SOLAR ENERGY CONVERSION
(2023-08-23)**Please note that the full text is embargoed until 08/01/2024** In recent years, there has been a growing interest in semiconductor photoelectrodes that can effectively split water into hydrogen and oxygen using sunlight. ...