Browsing Theses and Dissertations(library) by Subject "Caspases"
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Evolution of allostery and conformational dynamics of caspases involved in the extrinsic pathway of apoptosis
(2023-04-25)Caspases are a class of cysteine proteases that play a crucial role in programmed cell death (apoptosis). We complete an evolutionary picture of folding of caspases in the extrinsic pathway of apoptosis. The folding models ... -
EVOLUTIONARY AND BIOCHEMICAL CHARACTERIZATION OF EFFECTOR CASPASES
(2021-04-16)Caspases are an ancient class of cysteine-dependent aspartate-specific proteases that control apoptosis, responsible for cell differentiation, and maintain cellular homeostasis in multicellular organisms. Dysregulation of ... -
Investigation of the Evolution and Structural Basis of Caspases: Insights into Conformational Dynamics, Stability and Allostery
(2023-05-01)Caspases, a class of cysteinyl proteases, are well known for their roles in apoptosis or programmed cell death. However, at lower levels of activation in the body, they also play other non-apoptotic roles in cell proliferation, ...