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dc.contributor.authorKribs, Christopher
dc.contributor.authorDel Valle, Sara
dc.contributor.authorMorales Evangelista, Arlene
dc.contributor.authorVelasco, Maria Cristina
dc.contributor.authorHsu Schmitz, Shu-Fang
dc.date.accessioned2016-05-19T16:49:23Z
dc.date.available2016-05-19T16:49:23Z
dc.date.issued2004
dc.identifier.citationPublished in Mathematical Biosciences 187(2):111-133, Feb. 2004en_US
dc.identifier.urihttp://hdl.handle.net/10106/25668
dc.descriptionAuthor's final draft after peer review, also known as a post print.en_US
dc.description.abstractGenetic studies report the existence of a mutant allele Δ32 of CC R5 chemokine receptor gene at high allele frequencies ( 10%) in Caucasian populations. The presence of the allele is believed to provide partial or full resistance to HIV. In this study, we look at the impact of education, temporarily effective vaccines and therapies on the dynamics of HIV in homosexually active populations. In our model, it is assumed that some individuals possess one or two mutant alleles (like Δ32 of CCR5) that prevent the successful invasion or replication of HIV. Our model therefore differentiates by genetic and epidemiological status and naturally ignores the reproduction process. Furthermore, HIV infected individuals are classified as rapid, normal or slow progressors. In this complex setting, the basic reproductive number Ro is derived in various situations. The separate or combined effects of therapies, education, vaccines, and genetic resistance are analyzed. Our results support the conclusions of Hsu Schmitz that some integrated intervention strategies are far superior to those based on a single approach. However, treatment programs may have effects which counteract each other, as may genetic resistance.en_US
dc.description.sponsorshipThis study was supported by the following institutions and grants: National Science Foundation (NSF Grant DMS-9977919); National Security Agency (NSA and Grants MDA 904-00-1-0006); Sloan Foundation: Cornell-Sloan National Pipeline Program in the Mathematical Sciences; and the Office of the Provost of Cornell University.en_US
dc.language.isoen_USen_US
dc.subjectHIV/AIDSen_US
dc.subjectGenetic resistanceen_US
dc.subjectVaccinationen_US
dc.subjectTreatment program
dc.subjectPublic education
dc.subjectReproductive number
dc.titleEffects of education, vaccination and treatment on HIV transmission in homosexuals with genetic heterogeneityen_US
dc.typeArticleen_US
dc.publisher.departmentDepartment of Mathematics, University of Texas at Arlington
dc.identifier.externalLinkDescriptionThe original publication is available at Article DOI
dc.identifier.doihttp://dx.doi:10.1016/j.mbs.2003.11.004


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