Ru(II) Polypyridyl Photosensitizers for Phototherapy
Abstract
**Please note that the full text is embargoed until 02/01/2025** This dissertation describes the design, synthesis, and photobiological
characterization of key target molecules that modify the 1) length of the IP-nT “PDT” ligand, 2) electronic nature of the bipyridine or phenanthroline type ancillary ligands, and 3) chirality of the coordination complex. The targets and subsequent studies will test the hypothesis that molecules with low-lying and long-lived 3ILCT states are responsible for this
unusually high photocytotoxic potency and seeks to further understand what structural features (aside from the IP-nT ligand) lead to more favorable photobiological properties.