Browsing Dissertations & Theses by Issue Date
Now showing items 21-40 of 246
-
Novel Phenomena In Encapsulating Hydrocarbon Gases
(Chemistry & Biochemistry, 2008-04-22)The use of hydrophobic forces for entrapment of gases in water will be discussed. Natural hydrocarbons, haloalkanes, and anesthetic gases are hydrophobic in nature. In the course of this investigation water-soluble molecular ... -
Supramolecular Chemistry On Carbon Dioxide
(Chemistry, 2008-04-22)This dissertation describes approaches towards designs, syntheses, characterizations, and applications of supramolecular chemistry on carbon dioxide. Chapter 1 briefly overviews the field of supramolecular chemistry and ... -
Ring Closing Enyne Metathesis Of Imidazole Derivatives And Subsequent Diels-Alder Reaction
(Chemistry & Biochemistry, 2008-08-08)The work presented in this thesis describes the development of new synthetic routes to elaborate simple imidazole derivatives into complex imidazole molecules by the application of different sequential transformations. The ... -
Ral Interacting Protein (Ralbp1): Linking Glutathione Conjugate Transport To Oxidative Stress Defenses And Signaling Pathways
(Chemistry & Biochemistry, 2008-08-08)The glutathione-conjugate transporter protein DNP-SG ATPase was demonstrated to be identical to the independently cloned Ral-effector, Ralbp1. Glutathione-conjugate transport is linked to substrate-stimulated ATPase activity, ... -
Ralbp1 In Stress Resistance
(Chemistry & Biochemistry, 2008-08-08)Ralbp1 is a multi-specific transporter of glutathione conjugates as well as unconjugated amphiphilic toxins. Because glutathione conjugates are major metabolites of toxic lipid peroxidation products generated as a consequence ... -
Ionic Liquids: Syntheses, Characterization And Applications In Analytical Chemistry
(Chemistry & Biochemistry, 2008-08-08)Multifunctional ionic liquids (esp. dicationic and dianionic) have been shown to have a greater range of physical properties than most traditional, singly charged ILs. In this work, 28 novel tricationic ILs with specific ... -
Proteomic Strategies For Investigation Of Protein/ligand And Peptide/ligand Non-covalent Interactions By Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2008-08-08)Through universal proteomic methods and electrospray ionization-mass spectrometry (ESI-MS), multiple molecular recognition strategies were investigated as a prospective complementary tool for investigating protein-ligand ... -
Synthetic Studies And Biological Evaluation Of Imidazole-containing Marine Alkaloids
(Chemistry & Biochemistry, 2008-08-08)This dissertation discusses the synthetic methods towards and the preliminary biological studies of an unnamed, imidazole-containing alkaloid, derived from the marine species Oceanapia. This alkaloid was first discovered ... -
Mass Spectrometry-based Biomolecular Recognition And Response Factor Investigations Using Electrospray Ionization
(Chemistry & Biochemistry, 2008-09-17)Integrins are transmembrane proteins found in almost all cells. They play vital roles in many biological processes, such as angiogenesis and signal transduction, through their interactions with different extracellular ... -
Chiral Recognition And Binding Constant Determination In Monovalent And Bivalent Systems Using Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2008-09-17)Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization method which is capable of transferring weakly bound host-guest noncovalent complexes from the solution phase to the gas phase. This capability makes ... -
Plasma Surface Modifications For Biomedical And Electrical Applications
(Chemistry & Biochemistry, 2009-09-16)The focus of this work centers on molecular structuring of surfaces. The surface modifications were achieved using plasma polymerization technology, specifically variable duty cycle pulsed plasmas. The results obtained ... -
Mixed Lineage Leukemia Histone Methylases In Gene Expresion And Cancer
(Chemistry & Biochemistry, 2009-09-16)Histone methyl-transferases (HMTs) are key enzymes that post-translationally methylate nuclear histone proteins and play critical roles in gene expression, epigenetic regulation and diseases in eukaryotic organisms. Mixed ... -
Studies Of Enantiomeric Separations Using Capillary Electrophoresis
(Chemistry & Biochemistry, 2009-09-16)The focus of this thesis is on using state-of-the-art capillary electrophoresis (CE) in enantiomeric separations. Chapter 1 provides a brief introduction to enantiomeric separations using CE. Chapters 2 through 5 presents ... -
Development And Application Of New Mass Spectrometry-based Proteomics Technologies To Post-translational Modifications
(Chemistry & Biochemistry, 2009-09-16)Post-translational modifications (PTMs) represent one of the major cellular mechanisms to diversify the limited number of proteins coded by genome. They provide dynamic regulation of protein functions and the means to ... -
Synthesis And Study Of Fluorinated Thiophenes, Bithiophenes And Trithiophenes: Models For The Polymeric Material
(Chemistry & Biochemistry, 2009-09-16)3-Fluorothiophene is a small molecule and the known syntheses for this molecule are far from being straight forward and suffer from many drawbacks such as low yield, long synthetic procedures and the use of expensive or ... -
Investigation Of Redox-active Ruthenium(II) Polypyridyl Complexes As Potential Anti-cancer Drugs
(Chemistry & Biochemistry, 2009-09-16)Stereospecific binding of ruthenium metallointercalators with DNA is of particular interest because of the potential for improved targeting of specific sites in DNA. The present studies are focused on new metallointercalator, ... -
Cytotoxicity Studies On Metallo-salens And Their Applications In Gene Delivery
(Chemistry & Biochemistry, 2009-09-16)Most of biological catalysts including nucleases are made of active metal centers. Metal complexes that are able to interact with DNA and RNA mimicking these natural nucleases will be valuable as therapeutic agents that ... -
Design And Synthesis Of A High Potential Ruthenium (II) Tetraazatetrapyridopentaphene Complex Capable Of Two-electron Reduction
(Chemistry & Biochemistry, 2010-03-03)We report the synthesis of a complex, [(phen)₂Ru(tatpph)Ru(phen)₂]⁴⁺ (Ph⁴⁺), which like its predecessor compound, [(phen)₂Ru(tatppc)Ru(phen)₂]⁴⁺ (Pc ⁴⁺), can undergo two sequential 1-electron photoreductions in MeCN in ... -
Development Of New Chiral Selectors For Liquid Chromatography And Their Performance Relative To Established Chiral Stationary Phases (CSPS)
(Chemistry & Biochemistry, 2010-03-03)HPLC with chiral stationary phases (CSPs) has proven to be the most widely applicable and versatile technique for enantiomeric separations. This dissertation discusses new research in three important areas of enantiomeric ... -
Ionization Competitors Extend The Linear Range Of Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2010-03-03)ESI-MS has proven its applicability in quantitative analysis for a wide range of analytes. Its effectiveness relies on achieving sensitivity and linear range, although the latter is known to be limited. ESI-MS response ...