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dc.contributor.author | Joshi, Manishkumar | en_US |
dc.date.accessioned | 2008-09-17T23:35:02Z | |
dc.date.available | 2008-09-17T23:35:02Z | |
dc.date.issued | 2008-09-17T23:35:02Z | |
dc.date.submitted | July 2008 | en_US |
dc.identifier.other | DISS-2179 | en_US |
dc.identifier.uri | http://hdl.handle.net/10106/1069 | |
dc.description.abstract | Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization method which is capable of transferring weakly bound host-guest noncovalent complexes from the solution phase to the gas phase. This capability makes ESI-MS an ideal tool for the
quantification of binding affinities of different host-guest noncovalent complexes.
There is a growing interest in using ESI-MS for chiral recognition studies. In thiswork ESI-MS was employed to investiga te the binding affinities for cinchona alkaloid chiral selectors binding N-blocked leucine enantiomers, as well as for macrocyclic
antibiotics binding a variety of derivatized and underivatized amino acids. The effect of multivalency on binding affinity was also evaluated. This ESI-MS method is very promising for the binding studies of different host-guest systems. Merits of this method are speed, sensitivity and low sample consumption. | en_US |
dc.description.sponsorship | Schug, Kevin A. | en_US |
dc.language.iso | EN | en_US |
dc.publisher | Chemistry & Biochemistry | en_US |
dc.title | Chiral Recognition And Binding Constant Determination In Monovalent And Bivalent Systems Using Electrospray Ionization Mass Spectrometry | en_US |
dc.type | M.S. | en_US |
dc.contributor.committeeChair | Schug, Kevin A. | en_US |
dc.degree.department | Chemistry & Biochemistry | en_US |
dc.degree.discipline | Chemistry & Biochemistry | en_US |
dc.degree.grantor | University of Texas at Arlington | en_US |
dc.degree.level | masters | en_US |
dc.degree.name | M.S. | en_US |
dc.identifier.externalLink | https://www.uta.edu/ra/real/editprofile.php?onlyview=1&pid=1407 | |
dc.identifier.externalLinkDescription | Link to Research Profiles | |
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