Department of Chemistry and Biochemistry: Recent submissions
Now showing items 21-40 of 247
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AQUEOUS-BASED ASSOCIATED SOLVENTS FOR PROTEIN AND PEPTIDE FRACTIONATION AND PROTEIN PURIFICATION
(2022-01-03)The focus of this dissertation is studying capabilities of a novel two-phase system in enhancing protein identification in the whole-cell proteomics studies. In this document, two types of biphasic systems have been used ... -
FLUOROALCOHOL INDUCED SUPRAMOLECULAR BIPHASIC SYSTEMS OF ZWITTERIONIC SURFACTANTS, MIXED AMPHIPHILES, AND POLAR ORGANIC SOLVENTS IN PROTEOMICS AND ENVIRONMENTAL ANALYSIS
(2021-12-17)In this research, we have investigated several HFIP-induced biphasic systems of zwitterionic surfactants like CHAPS and DMMAPS and their mixed amphiphilic systems for the extraction, enrichment, and fractionation of mixture ... -
IMPROVED FISCHER-TROPSCH SYNTHESIS BY THERMAL MANAGEMENT OF THE CATALYST
(2021-08-10)The research in this dissertation consists of a novel catalyst design which is aimed at helping manage the temperature instabilities and heat-transfer within a catalyst particle and maintaining an isothermal temperature ... -
Developing chemo-proteomics methods for tyrosine conjugation and studies of organometallic complexes of gold.
(2023-05-22)**Please note that the full text is embargoed until 05/14/2025** ABSTRACT: The incredible changes in MS instrumentation since the late 1980s with the advent of electrospray ionization (ESI) and matrix-assisted laser ... -
ANALYSIS OF ISOTOPIC ISOMERS BY GAS CHROMATOGRAPHY AND MOLECULAR ROTATIONAL RESONANCE SPECTROSCOPY AND ENANTIOSELECTIVE METHOD DEVELOPMENT BY LIQUID CHROMATOGRAPHY
(2023-05-22)**Please note that the full text is embargoed until 05/14/2024** ABSTRACT: This dissertation focuses on developing improved methods and a better understanding of gas and liquid chromatographic separation of isotopic isomers ... -
EPIMERIC PEPTIDES IN ALZHEIMER’S DISEASE: IMPLICATIONS FOR LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY AND IMMUNOTHERAPIES
(2023-05-19)Evidence has shown that the extracellular deposition of amyloid-beta (Aβ) peptide is a contributing factor of Alzheimer’s disease. Further, modifications to Aβ peptides may enhance the deposition of Aβ plaques and/or ... -
COMBINING CHIRAL CHROMATOGRAPHIC STATIONARY PHASES AND N-DERIVATIZATION STRATEGIES FOR THE QUALITATIVE AND QUANTITATIVE ANALYSIS OF D-AMINO ACIDS, D-AMINO ACID CONTAINING PEPTIDES AND D-AMINO ACID RELATED SECONDARY METABOLITES USING LIQUID CHROMATOGRAPHY
(2023-05-12)Amino acids are essential building blocks in all life on Earth. It was first mistakenly believed that only L-amino acids were of biological relevance in higher organisms, and D-amino acids were laboratory artifacts or ... -
An Investigation of Peak Shape Models in Chiral Separations
(2023-05-04)The use of superficially porous particles in chromatography has led to significant improvements in separation efficiency. However, peak asymmetry in enantiomeric separations causes performance comparisons across particle ... -
Nitroalkane Oxidase Inspired NO-Transfer Agents, NO Sensors, and the Computational Design of Fluorescent Sensors
(2023-03-13)**Please note that the full text is embargoed until 2/25/2025** ABSTRACT: Flavin adenine dinucleotide and flavin mononucleotide are co-enzymes with biologically relevant redox potentials. They are involved in many chemical ... -
Development of Colorimetric and Fluorescent Antibiotic Biosensors and Synthesis of Drug-Related Biomimetic Molecules for Calcium Carbonate Polymorph Control and Stabilization
(2022-12-19)Polydiacetylene (PDA) polymers are conjugated macromolecules with desirable sensing properties. The presence of alternate double and triple bonds (en-yne subunits) generates electron delocalization in the PDA backbone, ... -
Probing Short-Range Structural Distortion of Stereochemically Active Lone Pairs in Extended Solid-State Materials
(2022-12-20)The structural and electronic effects of the lone pairs play an important role in magnetic, photocatalytic, and semiconducting behaviors of materials. Investigating the role of stereochemically active ns2 lone pairs derived ... -
A Continuously Renewed Copper Electrode for Constant-Potential Amperometry
(2022-12-09)Pulsed amperometric detection (PAD) is a well-established technique used for the detection of electroactive compounds following Ion Chromatography (IC). Target analytes, such as carbohydrates and amino acids, typically ... -
Stimuli-Responsive Peptide Self-Assembly for Therapeutic Delivery
(2022-08-16)Peptide self-assembly offers an effective method to generate supramolecular nanomaterials with much higher stability than traditional monomeric peptides. The materials exhibit well-organized hierarchical structures and ... -
Chemically Modified Cyclofructans for Sub/supercritical Fluid Chromatography and Hydrophilic Interaction Liquid Chromatography
(2022-08-16)Given the importance of supercritical fluid chromatography, several works focused on the application use different SFC stationary phases. In this work, two new derivatized cyclofructan bonded phases with superficially ... -
LnCrTeO6 (Ln= La, Pr, Nd) octahedral distortions and optical characterization
(2022-08-17)LnCrTeO6 (La, Pr, Nd) compounds are suspected to appear as vibrant blue-green colored materials. LnCrTeO6 (La, Pr, Nd) were synthesized to analyze the local coordination environments of Ln3+, Cr3+, and Te6+ cations. ... -
Synthetic studies on oxidative dearomatization reactions and applications in synthesis of the KB343 core structure, and investigation of bioactive thiazolidines
(2022-08-16)Natural products have inspired researchers over the years due to their complexity and biological activity. Organic chemists have made great efforts to investigate new unambiguous methodologies toward the synthesis of these ... -
TUNING THE SOLUBILITY, CELLULAR-UPTAKE AND ACTIVITY OF MICROTUBULE STABILIZING RUTHENIUM POLYPYRIDYL COMPLEXES
(2021-08-06)Many Ru(II) Polypyridyl Complexes (RPCs) are being investigated as they show potent cytotoxicity and acceptable toleration in animals. Some of these RPCs are thought to target DNA and/or mitochondria in cells. Recently, ... -
CONTINUOUSLY RENEWED COPPER ELECTRODE FOR AMPEROMETRIC MEASUREMENT OF CARBOHYDRATES
(2021-08-05)Currently the benchmark method for carbohydrate analysis in a variety of application areas involves anion exchange chromatography followed by electrochemical detection at a gold electrode. The gold electrode surfaces foul ... -
NEW STRATEGIES FOR HYDROSILYLATION OF PROPARGYL ALCOHOLS, OLEFIN POLYMERIZATION AND ON-CHIP ORGANIC SYNTHESIS
(2020-08-11)The research described in this dissertation is on three different projects namely i) design and synthesis of traceless hydrosilyl acetal-directed, exo-syn hydrosilylation of propargyl alcohols to produce α-hydroxy ... -
SYNTHESIS, STUDY, AND APPLICATIONS OF HIGHLY FLUORINATED COPPER PYRAZOLATE COMPLEXES OF SMALL ALKENE, ALKYNES AND CARBON MONOXIDE
(2020-07-17)Trinuclear copper pyrazolate complexes (copper trimers) function as excellent precursors to synthesize multinuclear complexes of copper. Using highly fluorinated pyrazolates as supporting ligands, we have successfully ...