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Application Of Pd-catalyzed Reactions In The Total Synthesis Of Oroidin-derived Alkaloids
(Chemistry & Biochemistry, 2014-03-17)
The oroidin family of marine natural products is a growing group of sponge-derived alkaloids which contain 2-aminoimidazole and pyrrolecarboxamide fragments as their signature features. Due to their structural diversity ...
Mixed Lineage Leukemia Histone Methylases In Hormonal Regulation Of HOX Genes And Their Disruption By Endocrine Disrupting Chemicals
(Chemistry & Biochemistry, 2014-03-10)
Homeobox (HOX) genes are highly conserved family of genes that play vital roles during cell differentiation and embryogenesis. Of the 39 HOX genes present in human, HOXC6 is a critical players in mammary gland development, ...
Total Synthesis Of Marine Derived Natural Products: Kealiiquinone And Ageliferin
(Chemistry & Biochemistry, 2014-03-17)
An intramolecular Diels-Alder reaction of vinylimidazoles has been developed and applied towards the total synthesis of benzimidazole and tetrahydrobenzimidazole natural products, namely kealiiquinone and ageliferin. A ...
Mixed Lineage Luekemia Histone Methyltransferases In Hormonal Regulation Of HOXB9 And Target Gene Regulation
(Chemistry & Biochemistry, 2014-09-17)
Homeobox gene (HOX) genes are evolutionary conserved genes that play important roles in cell differentiation, cell proliferation and embryogenesis. HOX genes bind to the DNA via their homeodomain and act as transcription ...
Examining Ruthenium Chromophores For The Photochemical Reduction Of CO₂To Methanol
(Chemistry & Biochemistry, 2014-03-12)
Our consumption of energy for transportation and electricity has been growing as quickly as our population. As this demand for energy increases we increase our production of carbon dioxide by the burning of fossil fuels ...
Fundamental And Applied Studies Of An Ambient Ionization Technique: Continuous Flow-extractive Desorption Electrospray Ionization - Mass Spectrometry
(Chemistry & Biochemistry, 2014-07-14)
Continuous flow extractive desorption electrospray ionization (CF-EDESI) is a novel ambient ionization technique that was developed to help analyze samples from non-ESI-friendly solvents, manipulate protein charge states, ...
Development Of Paired Ion Electrospray Ionization Mass Spectrometry For Ultrasensitive Detection Of Anions
(Chemistry & Biochemistry, 2014-09-17)
Mass spectrometry (MS) has emerged as an essential analytical technique over the last several decades. It is a widely applicable and powerful tool for determination and identification of different types of molecules. ...
The Use Of Liquid Chromatography And Subcritical Fluid Chromatography For Chiral Separations Using Macrocyclic Chiral Stationary Phases: Insights Into Mechanisms Of Retention And Chiral Discrimination
(Chemistry & Biochemistry, 2014-09-17)
Enantiomeric separations are an essential component of pharmaceutical drug development, not only at the analytical scale, but also to separate usable quantities for further analysis. The field of asymmetric synthesis is ...
Synthetic Strategies To Probe Enzymatic Activity: Investigation Of A Novel Oxygen-dependent Non-heme Diiron Monooxygenase (MiaE)
(Chemistry & Biochemistry, 2014-09-17)
Within the anticodon stem loop (ACSL) of tRNA, nucleoside modifications are frequently observed at position 34 (the wobble position) or position 37 (3' adjacent to the anticodon). For instance, nearly all eukaryotic and ...
Crystalline SiCO: Implication On Structure And Thermochemistry Of Ternary Silicon Oxycarbide Ceramics
(Chemistry & Biochemistry, 2014-09-17)
The need for innovative refractory materials - materials that can sustain extreme temperatures - has been constantly growing within the modern industries. Basic requirements for usage at ultra-high-temperatures have been ...