PhD Dissertations - DO NOT EDIT
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Long non-coding RNAs in inflammation, macrophage activation, and inflammatory human diseases
(2023-08-28)**Please note that the full text is embargoed until 08/01/2025** Inflammation and immune signaling is central to infection and diseases. Growing evidence suggests that along with protein coding genes, long non-coding RNAs ... -
BAND GAP ENGINEERING IN TERNARY OXIDES AND SULFIDES: A ROUTE TO NEW PHOTOELECTRODES FOR SOLAR ENERGY CONVERSION
(2023-08-23)**Please note that the full text is embargoed until 08/01/2024** In recent years, there has been a growing interest in semiconductor photoelectrodes that can effectively split water into hydrogen and oxygen using sunlight. ... -
DEVELOPMENT OF QUALITATIVE AND QUANTITATIVE APPLICATIONS IN ENERGY INDUSTRY USING GAS CHROMATOGRAPHY- VACUUM ULTRAVIOLET SPECTROSCOPY
Characterization and evaluation of hydrocarbon assets, including content of linear and branched alkanes, cycloalkanes, aromatics, olefins, and naphthenes, among others, during production and distribution are very crucial ... -
STRUCTURE AND PROPERTY CALCULATIONS OF AMORPHOUS CERAMICS AND GLASSES USING DENSITY FUNCTIONAL THEORY CALCULATIONS AND EMPIRICAL POTENTIAL MOLECULAR DYNAMIC SIMULATIONS
The work in this thesis involves modeling amorphous ceramics and glasses using the tools of DFT and classical MD. Systems investigated include: metal-silicate glasses (in particular HfO2- SiO2), composite coatings (comprising ... -
ADVANCES IN SEPARATION AND DETECTION IN OPEN TUBULAR CHROMATOGRAPHY
Ion chromatography is an important method of analysis in the field of analytical chemistry with applications in a wide variety of applications from pharmaceutical analysis to purity assurance in semiconductor raw materials. ... -
RENEWED SIGNIFICANCE OF RAS GTPASES
The Ras superfamily of GTPases act as molecular switches and play a critical role in intracellular signal transduction. These GTPases cycle between an active GTP- bound form and an inactive GDP-bound form to regulate a ... -
Modeling ETR1 with Isolable Coinage Metal Complexes Supported by Partially Fluorinated, and Methylated Scorpionates
Ethylene is a small molecule that functions as a plant hormone that is closely associated with several vital plant functions ranging from germination, shoot and root growth, sex expression, fruit ripening, senescence and ... -
Computational materials chemistry: from polymer precursors to ceramics and high-pressure materials
(2022-08-17)With advances in computing power, the field of computational chemistry has flourished. Using current computational resources, atomistic simulations of billion atoms and trillions of atoms have been performed. Computational ... -
Molecular dynamics simulations of the adenylate kinase enzyme and its mutant states
(2022-12-19)Adenylate kinase (AK) is a small, monomeric enzyme present across all domains of life. It is responsible for maintaining homeostasis of an intracellular adenylate pool and catalyzes a reversible transfer of the phosphoryl ... -
SELF-ASSEMBLING PEPTIDES: FROM FUNDAMENTAL DESIGN TO THERAPEUTIC APPLICATIONS
(2022-08-16)Supramolecular peptide-based biomaterials have attracted much attention from researchers in various science and engineering fields because of the ease of synthesis and precise control over structures and physicochemical ... -
SENSTIVE ENANTIOMERIC ANALYSIS OF N-ACYL HOMOSERINE LACTONES IN BACTERIAL MATRICES
(2023-01-03)**Please note that the full text is embargoed until 12/13/2024** ABSTRACT: Communication between unicellular organism has long been studied with many facets yet to be discovered. A specific type of communication in ... -
SYNTHESIS OF ALLYLIC SYNTHONS AND APPLICATION OF PYRROLE THIOCARBOXYLIC ACIDS IN THE SYNTHESIS OF PYRROLE-IMIDAZOLE ALKALOIDS
(2022-05-17)**Please note that the full text is embargoed until 5/16/2024** ABSTRACT: The first part of this dissertation describes the synthesis of allylic compounds from terminal alkenes without the use of any catalysts or oxidants. ... -
COPPER(I) AND SILVER(I) COMPLEXES OF OLEFINS, ALKYNES, AND CYCLOPROPENES AND THEIR APPLICATIONS
(2022-05-17)**Please note that the full text is embargoed until 5/9/2024** ABSTRACT: Poly(pyrazolyl)borates are very popular ligands in organometallic chemistry due to their attractive properties. It is easy to modify the steric and ... -
Synthesis and Function of Ion-Selective Single-Molecule Fluorescent Imaging Molecules and Materials
(2022-05-18)Neutrinos are fermion subatomic particles that interact only by weak subatomic forces—making them almost impossible to detect. However, they can be produced in specific radioactive decay reactions, such as beta decay. We ... -
TEMPERATURE-PRESSURE PHASE DIAGRAMS OF METAL NITROGEN COMPOUNDS THROUGH DENSITY FUNCTIONAL THEORY COMPUTATIONS AND THERMODYNAMIC CALCULATIONS
(2021-12-20)The need for novel materials for new generations of applications is growing tremendously. One of many pathways to attain new materials is the route of high pressure synthesis. A particular active area in this high–pressure ... -
Multinuclear copper(I) and silver(I) pyrazolates: synthesis, luminescence, and catalysis
(2021-12-08)Copper and silver pyrazolate complexes have numerous fascinating properties such as luminescence, catalytic ability, and complexation with small molecules. Using both more widely studied non-fluorinated pyrazolates and ... -
Total Synthesis of Imidazole-Containing β-Carboline Alkaloids and Pyrrole-Imidazole Alkaloids
(2021-12-20)The first part in this dissertation focuses on the development of an enantioselective total synthesis of villagorgin A, from another natural product haploscleridamine. Haploscleridamine was targeted first as it was thought ... -
AQUEOUS-BASED ASSOCIATED SOLVENTS FOR PROTEIN AND PEPTIDE FRACTIONATION AND PROTEIN PURIFICATION
(2022-01-03)The focus of this dissertation is studying capabilities of a novel two-phase system in enhancing protein identification in the whole-cell proteomics studies. In this document, two types of biphasic systems have been used ... -
FLUOROALCOHOL INDUCED SUPRAMOLECULAR BIPHASIC SYSTEMS OF ZWITTERIONIC SURFACTANTS, MIXED AMPHIPHILES, AND POLAR ORGANIC SOLVENTS IN PROTEOMICS AND ENVIRONMENTAL ANALYSIS
(2021-12-17)In this research, we have investigated several HFIP-induced biphasic systems of zwitterionic surfactants like CHAPS and DMMAPS and their mixed amphiphilic systems for the extraction, enrichment, and fractionation of mixture ... -
IMPROVED FISCHER-TROPSCH SYNTHESIS BY THERMAL MANAGEMENT OF THE CATALYST
(2021-08-10)The research in this dissertation consists of a novel catalyst design which is aimed at helping manage the temperature instabilities and heat-transfer within a catalyst particle and maintaining an isothermal temperature ...