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Increasing Lipophilicity Of Redox Active Ruthenium Complexes As A Means To Enhance Cytotoxicity And Reduce Animal Toxicity
(Chemistry & Biochemistry, 2013-03-20)
The dinuclear and monomeric ruthenium(II) polypyridyl complexes [(phen)2Ru(tatpp)Ru(phen)2]Cl4 (P) and monomer [(phen)2Ru(tatpp)]Cl2 (MP) are promising candidates for anticancer drug development in terms of the observed ...
Proteomic Strategies For Investigation Of Protein/ligand And Peptide/ligand Non-covalent Interactions By Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2008-08-08)
Through universal proteomic methods and electrospray ionization-mass spectrometry (ESI-MS), multiple molecular recognition strategies were investigated as a prospective complementary tool for investigating protein-ligand ...
Chiral Recognition And Binding Constant Determination In Monovalent And Bivalent Systems Using Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2008-09-17)
Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization method which is capable of transferring weakly bound host-guest noncovalent complexes from the solution phase to the gas phase. This capability makes ...
Ionization Competitors Extend The Linear Range Of Electrospray Ionization Mass Spectrometry
(Chemistry & Biochemistry, 2010-03-03)
ESI-MS has proven its applicability in quantitative analysis for a wide range of analytes. Its effectiveness relies on achieving sensitivity and linear range, although the latter is known to be limited. ESI-MS response ...
Analytical Characterization Of Anthocyanins From Natural Products By Reverse-phase Liquid Chromatography-photodiode Array-electrospray Ionization-ion Trap-time Of Flight Mass Spectrometry
(Chemistry & Biochemistry, 2011-03-03)
Anthocyanins are known to be one of the most powerful phytochemical antioxidant and believed to have a positive influence on a variety of health conditions. Numerous studies continue on these compounds that are readily ...
Method development for qualification and quantification of cannabinoids and terpenes in extracts by Gas chromatography-mass spectrometry
(2016-07-19)
Cannabinoids are a class of chemical compounds that act on cannabinoid receptors in cells. These receptors have different kinds of ligands, including endocannabinoids (produced in the body by humans and animals), ...
ANTIBACTERIAL DRUG DESIGN AND DISCOVERY VIA VITAMIN B1 BIOSYNTHETIC PATHWAY
(2016-08-15)
Antibiotics play a vital role in fighting infectious disease caused by bacterial species. Antimicrobial resistance has been shown for every current antibiotic and poses a major health risk. To combat these growing threats ...
The Role of HOTAIR in Skeletal Muscle Myogenesis
(2016-07-19)
Skeletal muscle function is a vital requirement for an enriched healthy life. For years the molecular processes governing myogenesis and the development of skeletal muscle were primarily associated with proteins. In recent ...
DERIVATIZATION OF SMALL ACIDS TO ENHANCE SENSITIVITY IN GAS CHROMATOGRAPHY MASS SPECTROMETRY AND GAS CHROMATOGRAPHY VACUUM ULTRAVIOLET SPECTROSCOPY
(2016-08-12)
Disinfection by-products (DBPs) are a significant concern in drinking water quality. Haloacetic acids, which are generated from disinfection processes, are one of the major groups in disinfection by-products. Because they ...
INCREASED HYDRIDE TRANSFER RATES WITHIN T09A MUTANT OF F420:H2 NADP+ OXIDOREDUCTASE
(2016-05-18)
F420:H2 NADP+ oxidoreductase (Fno) is an F420 dependent enzyme found in methanogens and sulfate reducing archaea. Fno catalyzes the reversible reduction of NADP+ to NADPH through the transfer of a hydride involving F420 ...