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INTRACELLULAR BIOCHEMICAL TARGETS OF RUTHENIUM POLYPYRIDYL COMPLEXES IN MULTIPLE CANCER CELL MODELS
(2016-12-16)
The ruthenium (II) polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]4+, RPC4 and [(phen)2Ru(tatpp)]2+, RPC3 are promising anticancer candidates due to their observed cytotoxic effect against multiple cancer cell lines. ...
The Effects of the Stereochemistry of Ruthenium (II) Polypyridyl Complexes on Microtubules as Targets for Chemotherapy
(2019-05-16)
Ruthenium polypyridyl complexes (RPCs) are promising anticancer agents due to their robustness and tunability of their polypyridyl ligands. Their axial chirality generally allows for more selective binding to biological ...
TUNING THE SOLUBILITY, CELLULAR-UPTAKE AND ACTIVITY OF MICROTUBULE STABILIZING RUTHENIUM POLYPYRIDYL COMPLEXES
(2021-08-06)
Many Ru(II) Polypyridyl Complexes (RPCs) are being investigated as they show potent cytotoxicity and acceptable toleration in animals. Some of these RPCs are thought to target DNA and/or mitochondria in cells. Recently, ...