Browsing PhD Dissertations - DO NOT EDIT by Title
Now showing items 15-34 of 113
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DESIGN, DEVELOPMENT, AND VALIDATION OF A NOVEL OPTICAL IMAGING DEVICE FOR BIOMEDICAL APPLICATIONS
(2019-07-31)Fluorescence and luminescence imaging are two promising optical techniques for diagnosing a variety of critical pathologies in vivo, including wound healing, inflammation, and vascular diseases. Despite this, there is a ... -
Designing and advancing contrast agents for ultrasound-switchable fluorescence imaging
(2021-12-09)Fluorescence imaging is a remarkable tool for molecular targeting and multicolor imaging, but it suffers from poor resolution in centimeters-deep tissues. The recently developed ultrasound-switchable fluorescence (USF) ... -
Detection of Molecular Biomarkers involved in the Induction of EMT, migration and invasion, and drug resistance in breast cancer cells in 3D confinement
(2018-09-17)Standard-of-care regimes for cancer treatment have become more effective and sophisticated over the last decade due to research developments which facilitate specific targeting of treatments to certain cancers, and the ... -
DEVELOPMENT AND INVESTIGATION OF FLUORESCENCE IMAGING PROBES
(2019-09-03)Fluorescence imaging has attracted much attention due to high sensitivity, spatial and temporal resolution, and fast acquisition time, for imaging biomolecular processes and for diagnosis of diseases such as cancer in early ... -
Development Of A Broadband Multi-channel NIRS System For Quantifying Absolute Concentrations Of Hemoglobin Derivatives And Reduced Scattering Coefficients
(Biomedical Engineering, 2008-08-08)Near infrared spectroscopy (NIRS) has been widely applied to investigate hemoglobin oxygenations of muscles, brain and breast tumors. Steady state reflectance techniques developed previously have been restricted to ... -
Development of Algorithms to Analyze Electrogastrography (EGG) for Neonatal Gastrointestinal Development and Electroencephalography (EEG) for Effects of LED-based Pre-frontal Light Stimulation
(2022-05-17)Algorithm development, and biological signal processing are the key components for new applications of successful medical diagnosis that can provide physiological and functional information to better understand human ... -
DEVELOPMENT OF AN IN VITRO TBI MODELS AND VALIDATION OF NANODELIVERY FOR RESTORATION OF DISRUPTED BRAIN ENDOTHELIUM
(2019-09-06)Blast-induced traumatic brain injury (bTBI) is a serious concern among military personnel and their families. Although the mechanisms responsible for disruption to the brain are not well understood, the development of ... -
Development Of Atlas-guided Diffuse Optical Tomography To Investigate Age-dependent Human Cognitive Functions Under Risk Decision Making
To better understand the age effect on neural correlates under risk decision-making stimulations, studies using advanced neuroimaging with a sufficient statistical power are desired. Diffuse optical tomography (DOT) of ... -
Development of medical devices for diagnosing cartilage injury and metastatic cancers
(2019-08-07)My research focused on applying biomedical engineering techniques to diagnose different diseases and conditions. The results of these work led to one published paper and two submitted manuscripts which are summarized in ... -
Development of medical devices for osteoarthritis diagnosis, antimicrobial, wound closure, and wound pH milieu monitoring
(2019-12-10)Nanotechnology has been widely used in the field of biomedical engineering. For example, nanoparticles have been employed for targeted drug delivery due to their retention effect, increased permeability, site-specific ... -
Development of Mussel Inspired Nanocomposite Adhesives for Biomedical Applications
Popular bioadhesives, such as fibrin, cyanoacrylate and albumin–glutaraldehyde-based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, ... -
Development Of Non-invasive Methods For Imaging Inflammatory Response
Persistent inflammatory cell reactions are responsible for the pathogenesis of a variety of inflammatory diseases. Although many non-invasive imaging methods have been used in the clinics to monitor the extent of inflammatory ... -
Development Of Orchestrated Stem Cell-based Regeneration (OSCeR) -strategies To Recruit And Differentiate Autologous Stem Cells For Tissue Regeneration
(Biomedical Engineering, 2011-03-03)Stem cell therapy has shown great promise in curing diseases. However, clinical application of stem cell therapy is often hindered by the lack of reliable sources and convenient methods to recover stem cells. Our laboratory ... -
Development of Particle Platforms for Delivery of Angiogenic Reagents to Treat Peripheral Arterial Diseases
(2019-01-11)Peripheral arterial disease (PAD) is a disease that one or several peripheral arteries are narrowed or blocked. PAD is an emerging disease that cost annually 10-20 billions of US dollars for health care in America. PAD ... -
Development Of SERS Nanoprobes For Multiplexed And Multi-modality Molecular Diagnosis Of Cancer
(Biomedical Engineering, 2014-03-10)Importance of cancer diagnosis and staging through molecular biomarker detection is evident in the increasing number of molecular biomarkers being discovered that are associated with specific cancers types with their role ... -
Development Of Trans-rectal Ultrasound (TRUS) Coupled Diffuse Optical Tomography (DOT) For Prostate Cancer Imaging
(Biomedical Engineering, 2014-09-17)Prostate cancer is one of the leading causes among cancer deaths in men in the United States. A minimally invasive real time searching tool for cancer need to be developed, which can enhance the odds of cancer detection; ... -
Diffuse Optical Tomography To Study The Ischemic Stroke In Rat Models
(Biomedical Engineering, 05-06-2013)Stroke, including ischemic stroke and hemorrhagic stroke, is the major leading cause of death in the United States. More than 80 percent of stroke patients are diagnosed with ischemic stroke, which usually results from ... -
Electrophysiological, Hemodynamic, and Metabolic Effects of Transcranial Photobiomodulation (tPBM) on Topographical and Physiological Connectivity in the Human Brain
(2022-08-17)Transcranial photobiomodulation (tPBM) targets the human brain with near-infrared (NIR) light and is shown to affect human cognitive performance and neural electrophysiological activity as well as concentration changes of ... -
Engineering Elastic and Functional Electrospun Nano-Fibers for Potential Heart Repair
(2022-08-17)In the United States and around the world, cardiovascular disease (CVD) has been one of the main causes of death since 1921, responsible for approximately 1 in 4 deaths domestically. Myocardial infarction (MI), or commonly ... -
Engineering Enzymatic Pathways in the Gut Microbiome to Control Dietary Isoflavone Metabolism
(2022-05-17)**Please note that the full text is embargoed until 5/17/2024** ABSTRACT: Observing how plasmids persist within the gut can help us understand how newly introduced genes are transmitted within the gut microbiome. I sought ...