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Method development for qualification and quantification of cannabinoids and terpenes in extracts by Gas chromatography-mass spectrometry
(2016-07-19)
Cannabinoids are a class of chemical compounds that act on cannabinoid receptors in cells. These receptors have different kinds of ligands, including endocannabinoids (produced in the body by humans and animals), ...
ANTIBACTERIAL DRUG DESIGN AND DISCOVERY VIA VITAMIN B1 BIOSYNTHETIC PATHWAY
(2016-08-15)
Antibiotics play a vital role in fighting infectious disease caused by bacterial species. Antimicrobial resistance has been shown for every current antibiotic and poses a major health risk. To combat these growing threats ...
The Role of HOTAIR in Skeletal Muscle Myogenesis
(2016-07-19)
Skeletal muscle function is a vital requirement for an enriched healthy life. For years the molecular processes governing myogenesis and the development of skeletal muscle were primarily associated with proteins. In recent ...
DERIVATIZATION OF SMALL ACIDS TO ENHANCE SENSITIVITY IN GAS CHROMATOGRAPHY MASS SPECTROMETRY AND GAS CHROMATOGRAPHY VACUUM ULTRAVIOLET SPECTROSCOPY
(2016-08-12)
Disinfection by-products (DBPs) are a significant concern in drinking water quality. Haloacetic acids, which are generated from disinfection processes, are one of the major groups in disinfection by-products. Because they ...
INCREASED HYDRIDE TRANSFER RATES WITHIN T09A MUTANT OF F420:H2 NADP+ OXIDOREDUCTASE
(2016-05-18)
F420:H2 NADP+ oxidoreductase (Fno) is an F420 dependent enzyme found in methanogens and sulfate reducing archaea. Fno catalyzes the reversible reduction of NADP+ to NADPH through the transfer of a hydride involving F420 ...
ENANTIOSELECTIVE SYNTHESIS OF AN ANTICANCER RUTHENIUM POLYPYRIDYL COMPLEX (RPC) AND INFLUENCE OF CHIRAL SELECTIVITY ON DNA PHOTOCLEAVAGE
(2017-12-08)
Ruthenium polypyridyl complexes (RPCs) represent a promising therapeiutic class of drugs for transition-metal based anticancer drug development. The complex [(phen)2Ru(tatpp)Ru(phen)2] (44+) is a RPC which has shown success ...
Supercharging and Multiple Reaction Monitoring Optimization of High Molecular Weight Intact Proteins using Triple Quadrupole Mass Spectrometry
(2019-07-17)
Various supercharging agents, such as meta-nitrobenzyl alcohol, dimethyl sulfoxide, trifluoroethanol (TFE), and sulfolane were tested in different concentrations to study the effects of supercharging agents on the charge ...
3,5-Bis(3,5-bis(trifluoromethyl)phenyl)pyrazolyl complexes of Coinage Metals
(2018-05-16)
Pyrazoles are an important class of five membered heterocyclic compounds consisting of two nitrogen atoms. Pyrazolate anions serve as useful ligands in coordination chemistry. When fluorinated substituents are attached to ...
Probing Inter-Subunit Communication of F₄₂₀ NADP Oxidoreductase: A Kinetic Analysis
(2019-05-20)
F₄₂₀-dependent enzymes are important in a number of organisms, which play vital roles in methane production, NADPH regulation, nucleic acid biosynthesis, folate biosynthesis and carbon cycling. Until our recent publications ...
The Effects of the Stereochemistry of Ruthenium (II) Polypyridyl Complexes on Microtubules as Targets for Chemotherapy
(2019-05-16)
Ruthenium polypyridyl complexes (RPCs) are promising anticancer agents due to their robustness and tunability of their polypyridyl ligands. Their axial chirality generally allows for more selective binding to biological ...