Browsing PhD Dissertations - DO NOT EDIT by Title
Now showing items 32-51 of 113
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Electrophysiological, Hemodynamic, and Metabolic Effects of Transcranial Photobiomodulation (tPBM) on Topographical and Physiological Connectivity in the Human Brain
(2022-08-17)Transcranial photobiomodulation (tPBM) targets the human brain with near-infrared (NIR) light and is shown to affect human cognitive performance and neural electrophysiological activity as well as concentration changes of ... -
Engineering Elastic and Functional Electrospun Nano-Fibers for Potential Heart Repair
(2022-08-17)In the United States and around the world, cardiovascular disease (CVD) has been one of the main causes of death since 1921, responsible for approximately 1 in 4 deaths domestically. Myocardial infarction (MI), or commonly ... -
Engineering Enzymatic Pathways in the Gut Microbiome to Control Dietary Isoflavone Metabolism
(2022-05-17)**Please note that the full text is embargoed until 5/17/2024** ABSTRACT: Observing how plasmids persist within the gut can help us understand how newly introduced genes are transmitted within the gut microbiome. I sought ... -
Enhanced Endothelialization On Surface Modified Poly(L-lactic Acid)
(Biomedical Engineering, 2010-07-19)Current synthetic vascular grafts and polymer-coated drug-eluting stents (DES) have certain limitations, such as thrombosis and restenosis due to the incomplete recovery of vascular endothelial cells on their luminal sides. ... -
Establishing The Method Of Dual-tensor For Tract Based Analysis (DTTA) And Investigating Human Brain Developmental Connectome With Diffusion MRI
(Biomedical Engineering, 2014-07-14)Diffusion MRI (dMRI) has the unique ability of studying white matter fiber structure in the human brain in-vivo. The trajectory of the white matter fibers inside the brain can be mapped using the tractography techniques ... -
Establishment And Characterization Of An Animal Model Of Distraction Spinal Cord Injury
(Biomedical Engineering, 05-17-2013)Scoliosis corrective surgery requires the application of multidirectional stress forces to the spinal cord, including those of distraction, in addition to the application of fixation rods for correction of the curved spine ... -
Evaluation And Use Of Regenerative Multi Electrode Interfaces In Peripheral Nerves
(Biomedical Engineering, 2014-09-17)Peripheral nerves offer unique accessibility to the innate motor and sensory pathways that can be interfaced with high degree of selectivity for intuitive and bidirectional control of advanced upper extremity prosthetic ... -
EVALUATION OF A PERSONAL MOBILE TRAINER SYSTEM DESIGNED FOR FACILITATING EXERCISE THERAPY FOR TRAUMATIC BRAIN INJURY PATIENTS
(2021-08-16)There are no effective pharmacological agents that can prevent or treat post-TBI cognitive deterioration. Previous research has shown that exercise can be an effective means of enhancing the patients condition with mild ... -
Functional Studies of the Human Telomerase Holoenzyme
(2016-09-13)Telomeres are the DNA structures that cap the ends of linear chromosomes. In humans, telomeres are composed of the hexameric repeats TTAGGG. The reverse transcriptase, telomerase maintains the telomeres by adding the TTAGGG ... -
IMPACT OF MUSCULAR FATIGUE AND ITS MODULATION USING TRANSCRANIAL PHOTOBIOMODULATION (tPBM) ON THE HUMAN BRAIN MEASURED BY FUNCTIONAL NEAR-INFRARED SPECTROSCOPY (fNIRS)
(2020-07-22)When performing exercise, the brain must register and simultaneously integrate input from feedforward (i.e., central command) and feedback (e.g., exercise pressor reflex) neural mechanisms to make appropriate cardiovascular ... -
In vivo ultrasound-switchable fluorescence imaging and its applications
(2020-08-17)The conventional fluorescence imaging has limited spatial resolution in centimeters-deep tissue because of the tissue’s high scattering property. Ultrasound-switchable fluorescence (USF) imaging, a new imaging technique, ... -
INTUITIVE HUMAN ROBOT INTERFACES FOR UPPER LIMB PROSTHETICS
(2016-08-19)Modern robotic prosthetic devices for upper limb amputees promise to alleviate an important disability, but are underutilized due to the inability to properly control them. Specifically, the devices afford more degrees of ... -
Investigation Of Breast Tumor Hemodynamics By Near Infrared Spectroscopy: Applications To Cancer Therapy Monitoring
(Biomedical Engineering, 2007-08-23)Hyperoxic gas interventions using carbogen (95% O2 and 5% CO2) or oxygen has been tried to increase the tumor oxygenation since it will enhance the therapeutic effects on the tumors. Others in the laboratory had previously ... -
INVESTIGATION OF FUNCTIONAL CONNECTIVITY AND NEUROVASCULAR COUPLING IN DIFFERENT VIGILANCE / BREATH-HOLD STATES OF THE BRAIN FROM SIMULTANEOUS EEG-fNIRS MEASUREMENTS
(2019-07-10)Functional connectivity and neurovascular coupling are important phenomena that occur in the brain. Functional connectivity is the study of functional brain networks and their characteristics. While neurovascular coupling ... -
Investigation Of Neural Correlates Between Perception Of Pain And Hemodynamic Response Measured In The Pre-frontal Cortex Using Functional Near Infra-red Spectroscopy
(Biomedical Engineering, 2011-10-11)Perception of pain is multi-dimensional, comprising three major psychological dimensions: sensory-discriminative, motivational-affective and cognitive-evaluative. This dissertation study investigates the cognitive evaluation ... -
An Investigation Of The Effect Of Obstructive Sleep Apnea On Cerebral Hemodynamics In Relation With Systemic Hemodynamics
Obstructive Sleep Apnea (OSA) is a major sleep disorder affecting approximately 18 million adults in the US. Recent studies have observed cognitive impairments and brain structural changes in OSA subjects where these ... -
Investigations Into Causes Of Failure Of Regenerative Peripheral Nerve Interfaces
All highly selective methods of neural interfacing for mental control of a robotic prosthesis tested to date have exhibited high rates of failure over time. Regenerative peripheral nerve interfaces (RPNIs) may offer the ... -
Kinetics Analyses Of Interactions Between Oncogenic And Tumor Suppressor Proteins By Quantitative High Resolution Microscopy Methods
(Biomedical Engineering, 2013-07-22)DAB2IP is correlated to the risk of aggressive prostate cancer and loss of DAB2IP not only leads to epithelial-to-mesenchymal transition (EMT), but also makes cells radioresistant. These observations support the notion ... -
Localized Treatment of Malignant Melanoma Using a Modified Cellulose-Based Hydrogel Loaded with Temozolomide with Increased Safety of Human Dermal Fibroblasts and the Mechanisms Behind the Effect
(2021-08-30)Melanoma pathophysiology is highly varied, and the initial cause of tumorigenesis is still unknown, but it is likely a combination of both epigenetic and genetic means. Further, melanoma tumors have one of the highest ... -
Long Gap Peripheral Nerve Reconstruction Using Decellularized Nerve Grafts
Peripheral nerve injuries that arise as a result of trauma, tumor excision or birth can adversely affect the quality of patient life, leading to lifelong disabilities in some cases. Autologous nerve grafts are the clinical ...