Browsing Library by Author "MacDonnell, Frederick M."
Now showing items 21-24 of 24
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Ruthenium(II) Polypyridyl Complexes As Potential Anticancer Drugs: Synthesis, Characterization, Cell Permeability And Investigation Of Their Hypoxia-selectivity
Chen, Yanling (Chemistry & Biochemistry, 2013-03-20)Research on biological activity of ruthenium polypyridyl complexes (RPCs) continues to attract interest as these complexes have shown promising anti-cancer activity both in vitro and in vivo. The mononuclear RPC, ... -
Structure-Activity Relationships of Ruthenium(II) Polypyridyl Complexes with Redox-Active Intercalating Ligands: Correlation between Redox Activity, DNA Cleavage Capability and Cytotoxicity
Narh, Eugenia Soyo; 0000-0001-7511-7893 (2015-12-10)The investigation and development of transition metal complexes as cancer chemotherapeutics has gained a lot of interest in the past few decades and has become a promising area of research. Metal complexes of platinum and ... -
The Effects of the Stereochemistry of Ruthenium (II) Polypyridyl Complexes on Microtubules as Targets for Chemotherapy
Himawan, Radhiyah; 0000-0002-0338-2927 (2019-05-16)Ruthenium polypyridyl complexes (RPCs) are promising anticancer agents due to their robustness and tunability of their polypyridyl ligands. Their axial chirality generally allows for more selective binding to biological ... -
Towards Establishing The Mechanism Of DNA Cleavage By Redox-active Ruthenium(II) Polypyridyl Complexes
Griffith, Cynthia AnnIn earlier reports, it was established that ruthenium (II) polypyridyl complexes RPCs, [Ru(tatpp)]²⁺ (3²⁺) and [Ru(tatpp)Ru]⁴⁺ (4⁴⁺) show potent antitumor properties in vivo in nude mouse lung cancer models.² These RPC's ...