dc.contributor.author | Kandukuri, Jayanth | |
dc.contributor.author | Yu, Shuai | |
dc.contributor.author | Cheng, Bingbing | |
dc.contributor.author | Bandi, Venugopal | |
dc.contributor.author | D’Souza, Francis | |
dc.contributor.author | Nguyen, Kytai Truong | |
dc.contributor.author | Hong, Yi | |
dc.contributor.author | Yuan, Baohong | |
dc.contributor.editor | Gobalakrishnan, Sundaresan | en_US |
dc.contributor.editor | Zweit, Jamal | |
dc.date.accessioned | 2018-04-12T00:57:01Z | |
dc.date.available | 2018-04-12T00:57:01Z | |
dc.date.issued | 4 February 2017 | |
dc.identifier.citation | Published in the International Journal of Molecular Sciences 18(2): 1-14, 2017 | en_US |
dc.identifier.uri | http://hdl.handle.net/10106/27314 | |
dc.description.abstract | Simultaneous imaging of multiple targets (SIMT) in opaque biological tissues is an important goal for molecular imaging in the future. Multi-color fluorescence imaging in deep tissues is a promising technology to reach this goal. In this work, we developed a dual-modality imaging system by combining our recently developed ultrasound-switchable fluorescence (USF) imaging technology with the conventional ultrasound (US) B-mode imaging. This dual-modality system can simultaneously image tissue acoustic structure information and multi-color fluorophores in centimeter-deep tissue with comparable spatial resolutions. To conduct USF imaging on the same plane (i.e., x-z plane) as US imaging, we adopted two 90 <degree>-crossed ultrasound transducers with an overlapped focal region, while the US transducer (the third one) was positioned at the center of these two USF transducers. Thus, the axial resolution of USF is close to the lateral resolution, which allows a point-by-point USF scanning on the same plane as the US imaging. Both multi-color USF and
ultrasound imaging of a tissue phantom were demonstrated. | en_US |
dc.description.sponsorship | This work was supported in part by funding from the NSF CBET-1253199 (Baohong Yuan), the NHARP 13310 (Baohong Yuan), the NIH/NIBIB 7R15EB012312-02 (Baohong Yuan), the CPRIT RP120052/170564(Baohong Yuan). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Attribution 4.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/us/ | * |
dc.subject | Imaging -- Fluorescence -- Deep tissue | en_US |
dc.subject | Molecular imaging | en_US |
dc.subject | Ultrasound imaging | en_US |
dc.title | A Dual-Modality System for Both Multi-Color Ultrasound-Switchable Fluorescence and Ultrasound Imaging | en_US |
dc.type | Article | en_US |
dc.publisher.department | Department of Bioengineering, The University of Texas at Arlington | en_US |
dc.identifier.externalLinkDescription | Original article is available at the article DOI | en_US |
dc.identifier.doi | doi:10.3390/ijms18020323 | |