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dc.contributor.author | Nguyen, Kytai Truong | |
dc.contributor.author | Patel, Ronak H. | |
dc.contributor.author | Patel, Nimet L. | |
dc.contributor.author | Kavuri, Venkaiah C. | |
dc.contributor.author | Liu, Hanli | |
dc.date.accessioned | 2014-07-31T20:53:18Z | |
dc.date.available | 2014-07-31T20:53:18Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Published in Journal of Biomedical Optics 17(4), 046003 (April 2012) | en_US |
dc.identifier.issn | 1083-3668 | |
dc.identifier.uri | http://hdl.handle.net/10106/24515 | |
dc.description | Copyright 2012 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. | en_US |
dc.description.abstract | The aim of this study was to develop and characterize multifunctional biodegradable and biocompatible
poly lactic-co-glycolic acid (PLGA) nanoparticles loaded with indocyanine green (ICG) as an optical-imaging contrast
agent for cancer imaging and as a photothermal therapy agent for cancer treatment. PLGA-ICG nanoparticles
(PIN) were synthesized with a particle diameter of 246 11 nm, a polydispersity index of 0.10 0.03, and ICG
loading efficiency of 48.75 5.48%. PIN were optically characterized with peak excitation and emission at 765
and 810 5 nm, a fluorescence lifetime of 0.30 0.01 ns, and peak absorbance at 780 nm. The cytocompatibility
study of PIN showed 85% cell viability till 1-mg∕ml concentration of PIN. Successful cellular uptake of ligand
conjugated PIN by prostate cancer cells (PC3) was also obtained. Both phantom-based and in vitro cell culture
results demonstrated that PIN (1) have the great potential to induce local hyperthermia (i.e., temperature increase
of 8 to 10°C) in tissue within 5 mm both in radius and in depth; (2) result in improved optical stability, excellent
biocompatibility with healthy cells, and a great targeting capability; (3) have the ability to serve as an image contrast
agent for deep-tissue imaging in diffuse optical tomography. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | SPIE | en_US |
dc.subject | Indocyanine green | en_US |
dc.subject | Biodegradable nanoparticles | en_US |
dc.subject | Optical imaging contrast | en_US |
dc.subject | Hyperthermia | en_US |
dc.subject | Diffuse optical imaging | en_US |
dc.title | Multifunctionality of indocyanine green-loaded biodegradable nanoparticles for enhanced optical imaging and hyperthermia intervention of cancer | en_US |
dc.type | Article | en_US |
dc.publisher.department | Department of Bioengineering, The University of Texas at Arlington | en_US |
dc.identifier.doi | 10.1http://dx.doi.org/117/1.JBO.17.4.046003 | |
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