Browsing PhD Dissertations - DO NOT EDIT by Title
Now showing items 40-59 of 113
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Functional Studies of the Human Telomerase Holoenzyme
(2016-09-13)Telomeres are the DNA structures that cap the ends of linear chromosomes. In humans, telomeres are composed of the hexameric repeats TTAGGG. The reverse transcriptase, telomerase maintains the telomeres by adding the TTAGGG ... -
IMPACT OF MUSCULAR FATIGUE AND ITS MODULATION USING TRANSCRANIAL PHOTOBIOMODULATION (tPBM) ON THE HUMAN BRAIN MEASURED BY FUNCTIONAL NEAR-INFRARED SPECTROSCOPY (fNIRS)
(2020-07-22)When performing exercise, the brain must register and simultaneously integrate input from feedforward (i.e., central command) and feedback (e.g., exercise pressor reflex) neural mechanisms to make appropriate cardiovascular ... -
In vivo ultrasound-switchable fluorescence imaging and its applications
(2020-08-17)The conventional fluorescence imaging has limited spatial resolution in centimeters-deep tissue because of the tissue’s high scattering property. Ultrasound-switchable fluorescence (USF) imaging, a new imaging technique, ... -
INTUITIVE HUMAN ROBOT INTERFACES FOR UPPER LIMB PROSTHETICS
(2016-08-19)Modern robotic prosthetic devices for upper limb amputees promise to alleviate an important disability, but are underutilized due to the inability to properly control them. Specifically, the devices afford more degrees of ... -
Investigation Of Breast Tumor Hemodynamics By Near Infrared Spectroscopy: Applications To Cancer Therapy Monitoring
(Biomedical Engineering, 2007-08-23)Hyperoxic gas interventions using carbogen (95% O2 and 5% CO2) or oxygen has been tried to increase the tumor oxygenation since it will enhance the therapeutic effects on the tumors. Others in the laboratory had previously ... -
INVESTIGATION OF FUNCTIONAL CONNECTIVITY AND NEUROVASCULAR COUPLING IN DIFFERENT VIGILANCE / BREATH-HOLD STATES OF THE BRAIN FROM SIMULTANEOUS EEG-fNIRS MEASUREMENTS
(2019-07-10)Functional connectivity and neurovascular coupling are important phenomena that occur in the brain. Functional connectivity is the study of functional brain networks and their characteristics. While neurovascular coupling ... -
Investigation Of Neural Correlates Between Perception Of Pain And Hemodynamic Response Measured In The Pre-frontal Cortex Using Functional Near Infra-red Spectroscopy
(Biomedical Engineering, 2011-10-11)Perception of pain is multi-dimensional, comprising three major psychological dimensions: sensory-discriminative, motivational-affective and cognitive-evaluative. This dissertation study investigates the cognitive evaluation ... -
An Investigation Of The Effect Of Obstructive Sleep Apnea On Cerebral Hemodynamics In Relation With Systemic Hemodynamics
Obstructive Sleep Apnea (OSA) is a major sleep disorder affecting approximately 18 million adults in the US. Recent studies have observed cognitive impairments and brain structural changes in OSA subjects where these ... -
Investigations Into Causes Of Failure Of Regenerative Peripheral Nerve Interfaces
All highly selective methods of neural interfacing for mental control of a robotic prosthesis tested to date have exhibited high rates of failure over time. Regenerative peripheral nerve interfaces (RPNIs) may offer the ... -
Kinetics Analyses Of Interactions Between Oncogenic And Tumor Suppressor Proteins By Quantitative High Resolution Microscopy Methods
(Biomedical Engineering, 2013-07-22)DAB2IP is correlated to the risk of aggressive prostate cancer and loss of DAB2IP not only leads to epithelial-to-mesenchymal transition (EMT), but also makes cells radioresistant. These observations support the notion ... -
Localized Treatment of Malignant Melanoma Using a Modified Cellulose-Based Hydrogel Loaded with Temozolomide with Increased Safety of Human Dermal Fibroblasts and the Mechanisms Behind the Effect
(2021-08-30)Melanoma pathophysiology is highly varied, and the initial cause of tumorigenesis is still unknown, but it is likely a combination of both epigenetic and genetic means. Further, melanoma tumors have one of the highest ... -
Long Gap Peripheral Nerve Reconstruction Using Decellularized Nerve Grafts
Peripheral nerve injuries that arise as a result of trauma, tumor excision or birth can adversely affect the quality of patient life, leading to lifelong disabilities in some cases. Autologous nerve grafts are the clinical ... -
LUNG CANCER TARGETED CHEMOTHERAPY VIA HERCEPTIN BASED CHIMERIC ANTIGEN RECEPTOR (CAR) ENGINEERED T CELL MEMBRANE COATED SYNTHETIC NANOPARTICLES
(2019-08-21)Cell membrane-derived nanoparticles recently caught attention due to their desirable features in drug delivery such as mimicking properties of native tissue and cells, avoiding systemic clearance, and alleviating foreign ... -
Machine Learning and Deep Learning Applications in Neuroimaging
(2020-08-20)Deep Learning (DL) tools have the potential to analyze large datasets and extract meaningful insights to enhance patient outcomes. Radiological images such as MRI and CT, often contain complex patterns that can be difficult ... -
Magnetic Drug Targeting: Development Of A Novel Drug Delivery System For Prostate Cancer Therapy
(Biomedical Engineering, 2008-09-17)Magnetic nanoparticles (MNPs) have been attracting a great amount of attention because of their numerous applications including contrast agents in magnetic resonance imaging (MRI), magnetic targeted drug carriers, and ... -
Magnetic-based Theranostic Nanoparticles For Prostate Cancer Management
(Biomedical Engineering, 2013-03-20)With an increasing rate of cancers, the need for effective cancer management has led to the development of theranostic systems for diagnosis and therapy. Conventional techniques for cancer management have limited success ... -
Mapping of Electroencephalogram (EEG) Responses to Newsvendor Decision Model and Cerebral Hemodynamic Responses to Transcranial Photobiomodulation (tPBM) in Humans
(2022-05-17)Decision-making is one of the most critical activities of human beings. Various studies have investigated the brain responses to a variety of decision tasks by deploying the EEG data. The first aim of my dissertation was ... -
MAPPING OF PREFRONTAL HEMODYNAMIC RESPONSES TO NOXIOUS STIMULATION AND CHRONIC PAIN RELATED RESTING-STATE FUNCTIONAL NETWORKS ASSESSED BY fNIRS
(2018-06-01)Neural representations of chronic pain are complex and are least understood. Numerous magnetic resonance imaging (MRI) studies have revealed structural and functional abnormalities in several cortical and sub-cortical ... -
MATHEMATICAL MODELING OF BLOOD PRESSURE AND CEREBRAL BLOOD FLOW USING PHOTOPLETHYSMOGRAPHY SIGNAL
(2019-05-22)Continuous and non-invasive monitoring of blood pressure (BP) and cerebral blood flow (CBF) has numerous clinical and health maintenance applications. Of particular interest is monitoring of BP and CBF during events that ... -
Mechanisms Of Biomaterial Mediated Fibrotic Responses And Strategies To Improve Tissue Reactions To Biomaterial Implants
(Biomedical Engineering, 2010-07-19)Despite considerable advancements in biomaterial synthesis and modification techniques, most tissue engineering scaffolds elicit fibrotic reactions resulting in implant encapsulation, secluding cells and/or therapeutic ...