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dc.contributor.author | Kribs, Christopher | |
dc.contributor.author | Chowell, Gerardo | |
dc.contributor.author | Castillo-Chavez, Carlos | |
dc.contributor.author | Fenimore, Paul W. | |
dc.contributor.author | Arriola, Leon | |
dc.contributor.author | Hyman, James M. | |
dc.date.accessioned | 2014-08-21T18:40:07Z | |
dc.date.available | 2014-08-21T18:40:07Z | |
dc.date.issued | 2004-07 | |
dc.identifier.citation | Published in Emerging Invectious Diseases 10(7):1258-1263, 2004 | en_US |
dc.identifier.issn | 1080-6059 | |
dc.identifier.issn | 1080-6040 | |
dc.identifier.uri | http://hdl.handle.net/10106/24551 | |
dc.description.abstract | Control of the 2002–2003 severe acute respiratory
syndrome (SARS) outbreak was based on rapid diagnosis
coupled with effective patient isolation. We used uncertainty
and sensitivity analysis of the basic reproductive number
R0 to assess the role that model parameters play in outbreak
control. The transmission rate and isolation effectiveness
have the largest fractional effect on R0. We estimated
the distribution of the reproductive number R0 under perfect
isolation conditions. The distribution lies in the interquartile
range 0.19–1.08, with a median of 0.49. Even though the
median of R0 is <1, we found that 25% of our R0 distribution
lies at R0 > 1, even with perfect isolation. This implies the
need to simultaneously apply more than one method of
control. | en_US |
dc.description.sponsorship | This research has been supported through the Center for
Nonlinear Studies at Los Alamos National Laboratory under
Department of Energy contract W-7405-ENG-36 and partially
supported by National Science Foundation, National Security
Agency, and Sloan Foundation grants to Carlos Castillo-Chavez. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Centers for Disease Control and Prevention | en_US |
dc.subject | Epidemic modeling | en_US |
dc.subject | Infectious disease | en_US |
dc.subject | SARS | en_US |
dc.title | Model parameters and outbreak control for SARS | en_US |
dc.type | Article | en_US |
dc.publisher.department | Mathematics Department, University of Texas at Arlington | |
dc.identifier.externalLink | http://wwwnc.cdc.gov/eid/article/10/7/03-0647_article | en_US |
dc.identifier.externalLinkDescription | The original publication is available at the journal homepage. | en_US |
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