Browsing PhD Dissertations - DO NOT EDIT by Title
Now showing items 1-20 of 113
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A Liver-Kidney Biosubsystem
(2017-05-04)Each year many patients die waiting for a transplant organ to become available. Increasing the available number of transplant organs would save lives. The donor pool could be expanded if organs which are considered to be ... -
Advances In Helical Stent Design And Fabrication: Studies Of Stent Thermal Treatment, Stent Mechanical Properties, And Stent Interactions With A Simulated Plaque-laden Artery
(Biomedical Engineering, 2010-11-01)Advancements in processing biomaterials have lead to the development of bioresorbable PLLA drug-loaded stents with different geometric configurations. To further advance the technology, systematic studies have been carried ... -
ADVANCING THE RADIATION ONCOLOGY CLINIC WITH MOTION MANAGEMENT AND AUTOMATIC TREATMENT PLANNING
(2022-06-09)The leading cause of premature death (death under the age of 70) is cancer. The top five cancers for both male and female are: lung, colorectum, pancreas, breast cancer, and prostate. In 2020 there was an estimated 19.3 ... -
AN ACTOMYOSIN DRIVEN, PRESSURE BASED ADHESION MODEL OF CONFINED GLIOBLASTOMA MULTIFORME CELL MIGRATION
(2016-05-13)Glioblastoma multiforme (GBM) is the most aggressive and common form of glial tumors arising in the support cells of the brain. Cell migration plays a critical role in undermining the surgical resection of tumors. ... -
An In vitro 3D Model to Investigate IOL: Posterior Lens Capsule Interactions on Lens Epithelial Cell Responses
(2023-01-18)**Please note that the full text is embargoed until 12/19/2024** ABSTRACT: Posterior Capsule Opacification (PCO) is the most common complication associated with Intraocular Lens (IOL) implantation. The disease is caused ... -
AN IN VITRO MODEL TO STUDY THE ROLE OF IOL: LENS CAPSULE INTERACTIONS IN POSTERIOR CAPSULE OPACIFICATION
(2021-05-05)Posterior capsule opacification (PCO) is the most common complication associated with intraocular lens (IOL) implantation. Unfortunately, current in vitro models cannot be used to assess the potential of PCO due to their ... -
Application Of Scanning Correlation Spectroscopy Techniques To Quantify DNA Double Strand Break Repair Kinetics In The Living Cell After Exposure To γ-rays And Radiomimetic Chemicals
(Biomedical Engineering, 2013-03-20)The kinetics of most proteins involved in DNA damage sensing, signaling and repair following ionizing radiation exposure cannot be quantified by current live cell fluorescence microscopy methods. This is because most of ... -
APPLICATION OF TISSUE ENGINEERING TECHNIQUES FOR TREATING CARTILAGE INJURY AND DIAGNOSING CANCER METASTASIS
(2019-08-05)This study focuses on the application of tissue engineering techniques for the diagnosis of cancer metastasis, cartilage regeneration, and modeling of lymph node metastasis. Chapter 1 is an overview of tissue engineering ... -
Biliary Tract Differentiation Through Use Of Visible To NIR Hyperspectral Reflectance Imaging
(Biomedical Engineering, 2014-09-17)Cholecystectomies are one of the most common surgeries performed in the United States, and most of the complications which arise from these are injuries to the common bile duct (CBD) resulting from a misidentification of ... -
BIOMECHANICAL STUDIES OF DEVELOPING ZEBRAFISH HEART IN-VIVO
(2021-05-05)The heart is an electrically controlled mechanical pump that provides the cardiac output required by the body to function properly and flexibly adapts to changing demand and working conditions. In vertebrate embryos, the ... -
Cell Specific Guidance Of Nerve And Vascular Regeneration Through Sustained Growth Factor Release
(Biomedical Engineering, 2014-09-17)Regenerative peripheral nerve interfaces have been proposed as viable alternatives for the natural control of robotic prosthetic devices. However, sensory and motor axons at the neural interface are of mixed submodality ... -
CENTIMETER-DEEP TISSUE FLUORESCENCE MICROSCOPIC IMAGING
(2016-07-26)Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information—such as microcirculation, tumor angiogenesis, and cancer metastasis—may ... -
Computer Vision Algorithm Development and Biomedical Applications
(2016-05-10)Supervising Professor: Liping Tang and Weihua Mao This study focuses on the development and analysis of novel computer vision algorithms for biomedical applications. Chapter 2 focuses on developing a 2D Canny edge-based ... -
Creep Response and Adhesion Dynamics of Glioblastoma Multiforme Cells During Migration in Confined Environment
(2018-05-10)Glioblastoma multiforme (GBM) is the most common and malignant form of primary brain tumor. One of the major challenges facing the treatment of GBM tumors is the detachment and subsequent migration of peripheral cells. ... -
DESIGN, DEVELOPMENT, AND VALIDATION OF A NOVEL OPTICAL IMAGING DEVICE FOR BIOMEDICAL APPLICATIONS
(2019-07-31)Fluorescence and luminescence imaging are two promising optical techniques for diagnosing a variety of critical pathologies in vivo, including wound healing, inflammation, and vascular diseases. Despite this, there is a ... -
Designing and advancing contrast agents for ultrasound-switchable fluorescence imaging
(2021-12-09)Fluorescence imaging is a remarkable tool for molecular targeting and multicolor imaging, but it suffers from poor resolution in centimeters-deep tissues. The recently developed ultrasound-switchable fluorescence (USF) ... -
Detection of Molecular Biomarkers involved in the Induction of EMT, migration and invasion, and drug resistance in breast cancer cells in 3D confinement
(2018-09-17)Standard-of-care regimes for cancer treatment have become more effective and sophisticated over the last decade due to research developments which facilitate specific targeting of treatments to certain cancers, and the ... -
DEVELOPMENT AND INVESTIGATION OF FLUORESCENCE IMAGING PROBES
(2019-09-03)Fluorescence imaging has attracted much attention due to high sensitivity, spatial and temporal resolution, and fast acquisition time, for imaging biomolecular processes and for diagnosis of diseases such as cancer in early ... -
Development Of A Broadband Multi-channel NIRS System For Quantifying Absolute Concentrations Of Hemoglobin Derivatives And Reduced Scattering Coefficients
(Biomedical Engineering, 2008-08-08)Near infrared spectroscopy (NIRS) has been widely applied to investigate hemoglobin oxygenations of muscles, brain and breast tumors. Steady state reflectance techniques developed previously have been restricted to ... -
Development of Algorithms to Analyze Electrogastrography (EGG) for Neonatal Gastrointestinal Development and Electroencephalography (EEG) for Effects of LED-based Pre-frontal Light Stimulation
(2022-05-17)Algorithm development, and biological signal processing are the key components for new applications of successful medical diagnosis that can provide physiological and functional information to better understand human ...