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THE MECHANISM OF ENZYME STABILITY AND SPECIFICITY IN CASPASE-3
(2021-04-20)
The caspase family has been found as regulated proteins that play an important role in apoptosis and inflammation. Incorrect caspase regulation may cause serious diseases such as cancer. Knowing the mechanisms and evolution ...
Investigation of the Evolution and Structural Basis of Caspases: Insights into Conformational Dynamics, Stability and Allostery
(2023-05-01)
Caspases, a class of cysteinyl proteases, are well known for their roles in apoptosis or programmed cell death. However, at lower levels of activation in the body, they also play other non-apoptotic roles in cell proliferation, ...
Evolution of allostery and conformational dynamics of caspases involved in the extrinsic pathway of apoptosis
(2023-04-25)
Caspases are a class of cysteine proteases that play a crucial role in programmed cell death (apoptosis). We complete an evolutionary picture of folding of caspases in the extrinsic pathway of apoptosis. The folding models ...