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Dysregulated Calcium Signaling in Cardiomyocytes from Diabetic Atrial Fibrillation to Chemotherapy-Induced Cardiac Hypertrophy
(2020-08-13)
Ca2+ is a vital second messenger in cardiomyocytes and controls excitation-contraction coupling. It also regulates cell cycle, apoptosis, hypertrophy and downstream gene transcription in the heart remodeling. Calcium ...
Pathophysiology of Exercise Intolerance in Breast Cancer Survivors Treated with Anthracycline Chemotherapy
(2019-12-02)
Anthracyclines emerged as frontline breast cancer adjuvant therapy in the late 1960’s. Within half a decade of their clinical adoption, dose-limiting cardiotoxicity was recognized and cumulative dose limits were established ...