Department of Chemistry and Biochemistry
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Recent Submissions
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Thiol Dioxygenases: An Investigation Into The Mechanisms Of Cysteine Dioxygenase And 3-mercaptopropionic Acid Dioxygenase
Thiol dioxygenase (TDO) enzymes catalyze the molecular oxygen-dependent oxidation of sulfur containing amino acid derivatives. The loss of the ability to regulate thiols has been linked to a number of neurological diseases. ... -
Epigenetics Of HOXC13 Endocrine Regulation And Its Role In Gene Expression And Tumorigenesis
HOX genes are a subgroup of homeobox containing gene superfamily and have crucial roles in cell proliferation, cell differentiation, and embryonic development. HOXC13, one of 39 identified human HOX genes, is involved in ... -
Catalytic Hydro-liquefaction Of Lignite Coals Under Mild Conditions
A low-cost thermo-chemical process for the liquefaction of lignite coals is being developed at the University of Texas at Arlington (UTA). The coal-toliquids (CTL) project has focused of developing a liquefaction process ... -
Photo-driven One And Two-electron Processes Of Tetraazatetrapyridopentacene And Substituted Dipyridophenazine Ligands In The Presence Or Absence Of Zinc And Ruthenium Complexation
Herein, we report the interaction of light with Zn(II) and Ru(II) adducts of the polypyridal ligands tetraazatetrapyridopentacene (tatpp) and dipyridophenazine (dppz). For examples where Zn(II) is coordinated to tatpp and ... -
Controlled Hydrosilylations of Carbonyl Compounds and Computational Investigations of a Hydride Shuttle Mechanism for Alkene Hydrosilylation
(2015-11-30)Chapter 1 describes tandem dual hydrosilylations of α,β-unsaturated enals. Hydrosilylations of both carbonyl compounds and alkenes have been utilized to create chiral alcohols. Tandem dual hydrosilylations (TDH) of ... -
DETERMINATION OF TOTAL AND D-AMINO ACID CONTENT IN MICE BRAIN TISSUE BY ACHIRAL-CHIRAL HEART-CUTTING TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY: DIAGNOSTIC AND CLINICAL RELEVANCE AND A COMPARISON BETWEEN NON-PERFUSED AND PERFUSED TISSUE
(2015-11-24)A heart-cutting two dimensional liquid chromatographic method for the quantification of free amino acid enantiomers from mouse brain tissue is demonstrated. Evidence to support the occurrence of D-amino acids in significant ... -
Structure-Activity Relationships of Ruthenium(II) Polypyridyl Complexes with Redox-Active Intercalating Ligands: Correlation between Redox Activity, DNA Cleavage Capability and Cytotoxicity
(2015-12-10)The investigation and development of transition metal complexes as cancer chemotherapeutics has gained a lot of interest in the past few decades and has become a promising area of research. Metal complexes of platinum and ... -
New conductometric detection methods for sensitive ion chromatographic measurement of weak electrolytes
(2015-11-24)Since Suppressed conductometric anion chromatography (SCAC) was proposed in the mid-1970s, SCAC has become a widely used tool for the determination of anion species in aqueous samples. Its application ranges from trace ... -
SYNTHESIS OF MODIFIED RIBOSE SPIN-LABEL
(2015-11-24)Transfer ribonucleic acids (tRNAs) from all organisms contain modified nucleosides, which are derived from four different nucleosides. Research has indicated that tRNA modifications affect translation and various metabolic ... -
Concomitant Studies Of Two F420 Cofactor Dependent Enzymes: Binding Isotherms Of F420 Cofactor Dependent Glucose-6-phosphate Dehydrogenase And Kinetic Analysis Of F420H2: NADP+ Oxidoreductase Utilizing Isotope Effects Methods
F420 cofactor, a flavin analogue, is a unique two electron carrier that has been found in a number of microorganisms. This thesis focuses on two F420-dependent enzymes (F420-dependent glucose-6-phosphate dehydrogenase and ... -
Mechanistic And Kinetic Studies On F420H2: NADP+ Oxidoreductase From Archeoglobus fulgidus
F420H2: NADP+ Oxidoreductase (Fno) is an F420 cofactor dependent enzyme that catalyzes the reversible reduction of NADP+ to NADPH by transferring a hydride from the reduced F420 cofactor. F420 cofactor is an essential ... -
Solution Combustion Synthesis Of Oxide Semiconductors
The quest for stable and efficient photocatalytic materials beyond TiO2 and WO3 has over the years led to the development of new materials that possess varied interfacial energetics. This dissertation study focused on using ... -
Studies On Reductive Horner-Wadsworth-Emmons Olefination Using Mixed Silyl Acetals
Homologation of esters to α,β-unsaturated esters is a useful transformation in organic synthesis. We have developed a new approach for the Ir-catalyzed reductive Horner-Wadsworth-Emmons olefination of esters; a one-pot ... -
Light Driven Reduction Of Carbon Dioxide Via Ruthenium Polypyridyl Complexes In The Presence Of A Pyridinium Cocatalyst
The rapid increase in atmospheric carbon dioxide since the industrial revolution is now beginning to cause global climate changes which could adversely affect our planets ecosystem. Nonetheless, our ability to sustain the ... -
Cytotoxicty, Cellular Localization And Fluorescent Microscopy Of Malignant Cells Treated With Ruthenium (II) Complexes Of The Tetraazatetrapyridopentacene Ligand
The ruthenium (II) polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]4+, (P) and [(phen)2Ru(tatpp)]2+, (MP) are promising anticancer activity candidates due to their observed cytotoxic effect against multiple cancer cell ... -
Towards Establishing The Mechanism Of Dna Cleavage By Redox-active Ruthenium(II) Polypyridyl Complexes
In earlier reports, it was established that ruthenium (II) polypyridyl complexes RPCs, [Ru(tatpp)]²⁺ (3²⁺) and [Ru(tatpp)Ru]⁴⁺ (4⁴⁺) show potent antitumor properties in vivo in nude mouse lung cancer models.² These RPC's ... -
Redox Active Lipophilic Ruthenium Complexes As Potential Anti-cancer Drugs
The dinuclear ruthenium(II) polypyridyl complexes (RPCs) [(phen)2Ru(tatpp)Ru(phen)2][PF6]4 (P4+) and the monomeric [(phen)2Ru(tatpp)]Cl2 (MP2+) are promising candidates for anti-cancer drug development in terms of the ... -
Nickel (II) Pincer Complexes Supported By 2,6-Bis(3,5-ditolyl-2-pyrrolyl)Pyridine
Ni(II) pincer complexes are among the most important and useful compounds in homogeneous catalysis. Significant advancement has been made in this field in recent years. Many Ni(II) pincer complexes have been prepared and ... -
Biochemical, Kinetic And Spectroscopic Characterizations Of Non-heme Iron Oxygenase Enzymes
MiaE is a non-heme diiron enzyme which catalyzes the O2-dependent hydroxylation of selected tRNA-nucleotides as part of a multienzyme posttranscriptional hypermodification pathway. This tRNA-modifying enzyme is postulated ... -
Determination Of Nicotine And Its Metabolites Accumulated In Fish Tissue Using Quechers And Hydrophilic Interaction Liquid Chromatography And Tandem Mass Spectrometry
The quantitative determination of nicotine and its major metabolites (cotinine and anabasine) in fish tissue was performed using hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry. ...
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