Browsing Theses and Dissertations(library) by Author "Griffith, Cynthia Ann"
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CELL-FREE STUDIES OF CATALYTIC DNA CLEAVAGE BY RUTHENIUM POLYPYRIDYL COMPLEXES (RPCS) CONTAINING REDOX-ACTIVE INTERCALATING LIGANDS, ENANTIOMERIC SEPARATION AND SEMI-PREP SCALE PURIFICATION OF RPCS
Griffith, Cynthia Ann; 0000-0002-3851-0810 (2018-08-28)Herein, we report the ruthenium (II) polypyridyl complexes (RPCs), [(phen)₂Ru(tatpp)] ²⁺ (3²⁺) and [(phen)₂Ru(tatpp)Ru(phen)₂] ⁴⁺ (4⁴⁺) are shown to cleave DNA in cell-free studies in the presence of a mild reducing agent, ... -
Towards Establishing The Mechanism Of DNA Cleavage By Redox-active Ruthenium(II) Polypyridyl Complexes
Griffith, Cynthia AnnIn earlier reports, it was established that ruthenium (II) polypyridyl complexes RPCs, [Ru(tatpp)]²⁺ (3²⁺) and [Ru(tatpp)Ru]⁴⁺ (4⁴⁺) show potent antitumor properties in vivo in nude mouse lung cancer models.² These RPC's ...