Browsing Department of Chemistry and Biochemistry by Title
Now showing items 111-130 of 247
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Investigation of Computational Determination of Elastic Properties for Silicon Nitride and Silicon Carbonitride Materials
(2020-08-10)Silicon nitride and silicon carbonitride materials are versatile materials exhibiting useful properties at high temperatures and pressures. This study investigates the use of molecular dynamics simulations to determine ... -
Investigation of F420-dependent glucose-6-phosphate dehydrogenase variants using pH profiles and stopped-flow spectrometric ligand-binding methods
(2022-05-18)**Please note that the full text is embargoed until 5/17/2024** ABSTRACT: F420-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacteria tuberculosis, catalyzes a reaction the conversion of glucose-6-phosphate ... -
Investigation Of Redox-active Ruthenium(II) Polypyridyl Complexes As Potential Anti-cancer Drugs
(Chemistry & Biochemistry, 2009-09-16)Stereospecific binding of ruthenium metallointercalators with DNA is of particular interest because of the potential for improved targeting of specific sites in DNA. The present studies are focused on new metallointercalator, ... -
Investigation Of Ruthenium (II) Polypyridyl Dimers As Potential Chemotherapeutic Agents
(Chemistry & Biochemistry, 2007-08-23)The exploration of transition metal complexes as chemotherapeutic agents is still a relatively unexplored but promising area of research. Chapter 1 highlights the most successful anticancer drugs and potential drugs based ... -
INVESTIGATION OF THE CELLULAR UPTAKE AND CYTOTOXICITY OF RUTHENIUM(II) POLYPYRIDYL COMPLEXES AS A FUNCTION OF LIPOPHILICITY
(2022-05-17)Ru(II) polypyridyl complexes have been one of the focal points of investigation for inorganic anti-cancer drugs, as they are robust enough to remain chemically intact in vivo and many show potent cytotoxicty. In particular, ... -
Investigation Of The Suitability Of The Biscatecholborate Anion As A Reductive Quencher For Photoexcited Ruthenium Polyphyridyl Complexes
(Chemistry & Biochemistry, 2007-08-23)Ruthenium polypyridyl complexes [Ru(L-L)3]2+, (L-L = 1,10 - phenanthroline or 2,2'- bipyridine) which covalently linked to electron donor or acceptor units are frequently used in artificial photosystems because of their ... -
Investigations Of The Mechanism Of DNA Cleavage Using Ruthenium Polypyridyl Complexes
(Chemistry & Biochemistry, 2007-08-23)We have synthesized a ruthenium complex, [(phen)2Ru(tatpp)Ru(phen)2]4+ (P4+), which has been shown to undergo various redox and protonation steps to form different species that can be monitored by UV-Vis spectroscopy. In ... -
Ion Exchanger Based Ion Generation And Removal Devices. Behavior And Applications
(Chemistry & Biochemistry, 2012-04-11)Ion exchangers have many important applications. In Ion chromatography (IC), ion exchangers are used as stationary phase and used in some of the key components. The innovations that make the modern IC the most popular ... -
Ionic Liquids In Analytical Chemistry And Calix[4]arene Chemistry Of NOx Gases
(Chemistry & Biochemistry, 2011-03-03)Application of ionic liquids (ILs) in analytical chemistry can be numerous. The use of ILs in analytical techniques including gas chromatography (GC), electrospray ionization mass spectrometry (ESI-MS), capillary electrophoresis ... -
Ionic Liquids: Syntheses, Characterization And Applications In Analytical Chemistry
(Chemistry & Biochemistry, 2008-08-08)Multifunctional ionic liquids (esp. dicationic and dianionic) have been shown to have a greater range of physical properties than most traditional, singly charged ILs. In this work, 28 novel tricationic ILs with specific ... -
Ionization Competitors Extend The Linear Range Of Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2010-03-03)ESI-MS has proven its applicability in quantitative analysis for a wide range of analytes. Its effectiveness relies on achieving sensitivity and linear range, although the latter is known to be limited. ESI-MS response ... -
Leveraging propargylic frameworks in the total synthesis of natural products containing a 2-aminoimidazole
(2019-08-30)Our group is mainly interested in the total synthesis of marine sponge-derived 2-aminoimidazole-containing alkaloids. A new family of 2-aminoimidazole alkaloids, the Leucetta alkaloids, is a group of >60, 2-aminoimidazole ... -
Light Driven Reduction Of Carbon Dioxide Via Ruthenium Polypyridyl Complexes In The Presence Of A Pyridinium Cocatalyst
The rapid increase in atmospheric carbon dioxide since the industrial revolution is now beginning to cause global climate changes which could adversely affect our planets ecosystem. Nonetheless, our ability to sustain the ... -
LIQUID FLOW MEASUREMENT: FROM INLINE HYDROCEPHALUS SHUNT FLOW MONITOR TO FLOWMETRY IN THE NANOLITER/MINUTE SCALE
(2019-08-13)This dissertation primarily focuses on designing and developing novel sensing strategies and instruments for ultra-low liquid flow measurement. An inline thermal flow sensor based on a single common thermistor has been ... -
LnCrTeO6 (Ln= La, Pr, Nd) octahedral distortions and optical characterization
(2022-08-17)LnCrTeO6 (La, Pr, Nd) compounds are suspected to appear as vibrant blue-green colored materials. LnCrTeO6 (La, Pr, Nd) were synthesized to analyze the local coordination environments of Ln3+, Cr3+, and Te6+ cations. ... -
Long non-coding RNAs in inflammation, macrophage activation, and inflammatory human diseases
(2023-08-28)**Please note that the full text is embargoed until 08/01/2025** Inflammation and immune signaling is central to infection and diseases. Growing evidence suggests that along with protein coding genes, long non-coding RNAs ... -
Mass Spectrometry-based Biomolecular Recognition And Response Factor Investigations Using Electrospray Ionization
(Chemistry & Biochemistry, 2008-09-17)Integrins are transmembrane proteins found in almost all cells. They play vital roles in many biological processes, such as angiogenesis and signal transduction, through their interactions with different extracellular ... -
MECHANISM AND USE OF PAIRED ION ELECTROSPRAY IONIZATION (PIESI) IN HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (HPLC-MS) FOR SENSITIVE ANALYSIS OF ANIONIC COMPOUNDS
(2016-04-18)In recent years, the paired ion electrospray ionization (PIESI) technique has been emerged as a promising alternative to overcome the inherent low sensitivity of negative ESI-MS. The current research focused on the further ... -
Mechanistic And Kinetic Studies On F420H2: NADP+ Oxidoreductase From Archeoglobus fulgidus
F420H2: NADP+ Oxidoreductase (Fno) is an F420 cofactor dependent enzyme that catalyzes the reversible reduction of NADP+ to NADPH by transferring a hydride from the reduced F420 cofactor. F420 cofactor is an essential ... -
MECHANISTIC STUDIES OF F420-DEPENDENT ENZYMES BY KINETIC ANALYSIS
(2021-08-10)The focus of this research is to elucidate the catalytic mechanism of F420-dependent enzymes using F420-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacteria tuberculosis (Mtb) and F420H2:NADP+ Oxidoreductase ...