Browsing PhD Dissertations - DO NOT EDIT by Issue Date
Now showing items 1-20 of 113
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Diffuse Optical Tomography To Study The Ischemic Stroke In Rat Models
(Biomedical Engineering, 05-06-2013)Stroke, including ischemic stroke and hemorrhagic stroke, is the major leading cause of death in the United States. More than 80 percent of stroke patients are diagnosed with ischemic stroke, which usually results from ... -
Establishment And Characterization Of An Animal Model Of Distraction Spinal Cord Injury
(Biomedical Engineering, 05-17-2013)Scoliosis corrective surgery requires the application of multidirectional stress forces to the spinal cord, including those of distraction, in addition to the application of fixation rods for correction of the curved spine ... -
Novel Intraocular Drug Delivery System For The Prevention Of Posterior Capsule Opacification
(Biomedical Engineering, 2007-08-23)Posterior capsule opacification (PCO) is a major complication associated with the implantation of intraocular lens (IOLs). Evidence suggests that PCO formation is caused by abnormal lens epithelial cell (LEC) migration/p ... -
Investigation Of Breast Tumor Hemodynamics By Near Infrared Spectroscopy: Applications To Cancer Therapy Monitoring
(Biomedical Engineering, 2007-08-23)Hyperoxic gas interventions using carbogen (95% O2 and 5% CO2) or oxygen has been tried to increase the tumor oxygenation since it will enhance the therapeutic effects on the tumors. Others in the laboratory had previously ... -
Tissue And Vascular Oxygenation Dynamics Determined By Optical Approaches And MRI
(Biomedical Engineering, 2007-09-17)Tumor oxygenation is a crucial factor to determine the efficiency of non-surgery therapy, such as radiotherapy and chemotherapy. Therefore, various approaches have been applied to tumor in order to improve the tumor oxygen ... -
Resolution And Localization In Single Molecule Microscopy
(Biomedical Engineering, 2007-09-19)Rayleigh's criterion is extensively used in optical microscopy to determine the resolution of microscopes. Despite its widespread use, it is well known that this criterion is based on heuristic notions and can be surpassed ... -
Development Of A Broadband Multi-channel NIRS System For Quantifying Absolute Concentrations Of Hemoglobin Derivatives And Reduced Scattering Coefficients
(Biomedical Engineering, 2008-08-08)Near infrared spectroscopy (NIRS) has been widely applied to investigate hemoglobin oxygenations of muscles, brain and breast tumors. Steady state reflectance techniques developed previously have been restricted to ... -
Magnetic Drug Targeting: Development Of A Novel Drug Delivery System For Prostate Cancer Therapy
(Biomedical Engineering, 2008-09-17)Magnetic nanoparticles (MNPs) have been attracting a great amount of attention because of their numerous applications including contrast agents in magnetic resonance imaging (MRI), magnetic targeted drug carriers, and ... -
Novel Animal Model And In Vivo Imaging System To Study Inflammatory Response-mediated Cancer Metastasis
(Biomedical Engineering, 2010-07-19)Cancer metastasis is the leading cause of death in cancer patients. A vast majority of cancer-related mortality is attributed to this rather than the primary tumor itself, making the understanding of cancer metastasis ... -
Targeted Delivery Of Carbon Nanotubes To Cancer Cells
(Biomedical Engineering, 2010-07-19)CD22 is broadly expressed on human B cell lymphomas. Monoclonal anti-CD22 antibodies (MAbs) alone, or coupled to toxins, have been used to selectively target these tumors both in severe combined immunodeficient (SCID) mice ... -
Enhanced Endothelialization On Surface Modified Poly(L-lactic Acid)
(Biomedical Engineering, 2010-07-19)Current synthetic vascular grafts and polymer-coated drug-eluting stents (DES) have certain limitations, such as thrombosis and restenosis due to the incomplete recovery of vascular endothelial cells on their luminal sides. ... -
Mechanisms Of Biomaterial Mediated Fibrotic Responses And Strategies To Improve Tissue Reactions To Biomaterial Implants
(Biomedical Engineering, 2010-07-19)Despite considerable advancements in biomaterial synthesis and modification techniques, most tissue engineering scaffolds elicit fibrotic reactions resulting in implant encapsulation, secluding cells and/or therapeutic ... -
Advances In Helical Stent Design And Fabrication: Studies Of Stent Thermal Treatment, Stent Mechanical Properties, And Stent Interactions With A Simulated Plaque-laden Artery
(Biomedical Engineering, 2010-11-01)Advancements in processing biomaterials have lead to the development of bioresorbable PLLA drug-loaded stents with different geometric configurations. To further advance the technology, systematic studies have been carried ... -
Multi-ligand Nanoparticles For Targeted Drug Delivery To The Injured Vascular Wall
(Biomedical Engineering, 2010-11-01)Pathological conditions like coronary artery disease, acute myocardial infarction, stroke, and peripheral artery diseases as well as cardiovascular interventions used in the treatment of coronary artery diseases such as ... -
Development Of Orchestrated Stem Cell-based Regeneration (OSCeR) -strategies To Recruit And Differentiate Autologous Stem Cells For Tissue Regeneration
(Biomedical Engineering, 2011-03-03)Stem cell therapy has shown great promise in curing diseases. However, clinical application of stem cell therapy is often hindered by the lack of reliable sources and convenient methods to recover stem cells. Our laboratory ... -
Novel ¹H MR Probes To Interrogate The Tumor Microenvironment
(Biomedical Engineering, 2011-10-11)The term "tumor microenvironment" usually refers to the description of the physiological and metabolic conditions within solid tumors (primary or metastatic), and is significantly different from that of normal tissues. ... -
Wireless Closed-loop Feedback Systems For Automatic Detection And Suppression Of Nociceptive Signals
(Biomedical Engineering, 2011-10-11)Chronic pain is an important public health issue. Several approaches have been implemented for management of chronic pain, including surgical implantation of neurostimulators. Neurostimulators have been used in clinics for ... -
Investigation Of Neural Correlates Between Perception Of Pain And Hemodynamic Response Measured In The Pre-frontal Cortex Using Functional Near Infra-red Spectroscopy
(Biomedical Engineering, 2011-10-11)Perception of pain is multi-dimensional, comprising three major psychological dimensions: sensory-discriminative, motivational-affective and cognitive-evaluative. This dissertation study investigates the cognitive evaluation ... -
Novel Applications Of Compressed Sensing To Magnetic Resonance Imaging And Spectroscopy
(Biomedical Engineering, 2012-04-11)In this work, three novel applications of compressed sensing to MRI have been developed and implemented which accomplish reduction in acquisition time, thereby also enabling increased spatial and/or temporal resolution. ... -
Methodology Of Citrate-based Biomaterial Development And Application
(Biomedical Engineering, 2012-04-11)Biomaterials play central roles in modern strategies of regenerative medicine and tissue engineering. Attempts to find tissue-engineered solutions to cure various injuries or diseases have led to an enormous increase in ...