Browsing Library by Author "Kim, Young-Tae"
Now showing items 1-16 of 16
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Decreased Expression Of Microtubules In Confined Microenvironments Leads To A Reduced Effect Of Paclitaxel On Breast Cancer Cells
Sayles, Bailey (Biomedical Engineering, 2014-12)Despite the current medical options available to patients, cancer cells frequently remain after treatment and metastasize. This is particularly significant because secondary cancers account for 90% of cancer-related ... -
Design And Evaluation Of An Immnunoevasive Carbon Nanotube Sheet-collagen Composite Neural Electrode
Landrith, Ryan Andrew (Biomedical Engineering, 2014-12)Currently, long term neural interfacing is hindered by instability of the neural electrode-tissue interface. Many modes of electrode failure have been reported, though the tissue response to the foreign electrode body is ... -
Design, Fabrication And Evaluation Of A Novel Microfluidic Based In Vitro Cell Migration Assay
Dhavala, Sai Sirisha (Biomedical Engineering, 2014-09-17)Microfabrication and microfluidic devices have been recognized as potential platforms for cell-based and drug screening studies. Human glioblastoma multiforme (hGBM) cells migrate inside the central nervous system (CNS) ... -
Detection of Molecular Biomarkers involved in the Induction of EMT, migration and invasion, and drug resistance in breast cancer cells in 3D confinement
Hill, Tamara Nicole; 0000-0001-8129-3172 (2018-09-17)Standard-of-care regimes for cancer treatment have become more effective and sophisticated over the last decade due to research developments which facilitate specific targeting of treatments to certain cancers, and the ... -
DEVELOPMENT OF DIAGNOSTIC PLATFORMS USING SMART TECHNOLOGIES
Bellah, Md Motasim (University of Texas at Arlington Libraries, 2015-05)Mortality rate of cancer has not significantly dropped over the past six decades because there is no effective tool for early detection. Likewise, mortality rate of cardiovascular (CV) disease remains alarming due to the ... -
Development Of Microscope Stage Incubator For Long-term Monitoring Of Neuronal Cell Culture During Axotomy
Karthikeyan, Kailash (Biomedical Engineering, 2010-03-03)It is imperative to understand the patterns in regeneration of the central and peripheral nervous system after injury. This understanding would provide a fundamental cue towards molecules and other factors involved in ... -
Engineered Basal Lamina Equivalent - Fabrication And Biomedical Applications
Tamuly, Deepika (Biomedical Engineering, 2011-10-11)A novel technique based on the principle of solvent casting is developed to create uniform, ultrathin and stackable films of Collagen I/IV and ECMgel for use as Engineered Basal Lamina Equivalent. The mixture of these two ... -
Fabrication Of Small Diameter Vascular Graft Using Stacked Collagen Films
Shah, Sandeep (Biomedical Engineering, 2013-03-20)Collagen I have been widely used in the field of vascular tissue engineering. They are characterized better for their interaction at the cellular level but are often limited as vascular graft due to their weak mechanical ... -
INTUITIVE HUMAN ROBOT INTERFACES FOR UPPER LIMB PROSTHETICS
Yetkin, Oguz; 0000-0001-8602-2339 (2016-08-19)Modern robotic prosthetic devices for upper limb amputees promise to alleviate an important disability, but are underutilized due to the inability to properly control them. Specifically, the devices afford more degrees of ... -
Localized Treatment of Malignant Melanoma Using a Modified Cellulose-Based Hydrogel Loaded with Temozolomide with Increased Safety of Human Dermal Fibroblasts and the Mechanisms Behind the Effect
Wolf, Joseph; 0000-0002-2729-5430 (2021-08-30)Melanoma pathophysiology is highly varied, and the initial cause of tumorigenesis is still unknown, but it is likely a combination of both epigenetic and genetic means. Further, melanoma tumors have one of the highest ... -
Lung cancer growth forecasting and classification models by machine learning using a novel 2D co-culture high throughput device
Germain, Adam Adrien; 0000-0001-9942-4433 (2023-12-14)**Please note that the full text is embargoed until 02/01/2025** Co-culture devices have commonly been used during in vitro experimentation to create therapeutic testing devices for lung cancer that more closely mimic the ... -
Microfluidic Device For Determining Preferential Cell Migration Toward Extracellular Matrix Proteins
Hall, Neil (Biomedical Engineering, 2013-07-22)Extracellular matrix (ECM) proteins interact with cells in bodily microenvironments by influencing their essential cellular processes in growth, survival, migration and repair after injury. In this study, a novel microfluidic ... -
Microfluidic Systems For Studying Cell Motility
Vasudevan, Srikanth (Biomedical Engineering, 2010-11-01)It is very imperative to develop new in vitro platforms that can help in studying the complex interactions that occur between cell-Extracellular Matrix proteins and also during the process of cell migration in vivo. Such ... -
A Study On The Effect Of Mechanical Stretch And Aligned Scaffold Architecture On Morphology Of Rat Ventricular Cells
Kanakia, Shruti (Biomedical Engineering, 2009-09-16)Heart disease is one of the major causes of death in developing and industrialized countries. Myocardial infarction leads to remodeling of the left ventricle, which severely affects the pumping efficiency of the heart. In ... -
Substrate Stiffness Adjustable PDMS Device/array For Understanding Its Effect On Cell Growth, Differentiation And Migration
Bhuwania, Chetan (Biomedical Engineering, 2011-10-11)The mechanical properties of the cellular environment play an important role in the functioning of the cell. Cells attach to the extracellular matrix or other surrounding cells, thus sensing their mechanical properties and ... -
UNDERSTANDING KEY GENETIC MUTATIONS AND MOLECULAR ALTERATIONS ON INCREASING MIGRATION, VIABILITY, DRUG RESISTANCE OF MALIGNANT BRAIN TUMOR IN CONFINEMENT
Bui, Loan Thuy (2017-08-10)There are more than 120 types of primary brain and central nervous system tumors that affect people of all ages. Glioblastoma multiforme (GBM), for example, is the most frequent type of brain cancers and also among the ...