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EVOLUTIONARY AND BIOCHEMICAL CHARACTERIZATION OF EFFECTOR CASPASES
(2021-04-16)
Caspases are an ancient class of cysteine-dependent aspartate-specific proteases that control apoptosis, responsible for cell differentiation, and maintain cellular homeostasis in multicellular organisms. Dysregulation of ...
THE MECHANISM OF ENZYME STABILITY AND SPECIFICITY IN CASPASE-3
(2021-04-20)
The caspase family has been found as regulated proteins that play an important role in apoptosis and inflammation. Incorrect caspase regulation may cause serious diseases such as cancer. Knowing the mechanisms and evolution ...
Investigation of the Evolution and Structural Basis of Caspases: Insights into Conformational Dynamics, Stability and Allostery
(2023-05-01)
Caspases, a class of cysteinyl proteases, are well known for their roles in apoptosis or programmed cell death. However, at lower levels of activation in the body, they also play other non-apoptotic roles in cell proliferation, ...