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Structure Modeling and Property Calculations of Amorphous Materials
(2019-05-16)
The demand in discovery of novel materials for a seemingly infinite list of applications is growing year by year. Even though it’s not uncommon to find the application for the material after its discovery upon experimentally ...
SYNTHESIS AND REACTIVITY OF π-CONJUGATED TRIAZENES
(2019-05-02)
The triazene functional group has found numerous applications in organic and medicinal chemistry, with several important chemotherapeutic drugs containing this functionality. In spite of this, the reactivity of π-conjugated ...
SYHTHESIS AND OPTICAL PROPERTIES OF RARE EARTH SULFIDES AND OXYSULFIDES
(2019-07-08)
Ternary and quaternary rare earth chalcogenides have gained prominence in recent years, especially because of their wide array of crystal structures and interesting physical properties attributed to the presence of f-electrons ...
The roles of long noncoding RNAs in inflammation and immune responses
(2019-08-09)
Inflammation is an immune response that protects the human body from infection, illness, or injury. The inflammatory response causes the activation of immune cells, such as leukocyte subsets (i.e., monocytes, macrophages, ...
Leveraging propargylic frameworks in the total synthesis of natural products containing a 2-aminoimidazole
(2019-08-30)
Our group is mainly interested in the total synthesis of marine sponge-derived 2-aminoimidazole-containing alkaloids. A new family of 2-aminoimidazole alkaloids, the Leucetta alkaloids, is a group of >60, 2-aminoimidazole ...
LIQUID FLOW MEASUREMENT: FROM INLINE HYDROCEPHALUS SHUNT FLOW MONITOR TO FLOWMETRY IN THE NANOLITER/MINUTE SCALE
(2019-08-13)
This dissertation primarily focuses on designing and developing novel sensing strategies and instruments for ultra-low liquid flow measurement.
An inline thermal flow sensor based on a single common thermistor has been ...
Improved sample preparation method for LC-MS/MS based cellular proteomics and co-immunoprecipitation cross-linking proteomics study of Toll-like receptor 4
(2019-08-02)
Mass spectrometry-based methods are now widely practiced in large-scale proteomics studies. Unfortunately, sample loss in proteomics hinders complex analysis in proteomics, and immune precipitation (IP) mass spectrometry-based ...
MECHANISTIC STUDY OF THE INHIBITION OF RHO GTPASE-MEDIATED METASTASIS
(2019-01-04)
The Ras superfamily of small GTPases are monomeric proteins that bind guanine nucleotides, and regulate many cellular signaling pathways. They function as molecular switches by shuttling between active GTP-bound and inactive ...
DEVELOPMENT OF INNOVATIVE THERANOSTIC PLATFORMS FOR BIOMEDICAL APPLICATIONS
(2019-08-12)
Modern technologies have been successfully identifying patient’s disease-related genetic information and developing effective drugs continuously. The discovery of molecular biomarkers paves new roads for potential ...
Catalytic C-C silylation Reactions
(2019-08-08)
In my doctoral studies, the research is mainly focused on developing highly regio- and chemoselective C–C silylation of cyclopropanol derivatives with a hydrosilyl acetal directing group. This approach involves use of a ...