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Stimuli-Responsive Peptide Self-Assembly for Therapeutic Delivery
(2022-08-16)
Peptide self-assembly offers an effective method to generate supramolecular
nanomaterials with much higher stability than traditional monomeric peptides. The materials
exhibit well-organized hierarchical structures and ...
Probing Short-Range Structural Distortion of Stereochemically Active Lone Pairs in Extended Solid-State Materials
(2022-12-20)
The structural and electronic effects of the lone pairs play an important role in magnetic, photocatalytic, and semiconducting behaviors of materials. Investigating the role of stereochemically active ns2 lone pairs derived ...
Development of Colorimetric and Fluorescent Antibiotic Biosensors and Synthesis of Drug-Related Biomimetic Molecules for Calcium Carbonate Polymorph Control and Stabilization
(2022-12-19)
Polydiacetylene (PDA) polymers are conjugated macromolecules with desirable sensing
properties. The presence of alternate double and triple bonds (en-yne subunits)
generates electron delocalization in the PDA backbone, ...
Synthetic studies on oxidative dearomatization reactions and applications in synthesis of the KB343 core structure, and investigation of bioactive thiazolidines
(2022-08-16)
Natural products have inspired researchers over the years due to their complexity and biological activity. Organic chemists have made great efforts to investigate new unambiguous methodologies toward the synthesis of these ...
Synthesis and Function of Ion-Selective Single-Molecule Fluorescent Imaging Molecules and Materials
(2022-05-18)
Neutrinos are fermion subatomic particles that interact only by weak subatomic forces—making them almost impossible to detect. However, they can be produced in specific radioactive decay reactions, such as beta decay.
We ...
SYNTHESIS OF ALLYLIC SYNTHONS AND APPLICATION OF PYRROLE THIOCARBOXYLIC ACIDS IN THE SYNTHESIS OF PYRROLE-IMIDAZOLE ALKALOIDS
(2022-05-17)
**Please note that the full text is embargoed until 5/16/2024** ABSTRACT: The first part of this dissertation describes the synthesis of allylic compounds from terminal alkenes without the use of any catalysts or oxidants. ...
Computational materials chemistry: from polymer precursors to ceramics and high-pressure materials
(2022-08-17)
With advances in computing power, the field of computational chemistry has flourished. Using current computational resources, atomistic simulations of billion atoms and trillions of atoms have been performed. Computational ...
SELF-ASSEMBLING PEPTIDES: FROM FUNDAMENTAL DESIGN TO THERAPEUTIC APPLICATIONS
(2022-08-16)
Supramolecular peptide-based biomaterials have attracted much attention from researchers in various science and engineering fields because of the ease of synthesis and precise control over structures and physicochemical ...
Molecular dynamics simulations of the adenylate kinase enzyme and its mutant states
(2022-12-19)
Adenylate kinase (AK) is a small, monomeric enzyme present across all domains of life. It is responsible for maintaining homeostasis of an intracellular adenylate pool and catalyzes a reversible transfer of the phosphoryl ...
AQUEOUS-BASED ASSOCIATED SOLVENTS FOR PROTEIN AND PEPTIDE FRACTIONATION AND PROTEIN PURIFICATION
(2022-01-03)
The focus of this dissertation is studying capabilities of a novel two-phase system in enhancing protein identification in the whole-cell proteomics studies. In this document, two types of biphasic systems have been used ...