Browsing Department of Chemistry and Biochemistry by Title
Now showing items 80-99 of 247
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ENANTIOSELECTIVE SYNTHESIS OF AN ANTICANCER RUTHENIUM POLYPYRIDYL COMPLEX (RPC) AND INFLUENCE OF CHIRAL SELECTIVITY ON DNA PHOTOCLEAVAGE
(2017-12-08)Ruthenium polypyridyl complexes (RPCs) represent a promising therapeiutic class of drugs for transition-metal based anticancer drug development. The complex [(phen)2Ru(tatpp)Ru(phen)2] (44+) is a RPC which has shown success ... -
ENE REACTIONS OF METHYLIDENE THIAZOLIDINES
(2021-06-03)This thesis describes the synthesis of seven new racemic molecules from methylidene thiazolidines reacting with two enophiles, N-phenylmaleimide and ethyl glyoxylate. The synthesis of these molecules was achieved through ... -
ENRICHMENT AND IDENTIFICATION OF DISULFIDE BONDED PEPTIDES BY TANDEM MASS SPECTROMETRY
(2017-08-09)Proteins are Comprised of different amino acids which can undergo various modifications known as post-translational modifications (PTMs). Amino acid’s side chains are the most common sites for the PTMs. Cysteine side chain ... -
EPIGENETIC MECHANISM OF REGULATION OF HOX GENES AND NEUROTRANSMITTERS VIA HORMONES AND LncRNA
(2017-08-02)Endocrine disrupting chemicals (EDCs) are classes of environmental contaminants whose exposure even at very low concentrations interfere with normal endocrine signaling and induce many adverse health effects including ... -
Epigenetics Of HOXC13 Endocrine Regulation And Its Role In Gene Expression And Tumorigenesis
(Chemistry & Biochemistry, 12-10-2012)HOX genes are a subgroup of homeobox containing gene superfamily and have crucial roles in cell proliferation, cell differentiation, and embryonic development. HOXC13, one of 39 identified human HOX genes, is involved in ... -
EPIMERIC PEPTIDES IN ALZHEIMER’S DISEASE: IMPLICATIONS FOR LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY AND IMMUNOTHERAPIES
(2023-05-19)Evidence has shown that the extracellular deposition of amyloid-beta (Aβ) peptide is a contributing factor of Alzheimer’s disease. Further, modifications to Aβ peptides may enhance the deposition of Aβ plaques and/or ... -
Estrogen Analysis By Liquid Chromatography - Mass Spectrometry
(Chemistry & Biochemistry, 2011-03-03)Estrogens are well known as female hormones associated with both health and disease. Although they have been reported as potential carcinogens, their use as therapy in the treatment of neurodegeneration has recently received ... -
EVALUATION OF ACTIVATED CARBON AS A COMMERCIAL DRUG DISPOSAL PRODUCT USING LIQUID CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY
(2015-11-18)At present, pharmaceuticals, synthetic organic compounds, and endocrine disrupting compounds are ubiquitous in our environment. These have been introduced by consumers and manufacturers directly and indirectly for decades. ... -
Examining Ruthenium Chromophores For The Photochemical Reduction Of CO₂To Methanol
(Chemistry & Biochemistry, 2014-03-12)Our consumption of energy for transportation and electricity has been growing as quickly as our population. As this demand for energy increases we increase our production of carbon dioxide by the burning of fossil fuels ... -
EXPEDITIOUS APPROACH TO 3,3’-BIS-SILYL BINOLS, BIPHENOLS, AND 3,3’-BIS-SILYL PHOSPHORAMIDITES ENABLED BY CATALYTIC C–H SILYLATION WITH A TRACELESS ACETAL DIRECTING GROUP
(2021-05-10)The research described in this dissertation is on two different projects namely i) Syntheses of 3,3’-bis functionalized BINOL and biphenol compounds, ii) Syntheses of 3,3’-bis silyl-BINOL-based phosphoramidites. The first ... -
EXPLORING FLEXIBLE CONFIGURATIONS OF A CUSTOM MULTIPATH LC –MS FOR SMALL MOLECULES AND PROTEIN ANALYSIS
(2017-08-07)There are diseases where both small molecules and proteins are found as disease indicators. In the usual analysis of small molecules, proteins are precipitated out during the sample preparation. In the small molecule ... -
FLUORINATED ALCOHOL INDUCED SUPRAMOLECULAR BIPBASIC SYSTEMS IN PROTEOMICS AND LIPIDOMICS
(2021-05-28)The Fluoroalcohol induced Supramolecular Biphasic (FAiS-BP) systems are composed of a supramolecular phase which is a highly concentrated mixture of a fluoroalcohol and an amphiphile, and a separate aqueous-rich phase. The ... -
FLUOROALCOHOL INDUCED SUPRAMOLECULAR BIPHASIC SYSTEMS OF ZWITTERIONIC SURFACTANTS, MIXED AMPHIPHILES, AND POLAR ORGANIC SOLVENTS IN PROTEOMICS AND ENVIRONMENTAL ANALYSIS
(2021-12-17)In this research, we have investigated several HFIP-induced biphasic systems of zwitterionic surfactants like CHAPS and DMMAPS and their mixed amphiphilic systems for the extraction, enrichment, and fractionation of mixture ... -
Fundamental And Applied Studies Of An Ambient Ionization Technique: Continuous Flow-extractive Desorption Electrospray Ionization - Mass Spectrometry
(Chemistry & Biochemistry, 2014-07-14)Continuous flow extractive desorption electrospray ionization (CF-EDESI) is a novel ambient ionization technique that was developed to help analyze samples from non-ESI-friendly solvents, manipulate protein charge states, ... -
FUNDAMENTAL STUDIES ON ULTRAFAST CHIRAL AND ACHIRAL SEPARATIONS IN LIQUID CHROMATOGRAPHY AND SUB/SUPERCRITICAL FLUID CHROMATOGRAPHY
(2017-05-03)This thesis is based on fundamental contributions in the field of ultrafast chiral and achiral separations using liquid and sub/supercritical fluid chromatography. The high efficiency sub-2 μm particles of narrow particle ... -
FUNDAMENTAL STUDIES ON ULTRAFAST SEPARATIONS AND DEVELOPMENT OF GEOPOLYMER BASED BASE-STABLE STATIONARY PHASE MEDIA
(2018-12-13)This thesis consists of two sections. In the first section fundamentals of ultrafast separations is discussed. Ultrafast chromatography is an emerging area of separation science due to its applicability in high-throughput ... -
F₄₂₀ cofactor dependent enzymes : kinetic, mechanistic and structural characterization of F₄₂₀-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacterium tuberculosis
(2017-08-02)F₄₂₀-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacterium tuberculosis (Mtb) is one of a few enzymes that utilize the unique F₄₂₀ cofactor for catalysis. FGD catalyzes the first committed step of the ... -
Gas Chromatography And Metal Analysis Of Produced Water Treated With A Household Commercial Filter
(2017-05-15)Unconventional oil and gas extraction activities, including hydraulic fracturing, are a collection of processes used to liberate significant quantities of natural gas and oil in the United States. Many extraction sites are ... -
Genetic Engineering Of Proteins For Biotechnology Applications
Heme b (protoporphyrin IX or protoheme) plays a major role in the structure and function in proteins such as myoglobin (Mb), hemoglobin (Hb), horseradish peroxidase (HRP), catalase, cytochrome P450 as well as catalase ... -
Genetically Modified Myoglobin As A Mimic For Heme Enzymes
(Chemistry & Biochemistry, 2013-07-22)This study addresses the mechanistic relationships between formation of reactive oxygen species (ROS) and their catalytic oxidation functions in oxygenation and peroxygenation reactions in heme enzymes. Even though both ...