Browsing MS Theses - DO NOT EDIT by Title
Now showing items 51-70 of 73
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Probing Inter-Subunit Communication of F₄₂₀ NADP Oxidoreductase: A Kinetic Analysis
(2019-05-20)F₄₂₀-dependent enzymes are important in a number of organisms, which play vital roles in methane production, NADPH regulation, nucleic acid biosynthesis, folate biosynthesis and carbon cycling. Until our recent publications ... -
Proteomic Strategies For Investigation Of Protein/ligand And Peptide/ligand Non-covalent Interactions By Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2008-08-08)Through universal proteomic methods and electrospray ionization-mass spectrometry (ESI-MS), multiple molecular recognition strategies were investigated as a prospective complementary tool for investigating protein-ligand ... -
Reactive Atmosphere Pyrolysis(RAP) of Silicon Carbo Nitride (SiCN)
(2023-08-17)Polymer Derived Ceramics (PDCs) are synthesized by converting liquid polymer precursors into ceramics through controlled pyrolysis. This study focuses on silicon carbonitride (SiCN) ceramics obtained from Ceraset Polysilazane ... -
Ring Closing Enyne Metathesis Of Imidazole Derivatives And Subsequent Diels-Alder Reaction
(Chemistry & Biochemistry, 2008-08-08)The work presented in this thesis describes the development of new synthetic routes to elaborate simple imidazole derivatives into complex imidazole molecules by the application of different sequential transformations. The ... -
Ruthenium(II) Polypyridyl Complexes As Potential Anticancer Drugs: Synthesis, Characterization, Cell Permeability And Localization
(Chemistry & Biochemistry, 2013-07-22)Research on biological activities of ruthenium polypyridyl complexes (RPCs) continues to attract interest as these complexes have shown promising anticancer activity both in vitro and in vivo.¹⁻³ The mononuclear ... -
Ruthenium(II) Polypyridyl Complexes As Potential Anticancer Drugs: Synthesis, Characterization, Cell Permeability And Investigation Of Their Hypoxia-selectivity
(Chemistry & Biochemistry, 2013-03-20)Research on biological activity of ruthenium polypyridyl complexes (RPCs) continues to attract interest as these complexes have shown promising anti-cancer activity both in vitro and in vivo. The mononuclear RPC, ... -
Solid State Light Source Based Analytical Measurement Systems For Atmospheric Particles
(Chemistry & Biochemistry, 2012-04-11)Solid-state light sources such as light-emitting diodes, use a solid semiconductor block instead of a conventional heated filament or discharge source. Such light sources are preferred in analytical instrumentation because ... -
Structure-Activity Relationships of Ruthenium(II) Polypyridyl Complexes with Redox-Active Intercalating Ligands: Correlation between Redox Activity, DNA Cleavage Capability and Cytotoxicity
(2015-12-10)The investigation and development of transition metal complexes as cancer chemotherapeutics has gained a lot of interest in the past few decades and has become a promising area of research. Metal complexes of platinum and ... -
Studies Of Enantiomeric Separations Using Capillary Electrophoresis
(Chemistry & Biochemistry, 2009-09-16)The focus of this thesis is on using state-of-the-art capillary electrophoresis (CE) in enantiomeric separations. Chapter 1 provides a brief introduction to enantiomeric separations using CE. Chapters 2 through 5 presents ... -
STUDIES ON ENANTIOSELECTIVE DESYMMETRIZING ALKYNE HYDROSILYLATION
(2021-08-12)This research focuses on the design and synthesis of enantioselective desymmetrizing α-hydrosilylation of propargyl alcohols to provide α-hydroxy (E)-vinylsilanes. Transition metal-catalyzed, regio-and stereoselective ... -
Studies On Reductive Horner-Wadsworth-Emmons Olefination Using Mixed Silyl Acetals
Homologation of esters to α,β-unsaturated esters is a useful transformation in organic synthesis. We have developed a new approach for the Ir-catalyzed reductive Horner-Wadsworth-Emmons olefination of esters; a one-pot ... -
Studies Towards Bioactive Imidazoles
(Chemistry & Biochemistry, 2008-04-22)The work presented in this thesis focuses on the development of an enantioselective and practical route form the total synthesis of villagorgin via haplosleridamine imidazole alkaloid containing β- carboline moiety by ... -
Supercharging and Multiple Reaction Monitoring Optimization of High Molecular Weight Intact Proteins using Triple Quadrupole Mass Spectrometry
(2019-07-17)Various supercharging agents, such as meta-nitrobenzyl alcohol, dimethyl sulfoxide, trifluoroethanol (TFE), and sulfolane were tested in different concentrations to study the effects of supercharging agents on the charge ... -
Supramolecular Chemistry On Carbon Dioxide
(Chemistry, 2008-04-22)This dissertation describes approaches towards designs, syntheses, characterizations, and applications of supramolecular chemistry on carbon dioxide. Chapter 1 briefly overviews the field of supramolecular chemistry and ... -
Surface Functionalization Of Polymer Substrates And Nanoparticles Via Pulsed Plasma Polymerization Process
(Chemistry & Biochemistry, 2007-08-23)This thesis investigates the RF plasma polymerizations of chlorinated saturated linear monomer 1,1,1-trichloroethane and the dicarboxylic citraconic acid. It utilizes a variable duty cycle plasma technique to provide film ... -
Synthesis of modified polydiacetylene (PDA) polymers for the detection of infective species
(2019-08-09)Polydiacetylene (PDAs) polymers are receiving more attention as biosensors due to their ability to change absorption and fluorescence properties upon sensing various chemical and physical changes in the environment. In ... -
SYNTHESIS OF MODIFIED RIBOSE SPIN-LABEL
(2015-11-24)Transfer ribonucleic acids (tRNAs) from all organisms contain modified nucleosides, which are derived from four different nucleosides. Research has indicated that tRNA modifications affect translation and various metabolic ... -
The Effects of the Stereochemistry of Ruthenium (II) Polypyridyl Complexes on Microtubules as Targets for Chemotherapy
(2019-05-16)Ruthenium polypyridyl complexes (RPCs) are promising anticancer agents due to their robustness and tunability of their polypyridyl ligands. Their axial chirality generally allows for more selective binding to biological ... -
The Role of HOTAIR in Skeletal Muscle Myogenesis
(2016-07-19)Skeletal muscle function is a vital requirement for an enriched healthy life. For years the molecular processes governing myogenesis and the development of skeletal muscle were primarily associated with proteins. In recent ... -
Towards Establishing The Mechanism Of DNA Cleavage By Redox-active Ruthenium(II) Polypyridyl Complexes
In earlier reports, it was established that ruthenium (II) polypyridyl complexes RPCs, [Ru(tatpp)]²⁺ (3²⁺) and [Ru(tatpp)Ru]⁴⁺ (4⁴⁺) show potent antitumor properties in vivo in nude mouse lung cancer models.² These RPC's ...