Browsing PhD Dissertations - DO NOT EDIT by Title
Now showing items 71-90 of 113
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NANOPARTICLE-BASED APPROACHES IN CARDIOVASCULAR DISEASES
(2020-08-14)Percutaneous coronary intervention (PCI) such as balloon angioplasty and stent placement are commonly employed for myocardial revascularization. These strategies, however, injure the arterial wall initiating a cascade of ... -
Nanoparticle-Mediated Controlled Myocardial Drug Delivery: A New Treatment for Hypertrophic Cardiomyopathy
(2020-09-04)Hypertrophic cardiomyopathy (HCM) is a genetic disease of the sarcomere, resulting in overgrowth of the septum that separates the left and right ventricles. HCM can affect as many as 1/200 people, making it the most common ... -
NANOPARTICLES FOR GENE THERAPY AND PROTEIN DELIVERY TO INDUCE ANGIOGENESIS AS AN ALTERNATIVE TREATMENT FOR PERIPHERAL ARTERIAL DISEASE
(2018-08-21)Peripheral arterial disease (PAD) is defined as a slow, progressive disorder of the lower extremity arterial vessels characterized by chronic narrowing that often results in occlusion and is associated with loss of functional ... -
NANOSTURCTURED BIOMATERIALS FOR TISSUE REGENERATION AND REPAIR
(2016-09-16)Nanostructured materials have been explored in biomedical field especially in tissue engineering over a past decade. This type of material can be processed into biomaterial scaffolds; revealed many advantages to be used ... -
NATURALLY-DERIVED EXTRACELLULAR MATRIX MATERIALS FOR MENISCUS REPAIR AND REGENERATION
Human meniscus plays critical roles in a knee joint by transmitting weight-bearing force, absorbing shock, and stabilizing the knee joint capsule. Meniscal injuries are mainly caused by sports-related activities and ... -
Non-invasive Biomedical Imaging And Radiobiology Investigations In Pre-clinical Prostate Tumor Models
Oxygen deficiency (hypoxia) in prostate tumors can hinder the biological effectiveness of radiotherapy. Therefore the ability to assess tumor hypoxia non-invasively in vivo in man could significantly improve therapy outcome. ... -
NON-INVASIVE PROFILING OF MOLECULAR MARKERS IN BRAIN GLIOMAS USING DEEP LEARNING AND MAGNETIC RESONANCE IMAGES
(2021-04-29)Gliomas account for the most common malignant primary brain tumors in both pediatric and adult populations. They arise from glial cells and are divided into low grade and high-grade gliomas with significant differences in ... -
Novel analysis of wavelet coherence and phase-amplitude coupling to investigate the human brain at four vigilance states
(2019-08-21)Despite breakthroughs in the field of neuroimaging, there remain many unanswered questions about brain functions and activities and their underlying physiological processes. In my dissertation research, I examined brain ... -
Novel Animal Model And In Vivo Imaging System To Study Inflammatory Response-mediated Cancer Metastasis
(Biomedical Engineering, 2010-07-19)Cancer metastasis is the leading cause of death in cancer patients. A vast majority of cancer-related mortality is attributed to this rather than the primary tumor itself, making the understanding of cancer metastasis ... -
Novel Applications Of Compressed Sensing To Magnetic Resonance Imaging And Spectroscopy
(Biomedical Engineering, 2012-04-11)In this work, three novel applications of compressed sensing to MRI have been developed and implemented which accomplish reduction in acquisition time, thereby also enabling increased spatial and/or temporal resolution. ... -
Novel Intraocular Drug Delivery System For The Prevention Of Posterior Capsule Opacification
(Biomedical Engineering, 2007-08-23)Posterior capsule opacification (PCO) is a major complication associated with the implantation of intraocular lens (IOLs). Evidence suggests that PCO formation is caused by abnormal lens epithelial cell (LEC) migration/p ... -
A Novel Minimally Invasive Dual-modality Fiber Optic Probe For Prostate Cancer Detection
(Biomedical Engineering, 2013-03-20)Prostate cancer is the most common form of cancer in males, and is the second leading cause of cancer related deaths in United States. In prostate cancer diagnostics and theapy, there is a critical need for a minimally ... -
NOVEL NANOCOMPOSITES FOR THE TREATMENT OF LUNG INFECTIONS
(2022-05-17)Lung infections, especially lower respiratory tract infections and their associated pneumonias, are one of the leading causes of death, accounting for more than 4 million fatalities every year worldwide. Bacterial pathogens ... -
NOVEL NANOPARTICLES TO STIMULATE THERAPEUTIC ANGIOGENESIS FOR THE TREATMENT OF PERIPHERAL ARTERIAL DISEASES
(2022-08-15)Peripheral arterial disease (PAD) is a severe impairment of arterial vessels resulting in obstruction of normal blood flow in the legs, leading to acute or chronic lower limb ischemia and subsequently high morbidity and ... -
Novel Quantification of Neurovascular Coupling (NVC) to Predict Brain Injury in Neonates with Hypoxic Ischemic Encephalopathy
(2020-09-04)Birth asphyxia is a global burden in clinical neonatal care. It results from deprivation of oxygen to a newborn infant that lasts too long during the birth causing physical harm to the brain. The asphyxia insult impairs ... -
Novel ¹H MR Probes To Interrogate The Tumor Microenvironment
(Biomedical Engineering, 2011-10-11)The term "tumor microenvironment" usually refers to the description of the physiological and metabolic conditions within solid tumors (primary or metastatic), and is significantly different from that of normal tissues. ... -
Peripheral Nerve Injuries: Pleiotrophin-mediated Regeneration Across Long-gap Injuries And Investigations Into Amputation Neuroma Pain
Peripheral nerve injuries can be a chronic clinical challenge for patients. Long recovery periods, functional deficits, and neuropathic pain all complicate healing. Although peripheral nerves are able to regenerate, most ... -
Phase Sensitive Spectral Domain Interferometry For Label Free Biomolecular Interaction Analysis And Biosensing Applications
(Biomedical Engineering, 2013-03-20)Biomolecular interaction analysis (BIA) plays vital role in wide variety of fields, which include biomedical research, pharmaceutical industry, medical diagnostics, and biotechnology industry. Study and quantification of ... -
PHOTOBIOMODULATION AND STEM CELL DIFFERENTIATION: APPLICATION TO MODULATE ADIPOGENESIS THROUGH CELLULAR AND NUCLEAR MORPHOLOGY
(2020-05-28)Mesenchymal stem cells (MSCs) are of great interest in regenerative medicine due to their capability to self-renew and differentiate to various lineages. Typically, differentiation to specific cell types has relied on ... -
PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION COATING AMORPHOUS SILICA BASED IMPLANTS ENHANCING ANGIOGENESIS AND MITIGATING TOXIC OXIDATIVE STRESS IN CRITICAL SIZE BONE DEFECTS
(2017-12-18)The advances in bone tissue engineering search for a biomaterial that could efficiently and gradually replace the bone while the new tissue grows through the implanted structure. However, due to limitations mainly related ...