Browsing PhD Dissertations - DO NOT EDIT by Title
Now showing items 50-69 of 113
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Localized Treatment of Malignant Melanoma Using a Modified Cellulose-Based Hydrogel Loaded with Temozolomide with Increased Safety of Human Dermal Fibroblasts and the Mechanisms Behind the Effect
(2021-08-30)Melanoma pathophysiology is highly varied, and the initial cause of tumorigenesis is still unknown, but it is likely a combination of both epigenetic and genetic means. Further, melanoma tumors have one of the highest ... -
Long Gap Peripheral Nerve Reconstruction Using Decellularized Nerve Grafts
Peripheral nerve injuries that arise as a result of trauma, tumor excision or birth can adversely affect the quality of patient life, leading to lifelong disabilities in some cases. Autologous nerve grafts are the clinical ... -
LUNG CANCER TARGETED CHEMOTHERAPY VIA HERCEPTIN BASED CHIMERIC ANTIGEN RECEPTOR (CAR) ENGINEERED T CELL MEMBRANE COATED SYNTHETIC NANOPARTICLES
(2019-08-21)Cell membrane-derived nanoparticles recently caught attention due to their desirable features in drug delivery such as mimicking properties of native tissue and cells, avoiding systemic clearance, and alleviating foreign ... -
Machine Learning and Deep Learning Applications in Neuroimaging
(2020-08-20)Deep Learning (DL) tools have the potential to analyze large datasets and extract meaningful insights to enhance patient outcomes. Radiological images such as MRI and CT, often contain complex patterns that can be difficult ... -
Magnetic Drug Targeting: Development Of A Novel Drug Delivery System For Prostate Cancer Therapy
(Biomedical Engineering, 2008-09-17)Magnetic nanoparticles (MNPs) have been attracting a great amount of attention because of their numerous applications including contrast agents in magnetic resonance imaging (MRI), magnetic targeted drug carriers, and ... -
Magnetic-based Theranostic Nanoparticles For Prostate Cancer Management
(Biomedical Engineering, 2013-03-20)With an increasing rate of cancers, the need for effective cancer management has led to the development of theranostic systems for diagnosis and therapy. Conventional techniques for cancer management have limited success ... -
Mapping of Electroencephalogram (EEG) Responses to Newsvendor Decision Model and Cerebral Hemodynamic Responses to Transcranial Photobiomodulation (tPBM) in Humans
(2022-05-17)Decision-making is one of the most critical activities of human beings. Various studies have investigated the brain responses to a variety of decision tasks by deploying the EEG data. The first aim of my dissertation was ... -
MAPPING OF PREFRONTAL HEMODYNAMIC RESPONSES TO NOXIOUS STIMULATION AND CHRONIC PAIN RELATED RESTING-STATE FUNCTIONAL NETWORKS ASSESSED BY fNIRS
(2018-06-01)Neural representations of chronic pain are complex and are least understood. Numerous magnetic resonance imaging (MRI) studies have revealed structural and functional abnormalities in several cortical and sub-cortical ... -
MATHEMATICAL MODELING OF BLOOD PRESSURE AND CEREBRAL BLOOD FLOW USING PHOTOPLETHYSMOGRAPHY SIGNAL
(2019-05-22)Continuous and non-invasive monitoring of blood pressure (BP) and cerebral blood flow (CBF) has numerous clinical and health maintenance applications. Of particular interest is monitoring of BP and CBF during events that ... -
Mechanisms Of Biomaterial Mediated Fibrotic Responses And Strategies To Improve Tissue Reactions To Biomaterial Implants
(Biomedical Engineering, 2010-07-19)Despite considerable advancements in biomaterial synthesis and modification techniques, most tissue engineering scaffolds elicit fibrotic reactions resulting in implant encapsulation, secluding cells and/or therapeutic ... -
Metabolic and Electrophysiological Effects of Transcranial Photobiomodulation (PBM) and Multi-wavelength PBM
(2021-05-28)Photobiomodulation (PBM) with near infrared light may become a non-invasive, effective clinical tool after it is understood well for its mechanism of action. In my dissertation research, I have addressed three research ... -
METABOLIC, HEMODYNAMIC AND ELECTROPHYSIOLOGICAL EFFECTS OF TRANSCRANIAL PHOTOBIOMODULATION (tPBM) ON THE HUMAN BRAIN
(2019-08-30)Photobiomodulation (PBM) refers to the use of red-to-near-infrared light to stimulate cellular functions for physiological or clinical benefits. Transcranial photobiomodulation (tPBM) is a noninvasive form of cerebral ... -
Methodological Advances And Application Of Functional Near-infrared Spectroscopy To Guide Cortical Stimulation For Physical Recovery In Patients With Brain Injury
Non-invasive cortical stimulation used in conjunction with physical therapy can enhance the motor performance of persons with brain injury. Transcranial direct current stimulation (tDCS) is a non-invasive cortical stimulation ... -
Methodology Of Citrate-based Biomaterial Development And Application
(Biomedical Engineering, 2012-04-11)Biomaterials play central roles in modern strategies of regenerative medicine and tissue engineering. Attempts to find tissue-engineered solutions to cure various injuries or diseases have led to an enormous increase in ... -
Methodology Of Citric Acid Based Functional Biomaterial Development And Application
(Biomedical Engineering, 2013-03-20)Biomaterials play critical roles in modern strategies of biomedical applications, such as tissue engineering, and theranostic therapy. Attempts to design ideal biomaterials for each specific application have led to an ... -
Micro-device For Selective Isolation And Cytology Of Cancer Cells
(Biomedical Engineering, 2012-07-25)Early detection and isolation of circulating tumor cells (CTCs) can enable early cancer diagnosis and more effective therapeutics. Aptamers have emerged as probe molecules that have binding affinities comparable to antibodies ... -
Microchannel technology in cancer cell confined-migration study and its application in drug screening
(2020-08-10)PDMS-based microchannel device has been explored to extend the basic platform for three-dimensional (3D) culture models of cell motility study because of its relevant stiffness and designable shape. Moreover, it is easy ... -
MODULATION OF PHYSIOLOGIC RESPONSES OF INSULIN SECRETING CELLS USING ELECTRICAL AND PHOTOSTIMULATION
(2020-09-01)Islet transplantation is a surgical procedure aimed at providing insulin independence to those suffering with Type I diabetes. Prior to implantation, a therapeutic window exists ex vivo where the cells can be treated in ... -
MRI Assessment Of Brain Vascular Reactivity To Physiological Challenges
(Biomedical Engineering, 2014-09-17)With a growing need for specific biomarkers in vascular diseases, the past decade has seen a surging interest in mapping brain vascular reactivity. There is great potential that this CVR mapping can be added to standard ... -
Multi-ligand Nanoparticles For Targeted Drug Delivery To The Injured Vascular Wall
(Biomedical Engineering, 2010-11-01)Pathological conditions like coronary artery disease, acute myocardial infarction, stroke, and peripheral artery diseases as well as cardiovascular interventions used in the treatment of coronary artery diseases such as ...