Investigation of Copper Cysteamine Nanoparticles as a New Type of Radiosensitiers for Colorectal Carcinoma Treatment
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Date
2017-08-24Author
Liu, Zhipeng
Xiong, Li
Ouyang, Guoqing
Ma, Lun
Sahi, Sunil
Wang, Kunpeng
Lin, Liangwu
Huang, He
Miao, Xiongying
Chen, Wei
Wen, Yu
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Copper Cysteamine (Cu-Cy) is a new photosensitizer and a novel radiosensitizer that can be activated
by light, X-ray and microwave to produce singlet oxygen for cancer treatment. However, the killing
mechanism of Cu-Cy nanoparticles on cancer cells is not clear yet and Cu-Cy nanoparticles as novel
radiosensitizers have never been tested on colorectal cancers. Here, for the frst time, we investigate
the treatment efciency of Cu-Cy nanoparticles on SW620 colorectal cells and elucidate the underlying
mechanisms of the efects. The results show that X-ray activated Cu-Cy nanoparticles may kill SW620
cancerscells is in a dose-dependent manner. The JC-1 staining shows the mitochondrial membrane
potential is decreased after the treatment. The observations confrm that Cu–Cy nanoparticles may
improve X-ray radiotherapy on cancer treatment and X-ray activated Cu-Cy nanoparticles can be
efciently destroy colorectal cancer cells by inducing apoptosis as well as autophagy. As a new type of
radiosensitizers and photosensitizers, Cu-Cy nanoparticles have a good potential for colorectal cancer
treatment and the discovery of autophagy induced by X-ray irradiated Cu-Cy nanoparticles sheds a good
insight to the mechanism of Cu-Cy for cancer treatment as a new radiosensitizers.
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