Novel Techniques Of Fabricating Porous, Biodegradable Polymer Scaffolds For Sustained Drug Release

Abstract

Two types of porous scaffolds were made from biodegradable polymers and their drug release trends and rates were studied. In first method, the emulsion of PLLA in chloroform solution and PVA and acetaminophen in de-ionized water solution was made. The emulsion was blended with PLLA solution. The resultant emulsion was freeze vacuum dried. The drug release study was conducted in-vitro. In the second method, scaffolds had three layers. The top and bottom layers were made by blending PLLA solution with PVA solution. The middle layer was made by blending PLLA solution with a mixture of PVA and Acetaminophen in de-ionized water solution. The emulsion layers were freeze vacuum dried. The drug release study was conducted over a period of 25 days. Different combinations of PVA concentration and Blender speed were obtained. The cells were cultured and their presence into the scaffolds after 10 days was observed.