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dc.contributor.author | Wang, Xinlong | |
dc.contributor.author | Tian, Fenghua | |
dc.contributor.author | Soni, Sagar S. | |
dc.contributor.author | Gonzalez-Lima, F. | |
dc.contributor.author | Liu, Hanli | |
dc.date.accessioned | 2016-12-08T21:05:12Z | |
dc.date.available | 2016-12-08T21:05:12Z | |
dc.date.issued | 2016-08-03 | |
dc.identifier.citation | Published in Scientific Reports 6, Article number 30540: 1-10, 2016 | en_US |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10106/26294 | |
dc.description.abstract | Photobiomodulation, also known as low-level laser/light therapy (LLLT), refers to the use of red-tonear-infrared light to stimulate cellular functions for physiological or clinical benefits. The mechanism
of LLLT is assumed to rely on photon absorption by cytochrome c oxidase (CCO), the terminal enzyme
in the mitochondrial respiratory chain that catalyzes the reduction of oxygen for energy metabolism. In
this study, we used broadband near-infrared spectroscopy (NIRS) to measure the LLLT-induced changes
in CCO and hemoglobin concentrations in human forearms in vivo. Eleven healthy participants were
administered with 1064-nm laser and placebo treatments on their right forearms. The spectroscopic
data were analyzed and fitted with wavelength-dependent, modified Beer-Lambert Law. We found
that LLLT induced significant increases of CCO concentration (Δ[CCO]) and oxygenated hemoglobin
concentration (Δ[HbO]) on the treated site as the laser energy dose accumulated over time. A strong
linear interplay between Δ[CCO] and Δ[HbO] was observed for the first time during LLLT, indicating a
hemodynamic response of oxygen supply and blood volume closely coupled to the up-regulation of CCO
induced by photobiomodulation. These results demonstrate the tremendous potential of broadband
NIRS as a non-invasive, in vivo means to study mechanisms of photobiomodulation and perform
treatment evaluations of LLLT | |
dc.description.sponsorship | The authors acknowledge the support in part from the
University of Texas BRAIN Initiative Seed Funding (#362718). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Nature | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject | Broadband near-infrared spectroscopy (NIRS) | en_US |
dc.subject | Low-level laser/light therapy (LLLT) | en_US |
dc.subject | Cytochrome c oxidase | en_US |
dc.subject | Photobiomodulation | en_US |
dc.title | Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser | en_US |
dc.type | Article | en_US |
dc.publisher.department | Department of Bioengineering, The University of Texas at Arlington | en_US |
dc.identifier.externalLinkDescription | The original publication is available at the Article DOI | en_US |
dc.identifier.doi | DOI: 10.1038/srep30540 | |
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Except where otherwise noted, this item's license is described as Attribution 3.0 United States