| dc.description.abstract | Nanotechnology has been widely used in the field of biomedical engineering. For example, nanoparticles have been employed for targeted drug delivery due to their retention effect, increased permeability, site-specific targeting, and avoiding phagocytosis as foreign materials. Moreover, nanotools, such as liposomes, Q-dots, dendrimers, micelles, and carbon nanotubes, have been developed for disease diagnosis and treatment. Generally, the application of nanotechnology can be categorized as follows: nanomedicine, tissue regeneration, biomarker/biosensors, nanorobots, and gene therapy. In the past four years, I have been focusing on developing nanotechnology for diagnosis and treatment of many diseases such as osteoarthritis, open wound, and infection. Based on the work I have done, I published two articles in peer reviewed journals and had one manuscript in submission. All the abovementioned works are summarized in the following chapters.
Chapter 1: Li S, Cong W, Hakamivala A, Huang Y, Borrelli J Jr, Tang L. Hyaluronic Acid-Based Optical Probe for the Diagnosis of Human Osteoarthritic Cartilage. Nanotheranostics 2018; 2(4):347-359.
Chapter 2: Chen W, Li S, Renick PJ, Yang S, Pandey N, Boutte C, Nguyen KT, Tang L, Dong H. Bacterial Acidity-Triggered Antimicrobial Activity of Self-assembling Peptide Nanofibers. Journal of Materials Chemistry B. 2019; 7(18):2915-2919.
Chapter 3: Li S, Zhou J, Huang Y, Roy J, Zhou N, Yum K, Sun X, Tang L. Injectable Click Chemistry-based Bioadhesives for Accelerated Wound Closure. Acta Biomaterialia. 2019 (under review).
Chapter 4: Li S, Vu H, Senkowsky J, Hu W, Tang L. A near infrared fluorescent pH indicator film for wound milieu pH monitoring. Experimental Dermatology. 2019. | |
