Browsing PhD Dissertations - DO NOT EDIT by Subject "Anthracycline"
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Dysregulated Calcium Signaling in Cardiomyocytes from Diabetic Atrial Fibrillation to Chemotherapy-Induced Cardiac Hypertrophy
(2020-08-13)Ca2+ is a vital second messenger in cardiomyocytes and controls excitation-contraction coupling. It also regulates cell cycle, apoptosis, hypertrophy and downstream gene transcription in the heart remodeling. Calcium ... -
Pathophysiology of Exercise Intolerance in Breast Cancer Survivors Treated with Anthracycline Chemotherapy
(2019-12-02)Anthracyclines emerged as frontline breast cancer adjuvant therapy in the late 1960’s. Within half a decade of their clinical adoption, dose-limiting cardiotoxicity was recognized and cumulative dose limits were established ...