Browsing Dissertations & Theses by Author "Roner, Michael"
Now showing items 1-11 of 11
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Analysis Of The Suppressive Effects By Reovirus On Rotavirus Replication During Co-infections
Kiesling-Barrager, Melody Lyn (Biology, 2010-11-01)Reovirus and rotavirus are both members of the Reoviridae family and commonly occur in children. Rotavirus induced diarrhea is one of the leading causes of death in children under the age of five worldwide. Identifying ... -
Anti-viral Activity Of Quillaja saponaria Molina Extracts Against HIV-1 And HIV-2
Sprayberry, Jennifer Lee (Biology, 2007-08-23)It has been well established that extracts from the bark of the South American tree Quillaja saponaria Molina have the capacity to stimulate strong immune responses against exogenous antigen when used as an adjuvant. ... -
Anti-viral Capacity Of Quillaja Saponaria Molina Extract Against Vaccinia And Herpes simplex Virus-1
Spinks, Matthew Sean (Biology, 2007-08-23)It is well known that Quillaja saponins have the ability to elicit a strong immune response when used as an adjuvant in an ISCOM matrix. However, to date, the antiviral capability of Quillaja saponins has not been documented. ... -
Cellular Targets Involved In Reovirus-induced Oncolysis Of RAs-transformed Cells
Chung, Jung Hwa (Biology, 2008-04-22)Reovirus is a ubiquitous virus with demonstrated oncolytic properties. In this study, we investigate the pathways which reovirus produces a lytic infection in SV-40 transformed WI-38 cells and the noncytocidal infection ... -
Characterization Of Anti-rotavirus Activities Of Saponin Extracts From Quillaja Saponaria
Tam, Ka Ian (Biology, 2010-11-01)Rotavirus is the leading cause of severe diarrhea disease in newborns and young children worldwide, estimated to be responsible for over 500,000 adolescent deaths mostly in developing countries each year. Rotavirus-related ... -
EFFICACY OF A SERIES OF ORGANOMETALLIC POLYMERS AS ANTI-CANCER AND ANTIVIRAL AGENTS
Miller, Lindsey Caitlin; 0000-0001-5438-5020 (2017-08-18)Organometallic compounds, particularly organotin compounds, have been known to possess biological activity for over 80 years. A variety of these compounds have demonstrated antimicrobial, anti-cancer, and antiviral activities. ... -
Efficacy Of A Series Of Organotin Polymers As Anticancer And Antiviral Drugs
Shahi, Kimberly Rae (Biology, 2008-04-22)Anticancer drugs have been shown to have antiviral abilities as well. The two types of diseases are similar in that they hold the cell in a continued growth phase. Therefore, if a drug has anticancer activity, it could ... -
Saponins As Agents Preventing Infection Caused By Waterborne Pathogens
Johnson, Alisa Moric (Biology, 2013-10-23)Waterborne diseases are the leading cause of deaths globally, estimated to result in more than 3.4 million deaths and approximately 4 billion cases of diarrhea annually according to the World Health Organization (WHO). The ... -
A Sticky Situation: Functional Responses Of Mast Cells To Acidic pH
Grose, Nicole Conaway (Biology, 2008-04-22)Precise regulation of extracellular pH is critical for proper function of many cellular activities. Minor fluctuations in pH can have profound effects on ion transport, receptor function, and cellular secretions. This work ... -
Use Of Reovirus Monoreassortants To Define Lysis Of Transfomed Cells
Mutsoli, Christine Nora (Biology, 2007-08-23)Reovirus is known to selectively destroy transformed cells while establishing a persistent infection in normal cells. For this study the transformed cell lines used were L929, WI-38 VA13 2RA, T1, N1, and MYC-3. Additionally, ... -
Use Of Temperature Sensitive Mutants To Map Reovirus Induced Oncolysis
Tam, Ka Ian (Biology, 2007-08-23)Reovirus is known to establish persistent infections in normal cells while selectively destroying transformed cells. Individual viruses from each of the ten groups of Reovirus is known to establish persistent infections ...