Browsing Theses and Dissertations(library) by Author "Foss, Frank W."
Now showing items 1-8 of 8
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ANTIBACTERIAL DRUG DESIGN AND DISCOVERY VIA VITAMIN B1 BIOSYNTHETIC PATHWAY
Shakar, Abu Afzal Mohammad (2016-08-15)Antibiotics play a vital role in fighting infectious disease caused by bacterial species. Antimicrobial resistance has been shown for every current antibiotic and poses a major health risk. To combat these growing threats ... -
DESIGN AND EVALUATION OF HMP KINASE ANALOGS AS THIAMINE PATHWAY INHIBITORS
Lopez, Diego A. (2016-08-15)Current bacterial chemotherapy faces an overwhelming reduction in efficacy due to an increase in bacterial resistance; resulting in a higher clinical demand for novel therapeutics and the investigation for their respective ... -
Design And Synthesis Of Flavin-based Organocatalysts For Biomimetic Aerobic Oxidation Reactions
Chen, Shuai (Chemistry & Biochemistry, 2014-03-12)Oxidation reactions are among the most costly and least selective transformations in synthetic chemistry. Catalytic methods that utilize O₂ as a terminal oxidant strive to reduce the inefficiency in this large area of ... -
DESIGN, SYNTHESIS AND APPLICATIONS OF BIOMIMETIC FLAVIN-BASED ORGANOCATALYSTS
Hossain, Mohammad Shawkat (University of Texas at Arlington Libraries, 2015-12)Oxidation reactions are one of the most important transformations in synthetic chemistry. Most commonly used oxidants are metal oxides, which are neither green nor selective towards multi-functional molecules. The efficiency ... -
Redox and Non-Redox Reactions Catalyzed by Biomimetic Flavin-based Organocatalysts and the Discovery of Selective Oxidation Methods for the Preparation of N-Heterocycles
Thapa, Pawan; 0000-0003-1608-5363 (2018-08-08)In nature, flavoproteins (FMN and FAD) are known to catalyze several chemical transformations which play a vital role in the growth, development, and survival of organisms. They are involved in one-electron and two-electron ... -
STUDIES TOWARDS THE TOTAL SYNTHESIS OF IMIDAZOLE-CONTAINING NATURAL PRODUCTS
Seal, Lawton Anthony II (2018-09-11)Nature has inspired man in all aspects of life, chemistry included. The first antibiotic ever discovered came from nature, and since then, chemists have been probing nature for insights to guide drug discovery and development. ... -
SYNTHESIS OF MODIFIED RIBOSE SPIN-LABEL
Chang, Ke-wei (2015-11-24)Transfer ribonucleic acids (tRNAs) from all organisms contain modified nucleosides, which are derived from four different nucleosides. Research has indicated that tRNA modifications affect translation and various metabolic ... -
Synthetic Strategies To Probe Enzymatic Activity: Investigation Of A Novel Oxygen-dependent Non-heme Diiron Monooxygenase (MiaE)
Corder, Andra Lynn (Chemistry & Biochemistry, 2014-09-17)Within the anticodon stem loop (ACSL) of tRNA, nucleoside modifications are frequently observed at position 34 (the wobble position) or position 37 (3' adjacent to the anticodon). For instance, nearly all eukaryotic and ...