Browsing Department of Chemistry and Biochemistry by Title
Now showing items 227-246 of 247
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Tailored Analytical Methods For Surveying Groundwater Quality In Areas Of Unconventional Drilling
Many questions have been raised over the environmental impact of unconventional drilling techniques, especially on the groundwater of the extraction area. Analytical approaches and methods specific to hydraulic fracturing ... -
TARGETED AND UNTARGETED CHROMATOGRAPHY-MASS SPECTROMETRY METHODS FOR ALCOHOLIC BEVERAGE ANALYSIS
(2021-08-16)There has been an increased interest in the “craft” alcohol industry in recent years. Contrary to larger corporations that focus on standardizing their recipes for mass production, these small, independent businesses can ... -
TEMPERATURE-PRESSURE PHASE DIAGRAMS OF METAL NITROGEN COMPOUNDS THROUGH DENSITY FUNCTIONAL THEORY COMPUTATIONS AND THERMODYNAMIC CALCULATIONS
(2021-12-20)The need for novel materials for new generations of applications is growing tremendously. One of many pathways to attain new materials is the route of high pressure synthesis. A particular active area in this high–pressure ... -
THE DETERMINATION OF WATER UTILIZING HEADSPACE GAS CHROMATOGRAPHY AND IONIC LIQUID STATIONARY PHASES
(2016-08-24)Water may be the most analyzed compound in the world. It is measured, monitored and controlled in many industries and most consumer products. The moisture is regulated in products intended for human/animal consumption (e.g. ... -
The Development Of The Catalytic Wittig Reaction
The formation of carbon-carbon double bonds with stereocontrol is of great importance to synthetic chemistry. The Wittig olefination involves the treatment of an aldehyde or ketone with a phosphonium ylide; yielding an ... -
The Effects of the Stereochemistry of Ruthenium (II) Polypyridyl Complexes on Microtubules as Targets for Chemotherapy
(2019-05-16)Ruthenium polypyridyl complexes (RPCs) are promising anticancer agents due to their robustness and tunability of their polypyridyl ligands. Their axial chirality generally allows for more selective binding to biological ... -
THE EVALUATION OF ENVIRONMENTAL CONTAMINANTS USING STATIC HEADSPACE GAS CHROMATOGRAPHY MASS SPECTROMETRY, VACUUM ULTRAVIOLET DETECTION
(2021-05-13)In analytical chemistry the term “headspace” refers to the vapor that forms above a sample (liquid or solid) in a closed container. Headspace (HS) sampling is the method to promote partition between volatile components ... -
The Role of HOTAIR in Skeletal Muscle Myogenesis
(2016-07-19)Skeletal muscle function is a vital requirement for an enriched healthy life. For years the molecular processes governing myogenesis and the development of skeletal muscle were primarily associated with proteins. In recent ... -
The roles of long noncoding RNAs in inflammation and immune responses
(2019-08-09)Inflammation is an immune response that protects the human body from infection, illness, or injury. The inflammatory response causes the activation of immune cells, such as leukocyte subsets (i.e., monocytes, macrophages, ... -
Thiol Dioxygenases: An Investigation Into The Mechanisms Of Cysteine Dioxygenase And 3-mercaptopropionic Acid Dioxygenase
(Chemistry & Biochemistry, 2015)Thiol dioxygenase (TDO) enzymes catalyze the molecular oxygen-dependent oxidation of sulfur containing amino acid derivatives. The loss of the ability to regulate thiols has been linked to a number of neurological diseases. ... -
Total Synthesis Of 2-aminoimidazole Alkaloids From Leucetta And Clathrina Sponges
(Chemistry & Biochemistry, 2010-07-19)Sponges of the major class, Calcarea can be found in nearly all marine habitats. Two Calcarea genera, Leucetta and Clathrina have found be rich with 2-aminoimidazole alkaloids. The first alkaloid of these groups was isolated ... -
Total Synthesis Of Cyclooroidin And Studies Towards Some Oroidin Dimers
(Chemistry & Biochemistry, 2010-07-19)This dissertation consists of two parts. The first part describes the synthesis of northern fragment of nagelamide R and the enantioselective total synthesis of cyclooroidin. The oroidin family of marine natural products ... -
Total Synthesis of Imidazole-Containing β-Carboline Alkaloids and Pyrrole-Imidazole Alkaloids
(2021-12-20)The first part in this dissertation focuses on the development of an enantioselective total synthesis of villagorgin A, from another natural product haploscleridamine. Haploscleridamine was targeted first as it was thought ... -
Total Synthesis Of Marine Derived Natural Products: Kealiiquinone And Ageliferin
(Chemistry & Biochemistry, 2014-03-17)An intramolecular Diels-Alder reaction of vinylimidazoles has been developed and applied towards the total synthesis of benzimidazole and tetrahydrobenzimidazole natural products, namely kealiiquinone and ageliferin. A ... -
Towards Establishing The Mechanism Of DNA Cleavage By Redox-active Ruthenium(II) Polypyridyl Complexes
In earlier reports, it was established that ruthenium (II) polypyridyl complexes RPCs, [Ru(tatpp)]²⁺ (3²⁺) and [Ru(tatpp)Ru]⁴⁺ (4⁴⁺) show potent antitumor properties in vivo in nude mouse lung cancer models.² These RPC's ... -
Toxicity study of CaCe₂S₄
(2017-08-07)In recent years, rare earth sulfides have received attention for their interesting thermoelectric and optical properties.1 They exhibit a fairly wide range of colors, which makes them promising candidates as pigments.2 ... -
TUNING THE SOLUBILITY, CELLULAR-UPTAKE AND ACTIVITY OF MICROTUBULE STABILIZING RUTHENIUM POLYPYRIDYL COMPLEXES
(2021-08-06)Many Ru(II) Polypyridyl Complexes (RPCs) are being investigated as they show potent cytotoxicity and acceptable toleration in animals. Some of these RPCs are thought to target DNA and/or mitochondria in cells. Recently, ... -
The Use Of Ionic Liquid Based Salts In Gas Chromatography And Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2010-07-19)This dissertation focuses on two uses for Room Temperature Ionic Liquids (RTILs). First, RTILs will be used to produce novel Gas Chromatographic (GC) stationary phases. The use of new phosphonium based RTIL GC columns ... -
The Use Of Liquid Chromatography And Subcritical Fluid Chromatography For Chiral Separations Using Macrocyclic Chiral Stationary Phases: Insights Into Mechanisms Of Retention And Chiral Discrimination
(Chemistry & Biochemistry, 2014-09-17)Enantiomeric separations are an essential component of pharmaceutical drug development, not only at the analytical scale, but also to separate usable quantities for further analysis. The field of asymmetric synthesis is ... -
The Use Of Supercritical Fluid Chromatography (sfc) And Liquid Chromatography (lc) For The Separation Of Pharmaceutical Products, Natural Products And Chiral Phosphoric And Sulfonic Acids
(Chemistry & Biochemistry, 2014-03-12)This dissertation focuses on two chromatographic techniques, supercritical fluid chromatography (SFC) and high performance liquid chromatography (HPLC). The goal of the SFC work is to describe the synthesis of new stationary ...