Department of Bioengineering: Recent submissions
Now showing items 21-40 of 338
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NANOPARTICLE-BASED APPROACHES IN CARDIOVASCULAR DISEASES
(2020-08-14)Percutaneous coronary intervention (PCI) such as balloon angioplasty and stent placement are commonly employed for myocardial revascularization. These strategies, however, injure the arterial wall initiating a cascade of ... -
In vivo ultrasound-switchable fluorescence imaging and its applications
(2020-08-17)The conventional fluorescence imaging has limited spatial resolution in centimeters-deep tissue because of the tissue’s high scattering property. Ultrasound-switchable fluorescence (USF) imaging, a new imaging technique, ... -
Mapping of Electroencephalogram (EEG) Responses to Newsvendor Decision Model and Cerebral Hemodynamic Responses to Transcranial Photobiomodulation (tPBM) in Humans
(2022-05-17)Decision-making is one of the most critical activities of human beings. Various studies have investigated the brain responses to a variety of decision tasks by deploying the EEG data. The first aim of my dissertation was ... -
Development of medical devices for osteoarthritis diagnosis, antimicrobial, wound closure, and wound pH milieu monitoring
(2019-12-10)Nanotechnology has been widely used in the field of biomedical engineering. For example, nanoparticles have been employed for targeted drug delivery due to their retention effect, increased permeability, site-specific ... -
LUNG CANCER TARGETED CHEMOTHERAPY VIA HERCEPTIN BASED CHIMERIC ANTIGEN RECEPTOR (CAR) ENGINEERED T CELL MEMBRANE COATED SYNTHETIC NANOPARTICLES
(2019-08-21)Cell membrane-derived nanoparticles recently caught attention due to their desirable features in drug delivery such as mimicking properties of native tissue and cells, avoiding systemic clearance, and alleviating foreign ... -
EFFECTS OF AGING ON MOUSE ROTATOR CUFF TENDON BIOMECHANICS
(2021-12-21)Rotator cuff tendon injuries and tear are caused by overuse, falling, or other accidents, and are often associated with old age. The severe injuries and tear can be debilitating and require nonsurgical treatment for partial ... -
DEVELOPMENT AND INVESTIGATION OF FLUORESCENCE IMAGING PROBES
(2019-09-03)Fluorescence imaging has attracted much attention due to high sensitivity, spatial and temporal resolution, and fast acquisition time, for imaging biomolecular processes and for diagnosis of diseases such as cancer in early ... -
Novel analysis of wavelet coherence and phase-amplitude coupling to investigate the human brain at four vigilance states
(2019-08-21)Despite breakthroughs in the field of neuroimaging, there remain many unanswered questions about brain functions and activities and their underlying physiological processes. In my dissertation research, I examined brain ... -
ULTRASOUND SWITCHABLE FLUORESCENCE IMAGING BASED ON A TIME GATED ICCD CAMERA
(2019-08-08)Ultrasound switchable fluorescence (USF) imaging has been proposed as a novel imaging modality which provides microscopic fluorescence imaging in centimeter-deep tissue. USF is possible to reveal many interesting phenomena ... -
Development of medical devices for diagnosing cartilage injury and metastatic cancers
(2019-08-07)My research focused on applying biomedical engineering techniques to diagnose different diseases and conditions. The results of these work led to one published paper and two submitted manuscripts which are summarized in ... -
APPLICATION OF TISSUE ENGINEERING TECHNIQUES FOR TREATING CARTILAGE INJURY AND DIAGNOSING CANCER METASTASIS
(2019-08-05)This study focuses on the application of tissue engineering techniques for the diagnosis of cancer metastasis, cartilage regeneration, and modeling of lymph node metastasis. Chapter 1 is an overview of tissue engineering ... -
DESIGN, DEVELOPMENT, AND VALIDATION OF A NOVEL OPTICAL IMAGING DEVICE FOR BIOMEDICAL APPLICATIONS
(2019-07-31)Fluorescence and luminescence imaging are two promising optical techniques for diagnosing a variety of critical pathologies in vivo, including wound healing, inflammation, and vascular diseases. Despite this, there is a ... -
Targeting the Oligomannose Biomarker Present on Distinct Subsets of Non-Hodgkin Lymphomas
(2020-09-04)Subtypes of B cell non-Hodgkin’s lymphomas, including follicular lymphomas, have shown a unique high oligomannose presentation on their immunoglobulins that will interact with natural receptors of the innate immunity, ... -
Microchannel technology in cancer cell confined-migration study and its application in drug screening
(2020-08-10)PDMS-based microchannel device has been explored to extend the basic platform for three-dimensional (3D) culture models of cell motility study because of its relevant stiffness and designable shape. Moreover, it is easy ... -
EVALUATION OF A PERSONAL MOBILE TRAINER SYSTEM DESIGNED FOR FACILITATING EXERCISE THERAPY FOR TRAUMATIC BRAIN INJURY PATIENTS
(2021-08-16)There are no effective pharmacological agents that can prevent or treat post-TBI cognitive deterioration. Previous research has shown that exercise can be an effective means of enhancing the patients condition with mild ... -
Localized Treatment of Malignant Melanoma Using a Modified Cellulose-Based Hydrogel Loaded with Temozolomide with Increased Safety of Human Dermal Fibroblasts and the Mechanisms Behind the Effect
(2021-08-30)Melanoma pathophysiology is highly varied, and the initial cause of tumorigenesis is still unknown, but it is likely a combination of both epigenetic and genetic means. Further, melanoma tumors have one of the highest ... -
Poly(lactic-co-glycolic acid) Nanoparticle Delivery of Notch Intracellular Domain Plasmid to Restore Notch Signaling
(2021-08-23)Notch signaling is a highly conserved signaling system that is required for embryonic development and regeneration of organs. When the signal is lost, maldevelopment occurs and leads to a lethal state. Delivering exogenous ... -
Examination Of The Effects of Confined Migration on Androgen Resistant Prostate Cancer And Potential Treatment Option for Drug Resistant PC3 Cells with Calcitriol
(2020-05-04)When localized to the prostate, prostate cancer (PCa) has a near 100% 5-year survival rate, however, when prostate cancer metastasizes the survival rate drastically drops to around 30%. The low death rate of primary PCa ... -
STUDY OF UPREGULATION OF DRUG RESISTANCE IN H460 LUNG CANCER CELLS VIA MICROCHANNEL DEVICE
(2020-05-14)Metastasis is the main reason of high mortality rates in cancer patients. Treating these patients becomes difficult once the cancer has metastasized, especially due to their drug resistance. Drug resistance is a common ... -
PHOTOBIOMODULATION AND STEM CELL DIFFERENTIATION: APPLICATION TO MODULATE ADIPOGENESIS THROUGH CELLULAR AND NUCLEAR MORPHOLOGY
(2020-05-28)Mesenchymal stem cells (MSCs) are of great interest in regenerative medicine due to their capability to self-renew and differentiate to various lineages. Typically, differentiation to specific cell types has relied on ...