Browsing Library by Subject "Cytotoxicity"
Now showing items 1-5 of 5
-
INVESTIGATION OF THE CELLULAR UPTAKE AND CYTOTOXICITY OF RUTHENIUM(II) POLYPYRIDYL COMPLEXES AS A FUNCTION OF LIPOPHILICITY
(2022-05-17)Ru(II) polypyridyl complexes have been one of the focal points of investigation for inorganic anti-cancer drugs, as they are robust enough to remain chemically intact in vivo and many show potent cytotoxicty. In particular, ... -
RHENIUM(I) COMPLEXES OF TETRAAZATETRAPYRIDOPENTACENE (TATPP): SYNTHESIS, CHARACTERIZATION, REACTIVITY, ANTICANCER POTENTIAL AND LUMINESCENT PROBE TO DETERMINE CELLULAR LOCALIZATION
(2016-05-19)The ruthenium polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]4+ ([P]4+) and [(phen)2Ru(tatpp)]2+ ([MP]2+) are promising anti-tumor agents that arrest H358 NSCLC tumor growth in mouse tumor models and show cytotoxicity ... -
Structure-Activity Relationships of Ruthenium(II) Polypyridyl Complexes with Redox-Active Intercalating Ligands: Correlation between Redox Activity, DNA Cleavage Capability and Cytotoxicity
(2015-12-10)The investigation and development of transition metal complexes as cancer chemotherapeutics has gained a lot of interest in the past few decades and has become a promising area of research. Metal complexes of platinum and ... -
The Effects of the Stereochemistry of Ruthenium (II) Polypyridyl Complexes on Microtubules as Targets for Chemotherapy
(2019-05-16)Ruthenium polypyridyl complexes (RPCs) are promising anticancer agents due to their robustness and tunability of their polypyridyl ligands. Their axial chirality generally allows for more selective binding to biological ... -
TUNING THE SOLUBILITY, CELLULAR-UPTAKE AND ACTIVITY OF MICROTUBULE STABILIZING RUTHENIUM POLYPYRIDYL COMPLEXES
(2021-08-06)Many Ru(II) Polypyridyl Complexes (RPCs) are being investigated as they show potent cytotoxicity and acceptable toleration in animals. Some of these RPCs are thought to target DNA and/or mitochondria in cells. Recently, ...