Browsing PhD Dissertations - DO NOT EDIT by Title
Now showing items 87-106 of 113
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Peripheral Nerve Injuries: Pleiotrophin-mediated Regeneration Across Long-gap Injuries And Investigations Into Amputation Neuroma Pain
Peripheral nerve injuries can be a chronic clinical challenge for patients. Long recovery periods, functional deficits, and neuropathic pain all complicate healing. Although peripheral nerves are able to regenerate, most ... -
Phase Sensitive Spectral Domain Interferometry For Label Free Biomolecular Interaction Analysis And Biosensing Applications
(Biomedical Engineering, 2013-03-20)Biomolecular interaction analysis (BIA) plays vital role in wide variety of fields, which include biomedical research, pharmaceutical industry, medical diagnostics, and biotechnology industry. Study and quantification of ... -
PHOTOBIOMODULATION AND STEM CELL DIFFERENTIATION: APPLICATION TO MODULATE ADIPOGENESIS THROUGH CELLULAR AND NUCLEAR MORPHOLOGY
(2020-05-28)Mesenchymal stem cells (MSCs) are of great interest in regenerative medicine due to their capability to self-renew and differentiate to various lineages. Typically, differentiation to specific cell types has relied on ... -
PLASMA ENHANCED CHEMICAL VAPOR DEPOSITION COATING AMORPHOUS SILICA BASED IMPLANTS ENHANCING ANGIOGENESIS AND MITIGATING TOXIC OXIDATIVE STRESS IN CRITICAL SIZE BONE DEFECTS
(2017-12-18)The advances in bone tissue engineering search for a biomaterial that could efficiently and gradually replace the bone while the new tissue grows through the implanted structure. However, due to limitations mainly related ... -
Pleiotrophin Enhance Nerve Regeneration Across Long Gap Peripheral Nerve Defects
Peripheral nerve injuries resulting in extensive loss in nerve continuity pose a challenge in reconstructive surgery. Autografts still remain the treatment of choice for nerve defects despite the need of donor nerve harvest ... -
Poly(lactic-co-glycolic acid) Nanoparticle Delivery of Notch Intracellular Domain Plasmid to Restore Notch Signaling
(2021-08-23)Notch signaling is a highly conserved signaling system that is required for embryonic development and regeneration of organs. When the signal is lost, maldevelopment occurs and leads to a lethal state. Delivering exogenous ... -
Polymeric Nano/ Microparticles For Management Of Pulmonary Diseases
Drug delivery via pulmonary route has emerged as an attractive area of study in the past two decades. This method of administration has multiple advantages for both systemic and local drug delivery due to the availability ... -
PORCINE NEONATAL HEART EXTRACELLULAR MATRIX AS A REGENERATION PLATFORM
(2021-08-16)Each year, an estimated 620,000 Americans have new heart attack and suffer from myocardial infarction (MI) that results in massive heart cell death and decrease in heart function. Various therapeutic strategies, such as ... -
Protoporphyrin IX (PpIX)-conjugated Self-lighting Nanoparticles For Photodynamic Therapy: Synthesis And Characterization
In Photodynamic therapy (PDT) PDT, cancer destruction relies on applying a photosensitizing drug (PS) followed by light. Absorbed light can activate the PS to transfer energy to existing molecules and substrates or to ... -
Quantification and identification of neuro-electrophysiological markers and brain network for biomedical applications
(2023-08-23)Electroencephalogram (EEG) can detect and monitor neuro-electrophysiological signals in the human brain, including assessing brain function in newborns at risk of neurological injury and healthy adults undergoing intervention ... -
RATIONAL DESIGN AND SYNTHESIS OF BIODEGRADABLE POLYURETHANE BASED BIOMATERIALS
(2018-12-04)Biodegradable polyurethanes have been applied in biomedical field since 1960s. In recent years, biodegradable polyurethanes have been widely investigated for tissue repair and regeneration because of their good mechanical ... -
Resolution And Localization In Single Molecule Microscopy
(Biomedical Engineering, 2007-09-19)Rayleigh's criterion is extensively used in optical microscopy to determine the resolution of microscopes. Despite its widespread use, it is well known that this criterion is based on heuristic notions and can be surpassed ... -
REVEALING HEMODYNAMIC RESPONSE AND DYNAMIC CHANGES IN FUNCTIONAL CORTICAL NETWORKS USING FUNCTIONAL NEAR-INFRARED SPECTROSCOPY (fNIRS)
(2017-12-15)Therapeutic interventions, such as physical therapy and non-invasive brain electrical stimulation can enhance the physical performance of persons with brain disorders. One often-used form of physical therapy named ... -
Stimuli-responsive nanoparticles for treatment of lung cancer
(2018-12-06)Despite extensive research and progress in anti-cancer therapeutics, an effective treatment for non-small cell lung cancer (NSCLC) remains elusive, resulting in poor 5-year patient survival rate. Towards this end, we have ... -
Targeted Delivery Of Carbon Nanotubes To Cancer Cells
(Biomedical Engineering, 2010-07-19)CD22 is broadly expressed on human B cell lymphomas. Monoclonal anti-CD22 antibodies (MAbs) alone, or coupled to toxins, have been used to selectively target these tumors both in severe combined immunodeficient (SCID) mice ... -
TARGETED DRUG-LOADED NANOPARTICLE SYSTEM (TDNPS) TO AMELIORATE AND TREAT IDIOPATHIC LUNG FIBROSIS
(2022-12-19)Idiopathic pulmonary fibrosis (IPF) is a fatal progressive disease with a dismal prognosis and 3-5 years of survival. Up to date, there are no effective treatments, and a few current therapies that do not ameliorate the ... -
Targeting the Oligomannose Biomarker Present on Distinct Subsets of Non-Hodgkin Lymphomas
(2020-09-04)Subtypes of B cell non-Hodgkin’s lymphomas, including follicular lymphomas, have shown a unique high oligomannose presentation on their immunoglobulins that will interact with natural receptors of the innate immunity, ... -
TECHNIQUES TO IMPROVE ULTRASOUND-SWITCHABLE FLUORESCENCE IMAGING
(2017-08-14)Novel approaches to the improvement of ultrasound-switchable fluorescence (USF) imaging—a relatively new imaging modality that combines ultrasound and optical imaging techniques—have been proposed for early cancer detection. ... -
The Biomechanics of Cardiac Elastin and its Role in Bioengineering
(2020-09-09)Elastin is an essential structural protein responsible for the elasticity of many tissues, including skin, lungs, blood vessels, and other highly dynamic tissues and organs in the body. In the heart, cardiac elastin has ... -
The Hip-Spine Effect: How Pathological Femoro-Pelvic Interactions Contribute to Abnormal Lumbar Spine Loading
(2019-05-06)ABSTRACT THE HIP-SPINE EFFECT: HOW PATHOLOGICAL FEMORO-PELVIC INTERACTIONS CONTRIBUTE TO ABNORMAL LUMBAR SPINE LOADING Anthony Nicholas Khoury, Ph.D. The University of Texas at Arlington, 2019 Supervising Professor: Hal ...