Browsing MS Theses - DO NOT EDIT by Title
Now showing items 24-43 of 73
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Effect Of Structure And Stereochemistry On Cytotoxicity Of Ruthenium Polypyridyl Complexes
(Chemistry & Biochemistry, 2007-08-23)Efforts to develop novel non-platinum, metal-based antitumor drugs have been pursued by many groups and ruthenium complexes have drawn a lot of attention as prospective transition metal-based antineoplastic agents. Recently, ... -
ENANTIOSELECTIVE SYNTHESIS OF AN ANTICANCER RUTHENIUM POLYPYRIDYL COMPLEX (RPC) AND INFLUENCE OF CHIRAL SELECTIVITY ON DNA PHOTOCLEAVAGE
(2017-12-08)Ruthenium polypyridyl complexes (RPCs) represent a promising therapeiutic class of drugs for transition-metal based anticancer drug development. The complex [(phen)2Ru(tatpp)Ru(phen)2] (44+) is a RPC which has shown success ... -
ENE REACTIONS OF METHYLIDENE THIAZOLIDINES
(2021-06-03)This thesis describes the synthesis of seven new racemic molecules from methylidene thiazolidines reacting with two enophiles, N-phenylmaleimide and ethyl glyoxylate. The synthesis of these molecules was achieved through ... -
ENRICHMENT AND IDENTIFICATION OF DISULFIDE BONDED PEPTIDES BY TANDEM MASS SPECTROMETRY
(2017-08-09)Proteins are Comprised of different amino acids which can undergo various modifications known as post-translational modifications (PTMs). Amino acid’s side chains are the most common sites for the PTMs. Cysteine side chain ... -
EVALUATION OF ACTIVATED CARBON AS A COMMERCIAL DRUG DISPOSAL PRODUCT USING LIQUID CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY
(2015-11-18)At present, pharmaceuticals, synthetic organic compounds, and endocrine disrupting compounds are ubiquitous in our environment. These have been introduced by consumers and manufacturers directly and indirectly for decades. ... -
Gas Chromatography And Metal Analysis Of Produced Water Treated With A Household Commercial Filter
(2017-05-15)Unconventional oil and gas extraction activities, including hydraulic fracturing, are a collection of processes used to liberate significant quantities of natural gas and oil in the United States. Many extraction sites are ... -
Headspace-Solid Phase Micro Extraction – Gas Chromatography – Mass Spectrometry (HS-SPME-GC-MS) Analysis for Oak Barrel Flavor Compounds in Whiskey
(2021-12-13)This study presents a method to simultaneously detect both fault compounds and oak barrel flavor compounds in whiskey using headspace-solid phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS). A major ... -
Identification of acidic residues in proteins by selective chemical labeling and tandem mass spectrometry
(2023-08-15)**Please note that the full text is embargoed until 08/01/2025** Proteins play important role in carrying out a wide range of cellular activities. They are subjected to various post-translational modifications (PTMs) by ... -
INCREASED HYDRIDE TRANSFER RATES WITHIN T09A MUTANT OF F420:H2 NADP+ OXIDOREDUCTASE
(2016-05-18)F420:H2 NADP+ oxidoreductase (Fno) is an F420 dependent enzyme found in methanogens and sulfate reducing archaea. Fno catalyzes the reversible reduction of NADP+ to NADPH through the transfer of a hydride involving F420 ... -
Increasing Lipophilicity Of Redox Active Ruthenium Complexes As A Means To Enhance Cytotoxicity And Reduce Animal Toxicity
(Chemistry & Biochemistry, 2013-03-20)The dinuclear and monomeric ruthenium(II) polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]Cl4 (P) and monomer [(phen)2Ru(tatpp)]Cl2 (MP) are promising candidates for anticancer drug development in terms of the observed ... -
Investigation of Computational Determination of Elastic Properties for Silicon Nitride and Silicon Carbonitride Materials
(2020-08-10)Silicon nitride and silicon carbonitride materials are versatile materials exhibiting useful properties at high temperatures and pressures. This study investigates the use of molecular dynamics simulations to determine ... -
Investigation of F420-dependent glucose-6-phosphate dehydrogenase variants using pH profiles and stopped-flow spectrometric ligand-binding methods
(2022-05-18)F420-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacteria tuberculosis, catalyzes a reaction the conversion of glucose-6-phosphate (G6P) to 6-phosphogluconolactone using the oxidized F420 cofactor, which is ... -
INVESTIGATION OF THE CELLULAR UPTAKE AND CYTOTOXICITY OF RUTHENIUM(II) POLYPYRIDYL COMPLEXES AS A FUNCTION OF LIPOPHILICITY
(2022-05-17)Ru(II) polypyridyl complexes have been one of the focal points of investigation for inorganic anti-cancer drugs, as they are robust enough to remain chemically intact in vivo and many show potent cytotoxicty. In particular, ... -
Investigation Of The Suitability Of The Biscatecholborate Anion As A Reductive Quencher For Photoexcited Ruthenium Polyphyridyl Complexes
(Chemistry & Biochemistry, 2007-08-23)Ruthenium polypyridyl complexes [Ru(L-L)3]2+, (L-L = 1,10 - phenanthroline or 2,2'- bipyridine) which covalently linked to electron donor or acceptor units are frequently used in artificial photosystems because of their ... -
Investigations Of The Mechanism Of DNA Cleavage Using Ruthenium Polypyridyl Complexes
(Chemistry & Biochemistry, 2007-08-23)We have synthesized a ruthenium complex, [(phen)2Ru(tatpp)Ru(phen)2]4+ (P4+), which has been shown to undergo various redox and protonation steps to form different species that can be monitored by UV-Vis spectroscopy. In ... -
Ionic Liquids: Syntheses, Characterization And Applications In Analytical Chemistry
(Chemistry & Biochemistry, 2008-08-08)Multifunctional ionic liquids (esp. dicationic and dianionic) have been shown to have a greater range of physical properties than most traditional, singly charged ILs. In this work, 28 novel tricationic ILs with specific ... -
Ionization Competitors Extend The Linear Range Of Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2010-03-03)ESI-MS has proven its applicability in quantitative analysis for a wide range of analytes. Its effectiveness relies on achieving sensitivity and linear range, although the latter is known to be limited. ESI-MS response ... -
Light Driven Reduction Of Carbon Dioxide Via Ruthenium Polypyridyl Complexes In The Presence Of A Pyridinium Cocatalyst
The rapid increase in atmospheric carbon dioxide since the industrial revolution is now beginning to cause global climate changes which could adversely affect our planets ecosystem. Nonetheless, our ability to sustain the ... -
LnCrTeO6 (Ln= La, Pr, Nd) octahedral distortions and optical characterization
(2022-08-17)LnCrTeO6 (La, Pr, Nd) compounds are suspected to appear as vibrant blue-green colored materials. LnCrTeO6 (La, Pr, Nd) were synthesized to analyze the local coordination environments of Ln3+, Cr3+, and Te6+ cations. ... -
Method development for qualification and quantification of cannabinoids and terpenes in extracts by Gas chromatography-mass spectrometry
(2016-07-19)Cannabinoids are a class of chemical compounds that act on cannabinoid receptors in cells. These receptors have different kinds of ligands, including endocannabinoids (produced in the body by humans and animals), ...