PhD Dissertations - DO NOT EDIT: Recent submissions
Now showing items 21-40 of 113
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LUNG CANCER TARGETED CHEMOTHERAPY VIA HERCEPTIN BASED CHIMERIC ANTIGEN RECEPTOR (CAR) ENGINEERED T CELL MEMBRANE COATED SYNTHETIC NANOPARTICLES
(2019-08-21)Cell membrane-derived nanoparticles recently caught attention due to their desirable features in drug delivery such as mimicking properties of native tissue and cells, avoiding systemic clearance, and alleviating foreign ... -
DEVELOPMENT AND INVESTIGATION OF FLUORESCENCE IMAGING PROBES
(2019-09-03)Fluorescence imaging has attracted much attention due to high sensitivity, spatial and temporal resolution, and fast acquisition time, for imaging biomolecular processes and for diagnosis of diseases such as cancer in early ... -
Novel analysis of wavelet coherence and phase-amplitude coupling to investigate the human brain at four vigilance states
(2019-08-21)Despite breakthroughs in the field of neuroimaging, there remain many unanswered questions about brain functions and activities and their underlying physiological processes. In my dissertation research, I examined brain ... -
ULTRASOUND SWITCHABLE FLUORESCENCE IMAGING BASED ON A TIME GATED ICCD CAMERA
(2019-08-08)Ultrasound switchable fluorescence (USF) imaging has been proposed as a novel imaging modality which provides microscopic fluorescence imaging in centimeter-deep tissue. USF is possible to reveal many interesting phenomena ... -
Development of medical devices for diagnosing cartilage injury and metastatic cancers
(2019-08-07)My research focused on applying biomedical engineering techniques to diagnose different diseases and conditions. The results of these work led to one published paper and two submitted manuscripts which are summarized in ... -
APPLICATION OF TISSUE ENGINEERING TECHNIQUES FOR TREATING CARTILAGE INJURY AND DIAGNOSING CANCER METASTASIS
(2019-08-05)This study focuses on the application of tissue engineering techniques for the diagnosis of cancer metastasis, cartilage regeneration, and modeling of lymph node metastasis. Chapter 1 is an overview of tissue engineering ... -
DESIGN, DEVELOPMENT, AND VALIDATION OF A NOVEL OPTICAL IMAGING DEVICE FOR BIOMEDICAL APPLICATIONS
(2019-07-31)Fluorescence and luminescence imaging are two promising optical techniques for diagnosing a variety of critical pathologies in vivo, including wound healing, inflammation, and vascular diseases. Despite this, there is a ... -
Targeting the Oligomannose Biomarker Present on Distinct Subsets of Non-Hodgkin Lymphomas
(2020-09-04)Subtypes of B cell non-Hodgkin’s lymphomas, including follicular lymphomas, have shown a unique high oligomannose presentation on their immunoglobulins that will interact with natural receptors of the innate immunity, ... -
Microchannel technology in cancer cell confined-migration study and its application in drug screening
(2020-08-10)PDMS-based microchannel device has been explored to extend the basic platform for three-dimensional (3D) culture models of cell motility study because of its relevant stiffness and designable shape. Moreover, it is easy ... -
EVALUATION OF A PERSONAL MOBILE TRAINER SYSTEM DESIGNED FOR FACILITATING EXERCISE THERAPY FOR TRAUMATIC BRAIN INJURY PATIENTS
(2021-08-16)There are no effective pharmacological agents that can prevent or treat post-TBI cognitive deterioration. Previous research has shown that exercise can be an effective means of enhancing the patients condition with mild ... -
Localized Treatment of Malignant Melanoma Using a Modified Cellulose-Based Hydrogel Loaded with Temozolomide with Increased Safety of Human Dermal Fibroblasts and the Mechanisms Behind the Effect
(2021-08-30)Melanoma pathophysiology is highly varied, and the initial cause of tumorigenesis is still unknown, but it is likely a combination of both epigenetic and genetic means. Further, melanoma tumors have one of the highest ... -
Poly(lactic-co-glycolic acid) Nanoparticle Delivery of Notch Intracellular Domain Plasmid to Restore Notch Signaling
(2021-08-23)Notch signaling is a highly conserved signaling system that is required for embryonic development and regeneration of organs. When the signal is lost, maldevelopment occurs and leads to a lethal state. Delivering exogenous ... -
PHOTOBIOMODULATION AND STEM CELL DIFFERENTIATION: APPLICATION TO MODULATE ADIPOGENESIS THROUGH CELLULAR AND NUCLEAR MORPHOLOGY
(2020-05-28)Mesenchymal stem cells (MSCs) are of great interest in regenerative medicine due to their capability to self-renew and differentiate to various lineages. Typically, differentiation to specific cell types has relied on ... -
Metabolic and Electrophysiological Effects of Transcranial Photobiomodulation (PBM) and Multi-wavelength PBM
(2021-05-28)Photobiomodulation (PBM) with near infrared light may become a non-invasive, effective clinical tool after it is understood well for its mechanism of action. In my dissertation research, I have addressed three research ... -
AN IN VITRO MODEL TO STUDY THE ROLE OF IOL: LENS CAPSULE INTERACTIONS IN POSTERIOR CAPSULE OPACIFICATION
(2021-05-05)Posterior capsule opacification (PCO) is the most common complication associated with intraocular lens (IOL) implantation. Unfortunately, current in vitro models cannot be used to assess the potential of PCO due to their ... -
NON-INVASIVE PROFILING OF MOLECULAR MARKERS IN BRAIN GLIOMAS USING DEEP LEARNING AND MAGNETIC RESONANCE IMAGES
(2021-04-29)Gliomas account for the most common malignant primary brain tumors in both pediatric and adult populations. They arise from glial cells and are divided into low grade and high-grade gliomas with significant differences in ... -
Development of Particle Platforms for Delivery of Angiogenic Reagents to Treat Peripheral Arterial Diseases
(2019-01-11)Peripheral arterial disease (PAD) is a disease that one or several peripheral arteries are narrowed or blocked. PAD is an emerging disease that cost annually 10-20 billions of US dollars for health care in America. PAD ... -
Stimuli-responsive nanoparticles for treatment of lung cancer
(2018-12-06)Despite extensive research and progress in anti-cancer therapeutics, an effective treatment for non-small cell lung cancer (NSCLC) remains elusive, resulting in poor 5-year patient survival rate. Towards this end, we have ... -
Whole-head functional brain imaging of economic risk decision making and transcranial photobiomodulation with fNIRS and EEG
(2020-09-08)Functional near-infrared spectroscopy (fNIRS) and electroencephalography (EEG) are two non-invasive brain imaging or mapping modalities that allow us to measure cerebral hemodynamic and electrophysiological changes in the ... -
IMPACT OF MUSCULAR FATIGUE AND ITS MODULATION USING TRANSCRANIAL PHOTOBIOMODULATION (tPBM) ON THE HUMAN BRAIN MEASURED BY FUNCTIONAL NEAR-INFRARED SPECTROSCOPY (fNIRS)
(2020-07-22)When performing exercise, the brain must register and simultaneously integrate input from feedforward (i.e., central command) and feedback (e.g., exercise pressor reflex) neural mechanisms to make appropriate cardiovascular ...