Browsing Department of Biology by Author "Christensen, Shawn"
Now showing items 1-8 of 8
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A Biochemical Approach To Determine The Target Site Recognition Mechanism Of The R2 Retrotransposable Elements
Thompson, Blaine K. (Biology, 2011-07-14)Non-LTR Retrotransposons (NLRs) are selfish mobile genetic elements which parasitize the genomes of many organisms including humans. These elements transpose through an RNA intermediate and integrate directly into their ... -
The CCHC Motif In Non-LTR Retrotransposons Modulates RNA Associated Protein Conformational Changes
Jagdish, Athena (Biology, 2014-03-10)Non-LTR retrotransposons encode a conserved cysteine histidine motif of undetermined function. The spacing of the cysteines and histidine residues in the motif is CX₃CX₇HX4C. The site specific non-LTR retrotransposon R2Bm ... -
GLOBAL MAPPING OF PROTEIN-NUCLEIC ACID INTERACTION OF THE RLE LINE R2Bm
Dhamala, Santosh (2022-05-17)The R2 Long Interspersed Nucleotide Elements (LINEs) is a widely distributed site specific non-LTR retrotransposons that integrates exclusively into host genome’s 28s rRNA genes and replicate by a process called Target ... -
GLOBULAR DOMAIN STRUCTURE AND FUNCTION OF RESTRICTION-LIKE-ENDONUCLEASE BEARING LONG INTERSPERSED NUCLEOTIDE ELEMENTS
Mahbub, Mst Murshida (2017-08-09)Long Interspersed Nucleotide Elements (LINEs) are a major group of eukaryotic transposable elements that have profoundly influenced and sculpted eukaryotic genome structure and function. LINEs replicate within the host ... -
Insertion Mechanism of Long Interspersed Elements (LINEs) and the role of the Linker Domain
Pradhan, Monika (2018-08-27)Long Interspersed Elements (LINEs), also known as non-Long Terminal Repeat (non-LTR) retrotransposons are major group of transposable elements ubiquitous in eukaryotic genomes and are known to altogether influence the ... -
Integration Mechanism Of The Site Specific Non-LTR Retrotransposon, R2Bm
Hull, Christi Lynn (Biology, 2010-07-19)The focus of this thesis is the mechanistic study of non-LTR retrotransposon replication using the site specific transposon R2Bm. Non-LTR retrotransposons integrate into new chromosomal sites by copying their RNA back ... -
PROTEIN/NUCLEIC-ACID STRUCTURE AND SEQUENCE REQUIREMENTS FOR SPECIFYING SECOND-STRAND CLEAVAGE AND SECOND-STRAND SYNTHESIS DURING THE INTEGRATION OF THE SITE-SPECIFIC LINE R2Bm
Govindaraju, Aruna (2017-08-09)Long interspersed nucleotide elements (LINEs) are major drivers of genomic landscaping events in many eukaryotic genomes. LINEs encode a multifunctional protein that binds to their own mRNA, recognize and cleave target ... -
Targeting Of Site-specific Non-LTR Retrotransposons: Role Of Amino-terminal Domains
Shivram, Haridha (Biology, 2012-04-11)Restriction-like endonuclease (RLE) bearing non-LTR retrotransposons are site-specificelements that integrate into the genome through target primed reverse transcription (TPRT). RLE-bearing elements have been used as a ...