Browsing Department of Chemistry and Biochemistry by Title
Now showing items 43-62 of 247
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Crystalline SiCO: Implication On Structure And Thermochemistry Of Ternary Silicon Oxycarbide Ceramics
(Chemistry & Biochemistry, 2014-09-17)The need for innovative refractory materials - materials that can sustain extreme temperatures - has been constantly growing within the modern industries. Basic requirements for usage at ultra-high-temperatures have been ... -
Cytotoxicity Studies On Metallo-salens And Their Applications In Gene Delivery
(Chemistry & Biochemistry, 2009-09-16)Most of biological catalysts including nucleases are made of active metal centers. Metal complexes that are able to interact with DNA and RNA mimicking these natural nucleases will be valuable as therapeutic agents that ... -
Cytotoxicty, Cellular Localization And Fluorescent Microscopy Of Malignant Cells Treated With Ruthenium (II) Complexes Of The Tetraazatetrapyridopentacene Ligand
The ruthenium (II) polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]4+, (P) and [(phen)2Ru(tatpp)]2+, (MP) are promising anticancer activity candidates due to their observed cytotoxic effect against multiple cancer cell ... -
DERIVATIZATION OF SMALL ACIDS TO ENHANCE SENSITIVITY IN GAS CHROMATOGRAPHY MASS SPECTROMETRY AND GAS CHROMATOGRAPHY VACUUM ULTRAVIOLET SPECTROSCOPY
(2016-08-12)Disinfection by-products (DBPs) are a significant concern in drinking water quality. Haloacetic acids, which are generated from disinfection processes, are one of the major groups in disinfection by-products. Because they ... -
DESIGN AND EVALUATION OF HMP KINASE ANALOGS AS THIAMINE PATHWAY INHIBITORS
(2016-08-15)Current bacterial chemotherapy faces an overwhelming reduction in efficacy due to an increase in bacterial resistance; resulting in a higher clinical demand for novel therapeutics and the investigation for their respective ... -
Design And Synthesis Of A High Potential Ruthenium (II) Tetraazatetrapyridopentaphene Complex Capable Of Two-electron Reduction
(Chemistry & Biochemistry, 2010-03-03)We report the synthesis of a complex, [(phen)₂Ru(tatpph)Ru(phen)₂]⁴⁺ (Ph⁴⁺), which like its predecessor compound, [(phen)₂Ru(tatppc)Ru(phen)₂]⁴⁺ (Pc ⁴⁺), can undergo two sequential 1-electron photoreductions in MeCN in ... -
Design And Synthesis Of Flavin-based Organocatalysts For Biomimetic Aerobic Oxidation Reactions
(Chemistry & Biochemistry, 2014-03-12)Oxidation reactions are among the most costly and least selective transformations in synthetic chemistry. Catalytic methods that utilize O₂ as a terminal oxidant strive to reduce the inefficiency in this large area of ... -
Designing thermally stable ionic liquid stationary phases for gas chromatography and examining their structure-property relationships
(2018-11-30)Ionic liquids are popular in diverse scientific applications because of their unique physicochemical properties. The physicochemical properties of ionic liquids can be “tuned” by the modification of their structural moieties. ... -
Determination Of Nicotine And Its Metabolites Accumulated In Fish Tissue Using Quechers And Hydrophilic Interaction Liquid Chromatography And Tandem Mass Spectrometry
(Chemistry & Biochemistry, 2014-12)The quantitative determination of nicotine and its major metabolites (cotinine and anabasine) in fish tissue was performed using hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry. ... -
DETERMINATION OF THE KINETIC ROLES OF THE MEMBRANE IN THE CATALYSIS OF RASGEFS BY USING AN ENGINEERED MODEL PROTEIN
(2021-08-10)Ras guanine nucleotide exchange factors (RasGEFs), which include Son of Sevenless (SOS), Ras Guanine Nucleotide Releasing Protein (RasGRP), and Ras Guanine Nucleotide Releasing Factor (RasGRF), catalyze nucleotide exchange ... -
DETERMINATION OF TOTAL AND D-AMINO ACID CONTENT IN MICE BRAIN TISSUE BY ACHIRAL-CHIRAL HEART-CUTTING TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY: DIAGNOSTIC AND CLINICAL RELEVANCE AND A COMPARISON BETWEEN NON-PERFUSED AND PERFUSED TISSUE
(2015-11-24)A heart-cutting two dimensional liquid chromatographic method for the quantification of free amino acid enantiomers from mouse brain tissue is demonstrated. Evidence to support the occurrence of D-amino acids in significant ... -
Developing chemo-proteomics methods for tyrosine conjugation and studies of organometallic complexes of gold.
(2023-05-22)**Please note that the full text is embargoed until 05/14/2025** ABSTRACT: The incredible changes in MS instrumentation since the late 1980s with the advent of electrospray ionization (ESI) and matrix-assisted laser ... -
Development And Application Of New Mass Spectrometry-based Proteomics Technologies To Post-translational Modifications
(Chemistry & Biochemistry, 2009-09-16)Post-translational modifications (PTMs) represent one of the major cellular mechanisms to diversify the limited number of proteins coded by genome. They provide dynamic regulation of protein functions and the means to ... -
Development of Colorimetric and Fluorescent Antibiotic Biosensors and Synthesis of Drug-Related Biomimetic Molecules for Calcium Carbonate Polymorph Control and Stabilization
(2022-12-19)Polydiacetylene (PDA) polymers are conjugated macromolecules with desirable sensing properties. The presence of alternate double and triple bonds (en-yne subunits) generates electron delocalization in the PDA backbone, ... -
DEVELOPMENT OF HIGHLY POLAR STRUCTURALLY-TUNED IONIC LIQUIDS WITH UNIQUE SELECTIVITY FOR GAS CHROMATOGRAPHY
(2018-11-30)Ionic Liquids (ILs) are state-of-the-art fluids that have found broad application in separation science. Owing to their unique physicochemical properties such as low vapor pressure, high thermal stability, and high viscosity, ... -
DEVELOPMENT OF HPLC STATIONARY PHASES WITH UNIQUE SELECTIVITIES AND INTRODUCTION OF MOLECULAR ROTATIONAL RESONANCE SPECTROSCOPY IN GAS CHROMATOGRAPHY
(2020-11-23)This thesis contributes to advancing liquid and gas chromatography by introducing new stationary phases for HPLC and a new hyphenated GC technique. In the first section, new pH stable stationary phases based on geopolymers ... -
DEVELOPMENT OF INNOVATIVE THERANOSTIC PLATFORMS FOR BIOMEDICAL APPLICATIONS
(2019-08-12)Modern technologies have been successfully identifying patient’s disease-related genetic information and developing effective drugs continuously. The discovery of molecular biomarkers paves new roads for potential ... -
Development Of New Chiral Selectors For Liquid Chromatography And Their Performance Relative To Established Chiral Stationary Phases (CSPS)
(Chemistry & Biochemistry, 2010-03-03)HPLC with chiral stationary phases (CSPs) has proven to be the most widely applicable and versatile technique for enantiomeric separations. This dissertation discusses new research in three important areas of enantiomeric ... -
Development Of New Stationary Phases And Their Applications In High Performance Liquid Chromatography
(Chemistry & Biochemistry, 2013-10-22)High performance liquid chromatography (HPLC) has proven to be the most widely applicable and versatile technique in separation science. Hydrophilic interaction liquid chromatography (HILIC) has attracted considerable ... -
Development Of Paired Ion Electrospray Ionization Mass Spectrometry For Ultrasensitive Detection Of Anions
(Chemistry & Biochemistry, 2014-09-17)Mass spectrometry (MS) has emerged as an essential analytical technique over the last several decades. It is a widely applicable and powerful tool for determination and identification of different types of molecules. ...